A5040587852- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Retinal Diseases and Treatments
- Long-Term Effects of COVID-19
- Atherosclerosis and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Pharmacology and Obesity Treatment
- Cholesterol and Lipid Metabolism
- Endoplasmic Reticulum Stress and Disease
- Biomarkers in Disease Mechanisms
- Retinal Imaging and Analysis
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Retinopathy of Prematurity Studies
Institut Necker Enfants Malades
2022-2025
Hôpital Lariboisière
2019-2025
Université Paris Cité
2019-2025
Assistance Publique – Hôpitaux de Paris
2019-2025
Inserm
2019-2025
Centre de Recherche des Cordeliers
2019-2024
Hôpital Fernand-Widal
2022-2024
Centre National de la Recherche Scientifique
2022-2024
Sorbonne Paris Cité
2020-2024
Sorbonne Université
2019-2023
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis (AF) remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter, prospective study assessed the yield of using routinely available data to identify these patients. RESEARCH DESIGN AND METHODS A total 713 outpatients T2DM, screened four diabetology clinics fatty liver disease according American Diabetes Association criteria, were referred...
Abstract Aims Recent trials provide conflicting results on the association between glucagon-like peptide 1 receptor agonists (GLP-1RA) and diabetic retinopathy (DR). The aim of AngioSafe type 2 diabetes (T2D) study was to determine role GLP-1RA in angiogenesis using clinical preclinical models. Methods We performed two studies humans. In 1, we investigated effect exposure from T2D diagnosis severity DR, as diagnosed with retinal imaging (fundus photography). 2, a randomized 4-week trial,...
Early in the COVID-19 pandemic, type 2 diabetes (T2D) was marked as a risk factor for severe disease and mortality. Inflammation is central to aetiology of both conditions where variations immune responses can mitigate or aggravate course. Identifying at-risk groups based on immunoinflammatory signatures valuable directing personalised care developing potential targets precision therapy. This observational study characterised immunophenotypic variation associated with severity T2D....
Objective: The use of continuous glucose monitoring (CGM) systems and subcutaneous insulin infusion (CSII) devices adhering to the skin can lead reactions. objective was determine prevalence consequences reactions at CGM or CSII sites in a large unbiased population. Research Design Methods: This is cross-sectional multicenter study. All adult patients with diabetes seen consultation over period 7 months using having used system adhesives (in last 10 years) were included filled out...
Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate cardiovascular events. While cholesterol accumulation in atheroma plaque macrophages a major driver inflammatory process, role LXR sensors remains to be clarified. Murine human were treated with agonists for 48 h before Toll-like receptor (TLR) stimulation. Unexpectedly, we observe that, among other cytokines, selectively increase IL1B mRNA levels...
Abstract Background Achieving an in-range glycated haemoglobin (HbA1c) is essential for managing diabetes mellitus (DM). However, this parameter provides estimate of long-term blood glucose control rather than daily glycaemic variations. Glycaemic variability can be more predictive HbA1c in terms identifying those at risk complications, including severe respiratory virus infections and usually measured via a continuous monitor (CGM). For individuals whom CGM not available, serum 1,5...
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) which the main cause vision loss in working-age population. Currently known risk factors such as age, disease duration, and hemoglobin A1c lack sufficient efficiency to distinguish patients with early stages DR. A total 194 plasma samples were collected from type 2 DM DR (moderate proliferative (PDR) or control (no mild DR) matched for gender, HbA1c, hypertension. Untargeted lipidomic metabolomic approaches...
Estimating glycemic variability (GV) through within-day coefficient of variation (%CVw) is recommended for patients with type 1 Diabetes (T1D). High GV (hGV) defined as %CVw > 36%. However, continuous glucose monitoring (CGM) devices provide exclusively total CV (%CVT). We aimed to assess consequences this disparity.We retrospectively calculated both %CVT and consecutive T1D from their CGM raw data during 14 days. Patients hGV >36% ≤36% were called the "inconsistent group".A 104 included....
