A5040798661- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Pregnancy and preeclampsia studies
- Ship Hydrodynamics and Maneuverability
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Blood groups and transfusion
- Coastal and Marine Dynamics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Wave and Wind Energy Systems
- Cavitation Phenomena in Pumps
- Urinary Tract Infections Management
- Ethics and Legal Issues in Pediatric Healthcare
- Methemoglobinemia and Tumor Lysis Syndrome
- Cardiovascular Health and Risk Factors
- Teratomas and Epidermoid Cysts
- Head and Neck Surgical Oncology
- Aquatic and Environmental Studies
- Diagnosis and treatment of tuberculosis
- Hypothalamic control of reproductive hormones
- Structural Integrity and Reliability Analysis
- Healthcare Decision-Making and Restraints
- Diabetes Management and Research
- Prenatal Screening and Diagnostics
Hôpital Robert-Debré
2013-2024
Assistance Publique – Hôpitaux de Paris
2010-2024
Evaluation et recherche en services et politiques en santé pour les populations vulnérables
2016-2024
Inserm
2014-2021
Université Paris Cité
2013-2021
Délégation Paris 7
2014-2017
Sorbonne Paris Cité
2016-2017
Délégation Paris 5
2013
École Navale
1970
Despite the number of reported data concerning idiopathic central precocious puberty (CPP) in girls, major questions remain including its diagnosis, factors, and indications gonadotropin releasing hormone (GnRH) analog treatment.A retrospective, single-center study was carried out on 493 girls with CPP.Eleven (2.2%) were aged less than 3 years. Breast development either isolated (Group 0, n = 99), or associated one sign, pubic hair development, growth rate greater 2 standard deviation score...
Summary Children with sickle cell disease ( SCD ) have a significant vascular morbidity, especially cerebral macrovasculopathy CV ), detectable by transcranial Doppler. This study aimed to identify risk factors for using longitudinal biological and clinical data in newborn cohort followed at the Robert Debre Reference centre n = 375 SS /Sβ 0 ). Median follow‐up was 6·8 years (2677 patient‐years). Among 59 children presenting , seven had stroke. Overall, incidence of 2·20/100 patient‐years...
BACKGROUND Chronic exchange transfusion is effective for primary and secondary prevention of stroke in children with sickle cell anemia (SCA). Erythrocytapheresis recognized to be the most efficient approach; however, it not widely implemented suitable all patients. The aim our study was compare automated (AET) manual method and, particular, evaluate efficacy, safety, cost method. STUDY DESIGN AND METHODS Thirty‐nine SCA and/or abnormal findings on transcranial Doppler were included study....
Background The incidence of invasive group A streptococcus (GAS) infections is increasing worldwide, whereas there has been a dramatic decrease in pneumococcal diseases. Few data describing GAS pleural empyema children are available. Objective To describe the clinical and microbiological features, management outcome compare them with those empyema. Design, setting patients Fifty admitted for between January 2006 May 2013 to 8 hospitals participating national pneumonia survey were included...
Background Acute chest syndromes (ACS) may be associated with upper respiratory tract infections, but the epidemiology of viral and intracellular pathogens in children sickle cell disease (SCD) is not precisely known. The aim this study was to describe SCD presenting fever and/or ACS. Materials methods An observational, prospective, single-centre cohort nested case–control analysis conducted on admitted from October 2016 2017 for ACS paediatric department Robert Debré university hospital,...
<h3>Objective</h3> To examine morbidity among children with sickle-cell disease (SCD) during and after travel to a tropical area. <h3>Design</h3> Observational study. <h3>Setting</h3> Tertiary care children; Robert Debré Hospital, Paris, France. <h3>Population</h3> Children SCD younger than 18 years old managed in the referral centre at Hospital who travelled or subtropical area between 1 June 2009 31 December 2009. <h3>Main outcome</h3> assess morbidity, we used number of clinical events...
Sickle cell disease (SCD) is one of the most frequent inherited diseases in world. Over last decades, high-income countries, an important decrease mortality have been observed due to improvement care. However, children with SCD can become critically ill and require admission Pediatric Intensive Care Units (PICU). The purpose this study was describe epidemiology admitted PICU for acute crisis identify factors associated adverse outcome (AO).
Nitrous oxide (N2O) is widely used as an anesthetic or analgesic. N2O prolonged and recurrent administration known to affect vitamin B12 metabolism with subsequent clinical consequences. We report herein the case of a 13-year-old girl sickle cell disease exhibiting severe neurological biochemical signs functional deficiency due repeated exposure N2O. This was incentive prospectively investigate in patients affected by regularly exposed measured plasma concentrations B12, total homocysteine,...
Transient neonatal diabetes mellitus (TNDM) occurs during the 1st year of life and remits childhood. We investigated glucose metabolism socioeducational outcomes in adults.We included 27 participants with a history TNDM currently (n = 24) or without 3) relapse 16 non-TNDM relatives known to be carriers causal genetic defects 9) 7) diabetes. Insulin sensitivity secretion were assessed by hyperinsulinemic-euglycemic clamp arginine-stimulation testing subset 8 7 carrying abnormalities,...
Background The number of trips to the tropics taken by children with chronic health disorders (CHDs) is increasing. Methods All CHDs who attended two international vaccination centres in France before travelling were included a prospective, exposed/unexposed study. Each child was age-matched control and followed for 1 month after returning from tropics. Results Fifty-six 107 included. children's median age 6 years old (IQR 2–11). Of study participants, 127/163 (78%) travelled West Africa,...
To read the full abstract: Diabetes Care. 2020 Apr 9. pii: dc190324. doi: 10.2337/dc19-0324. [Epub ahead of print]. PMID: 32273272
Background and aims: Unplanned extubation (UE) is a potentially serious complication that can contribute to increased patient morbidity mortality. Few studies have assessed UE in paediatric intensive care. Aims: We monitored for 4-year period determine the incidence contributing factors aiming develop quality improvement programs. Methods: Data on were collected prospectively from January 1, 2010, September 30, 2013 16-bed tertiary The Institutional Review Board approved study waived need...
Aims & Objectives: Pediatric sepsis remains a burdensome public health problem, especially in patients with immuno-deficiency. Adherence to Survival Sepsis Campaign (SSC) would be associated lower mortality. However, this correlation had never been evaluated children hematologic malignancies. Methods Retrospective bicentric cohort study of identified malignancy or hematopoietic stem cell transplantation and requiring intensive care for severe between January 2011 August 2017. Description...