A5043051746- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Crystallography and molecular interactions
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Dendrimers and Hyperbranched Polymers
- Carbon dioxide utilization in catalysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Organometallic Complex Synthesis and Catalysis
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Influenza Virus Research Studies
- Polymer Surface Interaction Studies
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Asymmetric Hydrogenation and Catalysis
- Blood properties and coagulation
- Catalysis for Biomass Conversion
- Venous Thromboembolism Diagnosis and Management
- Antimicrobial agents and applications
- Pharmacological Effects and Toxicity Studies
- Chemical Synthesis and Reactions
University of British Columbia
2016-2024
Precision Nanosystems (Canada)
2022-2023
Bloodworks Northwest
2023
University of North Dakota
2012-2020
Cornell University
2012-2020
Emory University Hospital
2018
Vancouver Biotech (Canada)
2017
Indian Institute of Technology Guwahati
2007
A family of chiral zinc amido-oxazolinate complexes are shown to be highly active and isoselective initiators for the ring-opening polymerization (ROP) rac-lactide, yielding isotactic stereoblock polylactides (PLA) with Pm up 0.91. This represents highest isoselectivity observed zinc-based catalysts ROP rac-lactide.
In the pursuit of dendrimer alternatives, hyperbranched polymers have found increasing interest from academia and industry in a broad range fields due to their topological synthetic advantages. Hyperbranched polyglycerol (HPG), as name implies, is polymer with about 50-65% dendrimeric structure. Due its ease synthesis, globular nature, versatility terms functionalization, superb biocompatibility profiles HPG provides promising class materials suitable for numerous applications nanomedicine...
The main viral protease (3CL
Abstract Nanomaterials in the blood must mitigate immune response to have a prolonged vascular residency vivo. The composition of protein corona that forms at nano-biointerface may be directing this, however, possible correlation with is currently unknown. Here‚ we report panel new soft single molecule polymer nanomaterials (SMPNs) varying circulation times mice (t 1/2β ~ 22 65 h) and use proteomics probe elucidate mechanism nanomaterials. opsonins on SMPNs qualitatively quantitatively...
Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that diminish this would have a huge clinical impact. Antithrombotic agents neutralize inhibit polyphosphate (polyP) can be powerful approach towards such goal. Here, we report design concept polyP inhibition, termed macromolecular polyanion inhibitors (MPI), with high binding affinity specificity. Lead...
The introduction of cell-based therapies has provided new and unique strategies to treat many diseases disorders including the recent approval CAR-T cell therapy for leukemia. Cell surface engineering is a methodology in which tailored modulate cellular function interactions. In addition genetic proteins, wide array robust, innovative elegant approaches have been developed selectively target surface. this review, we will introduce leading currently used broadly reactive chemical ligations...
We report the synthesis, characterization, activity, and biocompatibility of a novel series antimicrobial peptide–polymer conjugates. Using parent peptide aurein 2.2, we designed array (∼100 peptides) with single multiple W R mutations identified peptides (AMPs) potent activity against Staphylococcus aureus (S. aureus). These AMPs were conjugated to hyperbranched polyglycerols (HPGs) different molecular weights number improve their toxicity. The cell blood compatibility studies these...
Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need anticoagulant use, thereby reducing unwanted bleeding. Here, by optimizing interactions factor XII rather than preventing its surface adsorption, we develop a substrate-independent antithrombotic polymeric coating sheltered positive charges. The antithrombic properties of...
Abstract Quantification of iron is an important step to assess the burden in patients suffering from overload diseases, as well tremendous value understanding underlying role pathophysiology these diseases. Current determination total or labile iron, requires extensive sample handling and specialized instruments, whilst being time consuming laborious. Moreover, there minimal no overlap between quantification methodologies—i.e. requiring entirely separate protocols, techniques instruments....
The long-term prevention of biofilm formation on the surface indwelling medical devices remains a challenge. Silver has been reutilized in recent years for combating due to its indisputable bactericidal potency; however, toxicity, low stability, and short-term activity current silver coatings have limited their use. Here, we report development silver-based film-forming antibacterial engineered (SAFE) assemblies generation durable lubricous antibiofilm without toxicity that was applicable...
