A5072643963- Scientific Computing and Data Management
- Distributed and Parallel Computing Systems
- Research Data Management Practices
- Parallel Computing and Optimization Techniques
- Cerebrovascular and Carotid Artery Diseases
- Embedded Systems Design Techniques
- Head and Neck Surgical Oncology
- Advanced Memory and Neural Computing
- Microbial Metabolic Engineering and Bioproduction
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Formal Methods in Verification
- Ferroelectric and Negative Capacitance Devices
- Sarcoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Low-power high-performance VLSI design
- Model-Driven Software Engineering Techniques
- VLSI and FPGA Design Techniques
- Enzyme Catalysis and Immobilization
- Genetics, Bioinformatics, and Biomedical Research
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
Nuffield Orthopaedic Centre
2025
University of Manchester
2004-2023
University of Connecticut
2008-2019
Memorial Medical Center
2018
UMass Memorial Health Care
2018
Engineering and Physical Sciences Research Council
2016
Biotechnology and Biological Sciences Research Council
2016
UConn Health
2008-2013
Cardiff University
2013
University of Amsterdam
2013
The Taverna workflow tool suite (http://www.taverna.org.uk) is designed to combine distributed Web Services and/or local tools into complex analysis pipelines. These pipelines can be executed on desktop machines or through larger infrastructure (such as supercomputers, Grids cloud environments), using the Server. In bioinformatics, workflows are typically used in areas of high-throughput omics analyses (for example, proteomics transcriptomics), for evidence gathering methods involving text...
The microbial production of fine chemicals provides a promising biosustainable manufacturing solution that has led to the successful growing catalog natural products and high-value chemicals. However, development at industrial levels been hindered by large resource investments required. Here we present an integrated Design-Build-Test-Learn (DBTL) pipeline for discovery optimization biosynthetic pathways, which is designed be compound agnostic automated throughout. We initially applied...
In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such depends on the discipline science humble bricks mortar that make integration possible; identifiers a core component this infrastructure. Drawing our experience work by other groups, we outline 10 lessons have learned about identifier qualities best practices facilitate large-scale integration. Specifically, propose actions...
Subcortical microvascular disease represented by brain white matter hyperintensity on magnetic resonance imaging is associated with functional decline in older people hypertension. The effects of 2 levels 24-hour average systolic blood pressure (BP) mobility, progression, and cognitive function over 3 years were studied.This trial was a prospective, randomized, blinded end-points study patients ≥75 age hypertension evidence lesions. Patients randomized to mean BP ≤130 mm Hg (intensive...
Study Design Nonexperimental, retrospective design. Objectives This study was designed to compare clinical diagnostic accuracy (CDA) between physical therapists (PTs), orthopaedic surgeons (OSs), and nonorthopaedic providers (NOPs) at Keller Army Community Hospital on patients with musculoskeletal injuries (MSI) referred for magnetic resonance imaging (MRI). Background US PTs are frequently the first credentialed privileged examine diagnose injuries. Physical assigned have also been...
This work presents sPyNNaker 4.0.0, the latest version of software package for simulating PyNN-defined spiking neural networks (SNNs) on SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven neuron state updates and pipelined event-driven spike processing. Preprocessing, execution, neuron/synapse model implementations discussed, all in context a simple example SNN. Simulation...
Haller cells are anterior ethmoid air located in the medial orbital floor immediately lateral to maxillary infundibulum. The purpose of this study was demonstrate prevalence and relationship between existence size these with ipsilateral sinusitis dehiscence as visualized on cone beam CT (CBCT) images.CBCT image volumes 50 patients were retrieved analysed. All CBCT images acquired a 9-inch field view scan. χ(2) Cochran-Mantel-Haenszel tests used for statistical analysis obtained data,...
Summary Age‐associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricle surface gliosis associated ventriculomegaly. To examine whether loss ependymal cell coverage resulting in glial scarring can lead enlargement independent any other injury...
Giant cell tumour of bone (GCTB) is viewed as a benign, locally aggressive primary with metastatic potential. Current management surgery curettage or resection and systemic therapy denosumab. Diagnosis confirmed histologically prior to surgery, staging for pulmonary disease, metastases (PM) reportedly occur in <8%. This study aimed assess incidence, surveillance PM patients GCTB, histopathological review. A retrospective audit the Oxford registry was performed from January 2014 - October...
SpiNNaker is a massively parallel distributed architecture primarily focused on real time simula- tion of spiking neural networks. The largest realisation the consists one million general purpose processors, making it neuromorphic computing platform in world at present time. Utilising these processors efficiently requires expert knowledge archi- tecture to generate executable code and harness potential unique inter-processor communications infra-structure that lies heart architecture. This...
Making forecasts about biodiversity and giving support to policy relies increasingly on large collections of data held electronically, substantial computational capability capacity analyse, model, simulate predict using such data. However, the physically distributed nature resources expertise in advanced analytical tools creates many challenges for modern scientist. Across wider biological sciences, presenting capabilities Internet (as “Web services”) scientific workflow systems compose them...
A 34-year-old man with right-sided cluster headache presented a stroke from moyamoya. Following surgery on the right, both moyamoya and remitted, but eighteen months later attack symptoms of cerebral ischemia recurred left. Again, following left, attacks disappeared. Cluster secondary to has not previously been described.
The Manchester Synthetic Biology Research Centre (SYNBIOCHEM) is a foundry for the biosynthesis and sustainable production of fine speciality chemicals. Centre's integrated technology platforms provide unique capability to facilitate predictable engineering microbial bio-factories chemicals production. An overview these capabilities described.
The UK Synthetic Biology Research Centre, SYNBIOCHEM, hosted by the Manchester Institute of Biotechnology at University is delivering innovative technology platforms to facilitate predictable engineering microbial bio-factories for fine and speciality chemicals production. We provide an overview our foundry activities that are being applied grand challenge projects deliver innovation in bio-based production industrial biotechnology.
An osteolytic lesion with a small central area of mineralization and sclerotic borders was discovered incidentally in the clivus on cone-beam computed tomography (CBCT) 27-year-old male patient. This benign appearance indicated primary differential diagnosis non-aggressive lesions such as fibro-osseous arrested pneumatization. Further, magnetic resonance imaging (MRI), showed homogenously low T1 signal intensity mild internal enhancement after post-gadolinium heterogeneous T2 intensity....