A5014978180- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Inflammation biomarkers and pathways
- Hematopoietic Stem Cell Transplantation
- Genetics and Neurodevelopmental Disorders
- Innovations in Medical Education
- Suicide and Self-Harm Studies
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Infectious Encephalopathies and Encephalitis
- Primary Care and Health Outcomes
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury Research
- Iron Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Herpesvirus Infections and Treatments
Mayo Clinic in Florida
2021-2025
Nemours Children's Health System
2023-2024
Jacksonville College
2021-2023
University of Pennsylvania
2022-2023
Children's Hospital of Philadelphia
2022-2023
Nemours Children's Clinic
2021-2022
Indiana University – Purdue University Indianapolis
2016
Riley Hospital for Children
2016
Indiana University Health
2016
University of Florida Health
2014
<h3>Objectives</h3> Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated neuroinflammatory disorder leading to demyelination of the CNS. Interleukin (IL)-6 receptor blockade under study in relapsing MOGAD as a preventative strategy, but little known about role such treatment for acute attacks. <h3>Methods</h3> We discuss cases 7-year-old boy and 15-year-old adolescent with severe CNS malignant cerebral edema early brain herniation associated clearly...
Encephalopathy is a disturbance in neurologic function. It commonly attributed to infectious and inflammatory etiologies but encompasses wide differential. Hypereosinophilic syndrome (HES) rare cause of encephalopathy that associated with underlying infection or malignancy. We present pediatric patient who experienced several days worsening neurological deterioration influenza B hypereosinophilia. A thorough workup ultimately revealed diagnosis HES secondary cell acute lymphoblastic leukemia...
Neurologic manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients have been reported the and postinfectious stages disease 2019. Acute disseminated encephalomyelitis (ADEM) typically presents children after a viral illness at mean age 3 to 7 years. A total 60% 90% literature-reported with ADEM minimal no neurologic deficits long-term follow-up. We present 17-month-old developmentally typical girl parental complaints irritability, upper...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory of the central nervous system caused by autoantibodies against aquaporin-4 (AQP4) water channel. Inflammatory injury often severe and focused on optic nerves, spinal cord, other CNS regions with high AQP4 expression. Acute management includes pulse corticosteroids plasmapheresis; however, many patients have incomplete recovery. We describe successful use eculizumab in treating acute refractory brainstem syndrome a...
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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory disorder of the CNS with a variety clinical manifestations, including cerebral edema.A 7-year-old boy presented headaches, nausea, and somnolence. He was found to have edema that progressed brainstem herniation. Invasive multimodality neuromonitoring initiated guide management intracranial hypertension hypoxia while he received empiric therapies for neuroinflammation. Workup revealed serum myelin...
To describe a case of acute demyelinating encephalomyelitis (ADEM) in infancy following SARS-CoV-2 infection.
: We present a patient with anti-N-methyl D-aspartate receptor (NMDAR) encephalitis who presented focal motor seizures that rapidly progressed to epilepsia partialis continua (EPC) unilateral background slowing then encephalopathy. A 12-year-old previously healthy girl our pediatric emergency department two weeks of new onset impaired awareness but no interictal changes in mental status, behavior, or movement. EEG initially demonstrated left central and temporal spike wave discharges...
Introduction: The National Institutes of Health Stroke Scale (NIHSS) quantifies physical impairment caused by stroke. Emergency Medicine (EM) physicians must be competent to perform the NIHSS as scale cut points are utilized identify patients with acute ischemic stroke who may candidates for thrombolytic therapy. Simulation is a teaching method that integrates imitation real life scenarios into educational exercises. This study discerned if standardized patient simulation can adopted an...
Familiarize neurologists with the association between herpes simplex encephalitis (HSE) and N-Methyl-D-aspartic acid receptor (NMDARE). Case report literature review We describe case of a six-year-old boy who experienced neonatal virus (HSV) infection, effective early antiviral therapy, then HSE followed by relapsing NMDARE at 2 years age. Diagnostic therapeutic considerations for HSV, HSE, are presented, emphasis on role immunosuppression in even children prior HSE. The prognosis importance...