Abstract RNA and protein‐based therapeutics constitute almost half of recent drug approvals receive considerable attention within biotechnology industries. Ensuring their stability longevity in the context heat, freezing, lyophilization processes are paramount to a successful deployment. However, advancement formulations designed achieve this goal is still its nascent phase. To address these challenges, new class semi‐dendritic hydrophilic polymer with extended linear units reported, which...
The synthesis and characterization of a series chiral zinc complexes (L1a–m)ZnN(SiMe3)2 (2a–m) with C1-symmetric amido-oxazolinate ligands (HL1a–m = 2-(2′-R1NH)phenyl-4-R2-oxazoline) have been described. Single-crystal X-ray crystallographic studies confirm that 2a (R1 2,6-dimethylphenyl, R2 (S)-iPr) 2d (R)-iBu) are three-coordinate, mononuclear complexes, 2k PhCO, exists as an amide oxygen-bridged dimer in the solid state distorted tetrahedral geometry. These viable initiators for...
Hydrosilylation catalyzed by a high-valent nitridoruthenium(VI) compound, [RuN(saldach)(CH3OH)]+[ClO4]− (1, where saldach is the dianion of racemic N,N′-cyclohexan-diyl-bis(salicylideneimine)) described. Using phenylsilane as reductant, variety unsaturated organic substrates, including aldehydes, ketones, and imines, are effectively reduced to alcohols amines, respectively, accompanied redistribution PhSiH3 at silicon. Mechanistic studies indicate that catalysis proceeds via silane...
A series of dimethylaluminum complexes (L1a-i )AlMe2 (2a-i, where HL1a-i = 2-(2'-ArNH)phenyl-4-R1-oxazoline) bearing chiral, bidentate anilido-oxazolinate ligands have been prepared and characterized. Six the complexes, in presence an alcohol cocatalyst, are shown to be active initiators for stereoselective ring-opening polymerization rac-lactide toluene solution under bulk conditions, yielding polylactides with a range tacticity from slightly isotactic moderately heterotactic. The...
Abstract A longstanding goal in science and engineering is to mimic the size, structure, functionality present biology with synthetic analogs. Today, globular polymers of several million molecular weight are unknown, and, yet, these structures expected exhibit unanticipated properties due their compactness, low inter-chain interactions. Here we report gram-scale synthesis dendritic polymers, mega hyperbranched polyglycerols (mega HPGs), daltons. The HPGs highly water soluble, soft,...
Heparins are widely used to prevent blood clotting during surgeries and for the treatment of thrombosis. However, bleeding associated with heparin therapy is a concern. Protamine, only approved antidote unfractionated (UFH) could cause adverse cardiovascular events. Here, we describe unique molecular design in development synthetic dendritic polycation named as universal reversal agent (UHRA), an all clinically anticoagulants. We elucidate mechanistic basis selectivity UHRA heparins its...
Chronic transfusion of red blood cells (RBCs) to patients with β-thalassemia, sickle cell disease, and other acquired anemic disorders generates significant amounts bioactive iron deposits in the body. The inactivation excretion redox active iron(III) from pool organs are critical prevent organ damage, focus chelation therapy (ICT) using low molecular weight Fe(III) specific chelators. However, current ICT is suboptimal because short circulation time chelators, toxicity, severe side effects,...
Abstract Polyesters have been widely applied owing to their biodegradability and biocompatibility. Recently, catalytic ring‐opening copolymerization of cyclic anhydrides epoxides has emerged as an effective approach for the synthesis polyesters. Herein, we report a series amido–oxazolinate zinc complexes highly active catalysts styrene oxide anhydrides. Turnover frequencies up 4000 h −1 were achieved in reaction maleic anhydride. Analysis end groups provides useful probe preference at...
Abstract Multivalent binding inhibitors are a promising new class of antivirals that prevent virus infections by inhibiting to cell membranes. The design these is challenging as many properties, for example, inhibitor size and functionalization with attachment factors, strongly influence the inhibition efficiency. Here, synthesized, which inspired mucins, naturally occurring glycosylated proteins high molecular weight (MDa range) interact efficiently various viruses. Hyperbranched...