A5004717882- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Carbohydrate Chemistry and Synthesis
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Lysosomal Storage Disorders Research
- Advanced Glycation End Products research
- Inflammatory mediators and NSAID effects
- Lipid metabolism and biosynthesis
- Hormonal Regulation and Hypertension
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Glycogen Storage Diseases and Myoclonus
University Medical Center Groningen
2021-2025
University of Groningen
2021-2025
Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect of cholesterol efflux pathways mediated ATP-binding cassette A1 and G1 (ABCA1/ABCG1) on cell-dependent age-related inflammation atherosclerosis remains poorly understood. In this study, we generate mice with cell-specific Abca1/Abcg1-deficiency low-density-lipoprotein-receptor deficient (Ldlr-/-) background....
BACKGROUND: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α 1 -AR signaling and promotes loss of SMC contractile markers in vitro. ABCA1 ABCG1 (ATP-binding cassette transporter A1 G1) mediate efflux to HDL (high-density lipoprotein). ABCA1/ABCG1 show high expression medial low intimal SMCs atherosclerotic plaques. The role SMC-mediated atherogenesis remains poorly...
Background and aimsHigh lipoprotein (a) [Lp(a)] plasma levels are associated with increased atherosclerotic cardiovascular disease (ASCVD), in part attributed to elevated inflammation. High Lp(a) inversely correlate apolipoprotein [(APO(a)] isoform size. APO(a) size is negatively production rate (PR) positively fractional catabolic (FCR). We asked whether PR FCR (kinetics) of interleukin (IL)-6 IL-18, pro-inflammatory interleukins that promote ASCVD.MethodsWe used samples from existing data...
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a mouse model that resembles the hyperlipidemia in patients, we here found increased Ia. These data provide rationale for investigating larger patient cohort.
Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-adrenergic receptors (α-ARs). Plasma membrane cholesterol may affect α 1 -AR signaling, but consequences for SMC-mediated are unclear. Cholesterol loading promotes SMC to macrophage transition in vitro , which enhance atherosclerotic plaque vulnerability. However, the role of ATP Binding Cassette A1 and G1 (ABCA1/G1)-cholesterol efflux pathways atherogenesis remains poorly understood. We generated...