A5065597522- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
- Cellular Mechanics and Interactions
- Protein purification and stability
- Cell Adhesion Molecules Research
- Viral Infectious Diseases and Gene Expression in Insects
- HER2/EGFR in Cancer Research
- Genetics and Neurodevelopmental Disorders
- Cellular transport and secretion
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- Peptidase Inhibition and Analysis
McGill University
2023
Montreal Neurological Institute and Hospital
2022-2023
Genomics (United Kingdom)
2023
Weatherford College
2022
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of problem remains largely anecdotal, as such, feasibility goal at least one potent specific antibody targeting each protein in a proteome cannot be assessed. Focusing for human proteins, we have scaled standardized characterization approach using parental knockout cell lines (Laflamme et al.,...
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of problem remains largely anecdotal, as such, feasibility goal at least one potent specific antibody targeting each protein in a proteome cannot be assessed. Focusing for human proteins, we have scaled standardized characterization approach using parental knockout cell lines (Laflamme et al.,...
<ns4:p>Ubiquilin-2, a member of the ubiquilin protein family, plays role in regulation various degradation pathways, and is mutated some neurodegenerative diseases. Well-characterized anti-Ubiquilin-2 antibodies would advance reproducible research for Ubiquilin-2 turn, benefit scientific community. In this study, we characterized ten commercial Western Blot, immunoprecipitation, immunofluorescence using standardized experimental protocol based on comparing read-outs knockout cell lines...
Profilin-1, a member of the Profilin family, is ubiquitously expressed protein that controls actin polymerization in concentration-dependent manner. As mutations Profilin-1 gene have potential implications neurodegenerative disease progression, well-characterized anti-Profilin-1 antibodies would be beneficial to scientific community. In this study, we characterized sixteen commercial for Western blot, immunoprecipitation, and immunofluorescence applications, using standardized experimental...
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of problem remains largely anecdotal, as such, feasibility goal at least one potent specific antibody targeting each protein in a proteome cannot be assessed. Focusing for human proteins, we have scaled standardized characterization approach using parental knockout cell lines (Laflamme et al.,...
Antibodies are critical reagents to detect and characterize proteins. It is commonly understood that many commercial antibodies do not recognize their intended targets, but information on the scope of problem remains largely anecdotal, as such, feasibility goal at least one potent specific antibody targeting each protein in a proteome cannot be assessed. Focusing for human proteins, we have scaled standardized characterization approach using parental knockout cell lines (Laflamme et al.,...