A5059223297- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Genomics and Phylogenetic Studies
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Reconstructive Surgery and Microvascular Techniques
- Single-cell and spatial transcriptomics
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Genetics, Bioinformatics, and Biomedical Research
- Melanoma and MAPK Pathways
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Bioinformatics and Genomic Networks
- Glycosylation and Glycoproteins Research
IBM (United States)
2019-2024
IBM Research - Thomas J. Watson Research Center
2018-2023
Alliance for Safe Kids
2019
Icahn School of Medicine at Mount Sinai
2010-2014
American Society of Plastic Surgeons
2012
Mount Sinai Medical Center
2012
Stony Brook University Hospital
2012
NewYork–Presbyterian Hospital
2012
New York University
2011-2012
UCLA Medical Center
2012
Sacituzumab govitecan (SG), the first antibody-drug conjugate (ADC) approved for triple-negative breast cancer, incorporates anti-TROP2 antibody hRS7 conjugated to a topoisomerase-1 (TOP1) inhibitor payload. We sought identify mechanisms of SG resistance through RNA and whole-exome sequencing pretreatment postprogression specimens. One patient exhibiting de novo progression lacked TROP2 expression, in contrast robust expression focal genomic amplification TACSTD2/TROP2 observed with deep,...
Background: Fat grafting has emerged as a useful method for breast contouring in aesthetic and reconstructive patients. Advancements have been made fat graft harvest delivery, but the ability to judge overall success of remains limited. The authors applied three-dimensional imaging technology assess volumetric survival following autologous transfer breast. Methods: surgery was performed using modified Coleman technique reconstruction. Patients undergoing procedure were entered into study...
Abstract Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy chronic lymphocytic leukemia (CLL), but continuous has been complicated by development resistance. The most common resistance mechanism in patients whose disease progresses on covalent BTK (BTKis) is a mutation 481 cysteine residue to which bind covalently. Pirtobrutinib highly selective, noncovalent BTKi with substantial clinical activity progressed BTKi, regardless status. Using vitro...
Acral melanoma, the most common melanoma subtype among non-White individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we perform integrative genomic and clinical profiling of acral melanomas from 104 patients treated in North America (n = 37) or China 67). We find that recurrent, late-arising focal amplifications cytoband 22q11.21 are a leading determinant inferior survival, strongly metastasis, linked to downregulation immunomodulatory...
Nipple-sparing mastectomy (NSM) as a therapeutic or prophylactic procedure for breast cancer is rapidly gaining popularity the literature continues to support it safety. The lateral inframammary fold (IMF) approach provides adequate exposure and eliminates visible scars on anterior surface of breast, making this incision cosmetically superior radial periareolar approaches. We reviewed 55 consecutive NSMs performed through IMF with immediate implant-based reconstruction, without tissue...
Only a minority of those exposed to human papillomavirus (HPV) develop HPV-related cervical and oropharyngeal cancer. Because host immunity affects infection progression cancer, we tested the hypothesis that genetic variation in immune-related genes is determinant susceptibility cancer other HPV-associated cancers by performing multitier integrative computational analysis with data from head neck genome-wide association study (GWAS). Independent analyses, including single-gene,...
Abstract Although the development of multiple primary tumors in smokers with lung cancer can be attributed to carcinogen-induced field cancerization, occurrence at presentation individuals EGFR -mutant who lack known environmental exposures remains unexplained. In present study, we identified ten patients early stage, resectable, non-small cell presented multiple, anatomically distinct, tumors. We analyzed phylogenetic relationships among from each patient using whole-exome sequencing (WES)...
Sampling circulating tumor DNA (ctDNA) using liquid biopsies offers clinically important benefits for monitoring cancer progression. A single ctDNA sample represents a mixture of shed from all known and unknown lesions within patient. Although shedding levels have been suggested to hold the key identifying targetable uncovering treatment resistance mechanisms, amount by any one specific lesion is still not well characterized. We designed Lesion Shedding Model (LSM) order strongest poorest...
Recent genomic and bioinformatic advances have motivated the development of numerous network models intending to describe graphs biological, technological, sociological origin. In most cases success a model has been evaluated by how well it reproduces few key features real-world data, such as degree distributions, mean geodesic lengths, clustering coefficients. Often pairs can reproduce these with indistinguishable fidelity despite being generated vastly different mechanisms. cases, target...
The confluence of deep sequencing and powerful machine learning is providing an unprecedented peek at the darkest dark genomic matter, non-coding regions lacking any functional annotation. While uncovers rare tumor variants, heterogeneity disease confounds best (ML) algorithms. Here we set out to answer if dark-matter genome encompass signals that can distinguish fine subtypes are otherwise genomically indistinguishable. We introduce a novel stochastic regularization, ReVeaL, empowers ML...
Abstract Background Datasets generated on deep-sequencing platforms have been deposited in various public repositories such as the Gene Expression Omnibus (GEO), Sequence Read Archive (SRA) hosted by NCBI, or DNA Data Bank of Japan (ddbj). Despite being rich data sources, they not used much due to difficulty locating and analyzing datasets interest. Results Geoseq http://geoseq.mssm.edu provides a new method short reads from deep sequencing experiments. Instead mapping reference genomes...
Abstract Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies. Approximately half patients with refractory large B-cell lymphomas achieve durable responses from CD19-targeting CAR-T treatment; however, failure mechanisms are identified in only a fraction cases. To gain novel insights into basis clinical response, we performed single-cell transcriptome sequencing 105 pre- and post-treatment peripheral blood mononuclear samples, infusion...
All diseases containing genetic material undergo evolution and give rise to heterogeneity including cancer infection. Although these illnesses are biologically very different, the ability for phylogenetic retrodiction based on genomic reads is common between them thus tree-based principles assumptions shared. Just as different frequencies of tumor variants presupposes existence multiple clones provides a handle computationally infer them, we postulate that variant in viral offers means...
The emergence of COVID-19 (C19) created incredible worldwide challenges but offers unique opportunities to understand the physiology its risk factors and their interactions with complex disease conditions, such as metabolic syndrome. To address discovering clinically relevant interactions, we employed a approach for epidemiological analysis powered by redescription-based topological data (RTDA).
Abstract Background. Despite substantial progress in the treatment of HER2+ MBC, most patients (pts) still experience disease progression and cancer-related death. HER2-directed TKIs are highly effective therapies for pts with MBC; however, an understanding resistance mechanisms is needed. Pts receiving cell-free DNA (cfDNA) sampling across spectrum present a unique opportunity to examine genomic alterations. Methods. biopsy-proven MBC were selected from DF/HCC approved protocols ultra-low...
INTRODUCTION: Radiation therapy for breast cancer alters underlying tissue perfusion, which can result in skin discoloration and fibrosis of the reconstructed breast. Management these deformities remains a challenge, but fat grafting (FG) has emerged to correct symmetry radiated Advancements have been made techniques graft harvest delivery, our ability judge incorporation FG limited. The following study applies 3D imaging assess stability shape autologous METHODS: All patients receiving from...