Some women living with type 1 diabetes complain of changes in glucose values according to the different phases menstruation.To evaluate this variability through continuous monitoring (CGM) data patients.Observational study.Ambulatory data, recruitment 2 centers Paris region.Twenty-four having spontaneous menstrual cycles.Collection CGM for 62 cycles, evaluation five 3-day during each cycle: (1) early follicular (menstruations), (2) mid-follicular, (3) peri-ovulatory, (4) mid-luteal, and (5)...
The aim of this study (EPIDIAB) was to assess the relationship between epicardial adipose tissue (EAT) and micro macrovascular complications (MVC) type 2 diabetes (T2D). EPIDIAB is a post hoc analysis from AngioSafe T2D study, which multicentric aimed at determining safety antihyperglycemic drugs on retina including patients with screened for diabetic retinopathy (DR) (n = 7200) deeply phenotyped MVC. Patients included who had undergone cardiac CT CAC (Coronary Artery Calcium) scoring after...
Adipose tissue macrophages (ATM) adapt to changes in their energetic microenvironment. Caloric excess, a range from transient diet-induced obesity, could result the transition of ATMs highly oxidative and protective inflammatory metabolically deleterious. Here, we demonstrate that Interferon Regulatory Factor 5 (IRF5) is key regulator macrophage capacity response caloric excess. mice with genetic-deficiency Irf5 are characterised by increased respiration mitochondrial membrane potential....
Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with 2-fold higher of events in people diabetes compared those without. Circulating monocytes are inflammatory effector cells involved both type 2 (T2D) and atherogenesis.
OBJECTIVE Bone biopsy (BB) performed by a surgeon or an interventional radiologist is recommended for suspicion of osteomyelitis underlying diabetic foot ulcer (DFU). To facilitate its practice, we developed procedure allowing bedside blind bone (B4) diabetologist. RESEARCH DESIGN AND METHODS We conducted three-step observational study consisting feasibility and safety phase (phase 1) to assess the success side effects B4, validity 2) compare DFU outcomes between positive (B4+) negative...
Sudomotor dysfunction is one of the earliest manifestations small fiber neuropathy (SFN), reflecting alteration sympathetic C innervation sweat glands. Among other techniques, such can be assessed by measuring electrochemical skin conductance (ESC) in microsiemens (μS). In this study, ESC was measured at feet to detect distal SFN. For objective, performance a new device, Body Scan® (Withings, France), intended for home use, compared with that reference Sudoscan® (Impeto Medical, which...
Glycemic variability remains frequent in patients with type 1 diabetes treated insulin pumps. Heterogeneous spreads of infused by pump the subcutaneous (SC) tissue are suspected but were barely studied. We propose a new real-time ex-vivo method built combining high-precision imaging simultaneous pressure measurements, to obtain follow-up propagation. Human skin explants from post-bariatric surgery imaged micro-computed tomography scanner, optimised parameters reach one 3D image every 5 min...
Transient neonatal diabetes mellitus (TNDM) occurs during the 1st year of life and remits childhood. We investigated glucose metabolism socioeducational outcomes in adults.We included 27 participants with a history TNDM currently (n = 24) or without 3) relapse 16 non-TNDM relatives known to be carriers causal genetic defects 9) 7) diabetes. Insulin sensitivity secretion were assessed by hyperinsulinemic-euglycemic clamp arginine-stimulation testing subset 8 7 carrying abnormalities,...
<p> </p> <p><strong>OBJECTIVE</strong></p> <p>Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective study aimed at assessing the yield of using routinely available data identifying these patients.</p> <p><strong>RESEARCH DESIGN AND METHODS</strong></p> <p>A total...
Introduction: Most continuous subcutaneous insulin infusion (CSII) catheters (KT) are changed every 3 days. This study aims at evaluating whether KT changes impact glucose control while under open-loop (OL) or automated delivery (AID) modes.