A5083914721- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Glaucoma and retinal disorders
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Parkinson's Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Retinal and Optic Conditions
- Neurological disorders and treatments
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Mitochondrial Function and Pathology
- Ophthalmology and Visual Health Research
- Retinal Development and Disorders
- Myasthenia Gravis and Thymoma
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Neurological diseases and metabolism
- Advanced Neuroimaging Techniques and Applications
- Visual perception and processing mechanisms
- Peripheral Neuropathies and Disorders
University of Coimbra
2016-2025
Hospitais da Universidade de Coimbra
2012-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
University of Lisbon
2019-2023
Centro Hospitalar de Lisboa Ocidental
2023
Maroc Numeric Cluster
2023
Hospital de Santo Espirito de Angra do Heroísmo
2023
Hospital de Santa Maria
2019
Faculty (United Kingdom)
2019
Jacksonville College
2017
<h3>Importance</h3> The sensitivity of acetylcholine receptor (AChR) antibody testing is thought to be lower in ocular myasthenia gravis (OMG) compared with generalized disease, although estimates small-scale studies vary. There little information the literature about implications AChR levels and progression from OMG gravis. <h3>Objectives</h3> To test hypothesis that serum more sensitive than previously reported examine association between <h3>Design, Setting, Participants</h3> A...
PolyQ ATXN3 is a pharmacodynamic marker for SCA3, and SNP associated with the expanded allele may serve to specifically target mutant .
Abstract Background Despite the benefits of metabolic and bariatric surgery (MBS), not all patients can maintain sustained weight loss in long term. There is increasing awareness that regain (WR) a common issue following MBS. However, WR defined using various criteria, which makes it challenging to understand its prevalence clinical impact after As result, factors contribute before, during, are well understood. This study aims assess at two-years surgery, four definitions, identify...
Abstract Background In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its microbiota in disease. Recent evidence suggests may trigger body - first Parkinson Disease (PD), yet underlying mechanisms remain unclear. This study aims to elucidate how a dysbiotic microbiome through immune alterations triggers PD related neurodegeneration. Methods To determine impact of on development progression pathology, wild-type male C57BL/6 mice...
<h3>Background and Objectives</h3> The <i>RFC1</i> spectrum has become considerably expanded as multisystemic features beyond the triad of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) have started to be unveiled, although many still require clinical replication. Here, we aimed clinically characterize a cohort <i>RFC1</i>-positive patients by addressing both classic features. In second part this study, prospectively assessed small nerve fibers (SNF) autonomic function...
Ocular neuromyotonia is a rare, albeit treatable, ocular motor disorder, characterised by recurrent brief episodes of diplopia due to tonic extraocular muscle contraction. Ephaptic transmission in chronically damaged nerve the possible underlying mechanism. It usually improves with carbamazepine. A 53-year-old woman presented 4-month history binocular vertical (up 40/day), either spontaneously or after sustained downward gaze. Between she had mild left fourth palsy. Sustained gaze...
The link between synaptic plasticity and reorganization of brain activity in health disease remains a scientific challenge. We examined this question Parkinson's (PD) where functional up-regulation postsynaptic D2 receptors has been documented while its significance at the neural level never identified. investigated cortico-subcortical PD using oculomotor system as model to study dopaminergic networks. This is ideal because reorganizes due frontal-to-parietal shifts blood oxygen...
Abstract: An immune attack by anti–glutamic acid decarboxylase (GAD) antibodies is believed to cause a deficiency in gamma-aminobutyric acid–mediated neurotransmission the cerebellum. This, turn, leads several eye movement disorders, including spontaneous downbeat (DBN) and periodic alternating nystagmus. We describe 68-year-old diabetic woman with disabling paroxysmal positioning upbeat nystagmus (UBN) exclusively supine position, associated asymptomatic DBN, skew deviation hyperactive...
Accurate clinical differentiation between skew deviation and fourth nerve palsy (4NP) is critical in the acute subacute settings.To determine sensitivity specificity of upright-supine test to detect vertical misalignment changes using different head positions for diagnosis or vs 4NP.This multicenter study enrolled consecutive patients from Coimbra University Hospital Centre, Coimbra, Portugal, Michigan State University, Lansing, within 2 months presenting with diplopia diagnosed as having...
Objective: To evaluate the utility of positional testing in peripheral and central acute vestibular syndrome (pAVS, cAVS, respectively). Study design: Prospective; observational. Setting: Tertiary referral center. Patients: Consecutive AVS patients. Interventions: Video-oculography upright, supine head hanging positions at presentation, 3-month 1-year follow-up. Main Outcome Measures: Positional modulation spontaneous nystagmus; co-occurrence paroxysmal nystagmus (CPPN). Results: Fifteen...
Abstract Usher Syndrome classification takes into account the absence of vestibular function but its correlation with genotype is not well characterized. We intend to investigate whether video Head Impulse Test (vHIT) useful in screening and differentiate types. 29 patients (USH) a genetically confirmed diagnosis 30 healthy controls were studied vHIT dizziness handicap inventory questionnaire (DHI). Statistical significant differences between USH1, USH2 found vestibulo-ocular-reflex (VOR)...
To explore postural disability in Usher Syndrome (USH) patients using temporal posturographic analysis to better elucidate sensory compensation strategies of deafblind for posture control and correlate the Activities-specific Balance Confidence (ABC) scale with variables.