A5055252334- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Glycogen Storage Diseases and Myoclonus
- Lysosomal Storage Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and biosynthesis
- Lipoproteins and Cardiovascular Health
- Carbohydrate Chemistry and Synthesis
- Diet and metabolism studies
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Family and Disability Support Research
- Immune cells in cancer
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatitis Pathology and Treatment
University Medical Center Groningen
2018-2025
University of Groningen
2018-2025
Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect of cholesterol efflux pathways mediated ATP-binding cassette A1 and G1 (ABCA1/ABCG1) on cell-dependent age-related inflammation atherosclerosis remains poorly understood. In this study, we generate mice with cell-specific Abca1/Abcg1-deficiency low-density-lipoprotein-receptor deficient (Ldlr-/-) background....
Background and AimsBile acids (BAs) aid intestinal fat absorption exert systemic actions by receptor-mediated signaling. BA receptors have been identified as drug targets for liver diseases. Yet, differences in metabolism between humans mice hamper translation of pre-clinical outcomes. Cyp2c70-ablation prevents synthesis mouse/rat-specific muricholic (MCAs), but potential (patho)physiological consequences their absence are unknown. We therefore assessed age- gender-dependent effects...
BACKGROUND: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α 1 -AR signaling and promotes loss of SMC contractile markers in vitro. ABCA1 ABCG1 (ATP-binding cassette transporter A1 G1) mediate efflux to HDL (high-density lipoprotein). ABCA1/ABCG1 show high expression medial low intimal SMCs atherosclerotic plaques. The role SMC-mediated atherogenesis remains poorly...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): VIDI grant from Netherlands Organization Scientific Research (NWO). Rosalind Franklin Fellowship the University Medical Center Groningen. Both to Marit Westerterp, PhD Smooth muscle cells (SMCs) regulate blood flow distribution and pressure via vasoconstriction mediated by α-adrenergic receptors (α-ARs). Plasma membrane cholesterol may affect α1-AR signaling, but consequences...
Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims prevent hypoglycemia, patients still experience hypoglycemic events. Poor glycemic control associated with hypertriglyceridemia, hepatocellular adenoma and carcinoma, also an increased bleeding tendency of unknown origin. To...
Niemann-Pick type C1 (NPC1) disease is a progressive lysosomal storage disorder caused by mutations of the NPC1 gene. While neurodegeneration most severe symptom, large proportion patients also present with splenomegaly, which has been attributed to cholesterol and glycosphingolipid accumulation in late endosomes lysosomes. However, recent data reveal an increase inflammatory monocyte subset Npc1
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a mouse model that resembles the hyperlipidemia in patients, we here found increased Ia. These data provide rationale for investigating larger patient cohort.
ABSTRACT Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T-cells accumulate cholesterol, which could lead to pro-inflammatory phenotype. However, the role of cholesterol efflux pathways mediated ATP-binding cassette A1 and G1 (ABCA1/ABCG1) in T-cell-dependent age-related inflammation atherosclerosis remains poorly understood. In this study, we generated mice with T-cell-specific Abca1/Abcg1 -deficiency on low-density-lipoprotein-receptor...