A5081548769- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Probiotics and Fermented Foods
- Meta-analysis and systematic reviews
- Brucella: diagnosis, epidemiology, treatment
- Streptococcal Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Ultrasound in Clinical Applications
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 detection and testing
- Travel-related health issues
- Neonatal and Maternal Infections
- Burkholderia infections and melioidosis
- Veterinary medicine and infectious diseases
- Plant pathogens and resistance mechanisms
- COVID-19 Clinical Research Studies
- Listeria monocytogenes in Food Safety
- Cardiovascular Health and Disease Prevention
Khoo Teck Puat Hospital
2013-2023
Pt. Jawahar Lal Nehru Memorial Medical College
2019
Amrita Institute of Medical Sciences and Research Centre
2018
Post Graduate Institute of Medical Education and Research
2018
Singapore General Hospital
2007-2014
Since 2010, the incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing in Singapore. We analyzed clinical and molecular epidemiology CRE among adult inpatients Singapore.Quarterly unique subjects (per 100000 patient-days) with positive surveillance cultures for were estimated based on mandatory data submitted to National Public Health Laboratory by public hospitals between 2010 2015. CRE-positive prospectively recruited from 6 sector December 2013 April Subjects...
Abstract Carbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in hospital transmit to other patients who stay same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals Singapore, we analysed 779 acquired CPE (1215 isolates) by clinical or surveillance cultures. 42.0% met putative...
Carbapenem-resistant Enterobacteriaceae (CRE) can be mechanistically classified into carbapenemase-producing (CPE) and non-carbapenemase-producing carbapenem nonsusceptible (NCPCRE). We sought to investigate the effect of antecedent exposure as a risk factor for NCPCRE versus CPE. Among all patients with CRE colonization infection, we conducted case-control study comparing (cases) CPE (controls). The presence carbapenemases was investigated phenotypic tests followed by PCR predominant...
Owing to gene transposition and plasmid conjugation, New Delhi metallo-β-lactamase (NDM) is typically identified among varied Enterobacteriaceae species STs. We used WGS characterize the chromosomal molecular epidemiology of NDM transmission involving four institutions in Singapore. Thirty-three isolates (collection years 2010–14) were sequenced using short-read sequencing-by-synthesis analysed. Long-read single molecule, real-time sequencing (SMRTS) was genetically a novel pSg1-NDM carried...
Sixty unique clinical isolates previously reported as Burkholderia pseudomallei were run in parallel through the API 20NE and VITEK 2 GN identification systems after 24h growth on Columbia agar with 5% sheep blood. The identifications confidence levels determined by each test modality compared. identified 47 (78.3%) 52 (86.7%) of B. pseudomallei. modal octal profile for latter was 1156577. alternative most commonly made both cepacia. Comparison two modalities gave a Cohen's κ 0.6008,...
At the time of study, 3 plasmid-borne qnr determinants (qnrA, qnrB and qnrS) 1 aminoglycoside-modifying enzyme determinant that confers quinolone resistance (aac(6')-Ib-cr) had been described in literature.We studied prevalence a total 117 nalidixic acid-resistant urinary isolates Klebsiella pneumoniae (61 isolates) Escherichia coli (56 using multiplex polymerase chain reaction (PCR). Further, subset original strains (comprising 14 E. 38 K. pneumoniae) showing reduced susceptibility to...
Commonly occurring health hazards associated with the Hajj have been well described in literature. However, there remain other serious but less known risks. We present here 2 cases of brucellosis contracted from drinking unpasteurised camel's milk during Hajj.
Abstract We report a fatal autochthonous diphtheria case in migrant worker Singapore. This highlights the risk for individual cases undervaccinated subpopulations, despite high vaccination coverage general population. Prompt implementation of public health measures and maintaining immunization are critical to prevent reemergence diphtheria.
Rat-bite fever (RBF) is a rare but potentially fatal zoonotic disease that has resurfaced in literature from time to time. RBF conventionally been attributed Streptobacillus moniliformis the Western World and Spirillum minus Asia. However, numerous case reports of Asia highlight need rethink this assertion. We encountered patient with streptobacillary history recent travel Bangladesh. present salient clinical features processes arriving at diagnosis. The was successfully treated no major...
Abstract The COVID-19 pandemic led to an initial increase in the incidence of carbapenem-resistant Enterobacterales (CRE) from clinical cultures South-East Asia hospitals, which was unsustained as progressed. Conversely, there a decrease CRE surveillance and overall combined incidence. Further studies are needed for future preparedness.
Limitation in use of pulse pressure variation (PPV) predicting fluid responsiveness (FR) hypotensive patients is encountered when values are the "gray zone" (8-13%). Dynamic arterial elastance (Eadyn= PPV/SVV) can be used such situations to predict response volume expansion (VE). In our study, we respiratory ascending aorta velocity time integral (AoVTI) calculated from suprasternal window as a surrogate stroke (SVV). Fluids/vasopressors were administered intraoperatively based on value...
Background: To compare esmolol, labetalol and metoprolol in attenuating the cardiovascular response of L&I.Subjects Methods: It was a randomized prospective study 120 patients 18-60 years, ASA grade I II, either sex, posted for elective surgery under GA.After approval from ethical committee informed written consent, were randomly allocated four groups 30 each.Group C (control) received 10 ml 0.9% saline, group E esmolol 0.5 mg/kg (both 2min prior to induction), Group L 0.25 M 0.1 5min...
Bacterial peritonitis remains a significant cause of mortality in patients on peritoneal dialysis (PD). Early detection causative organisms and targeted antimicrobial treatment allow for better clinical outcomes. This study compares bacterial growth results from dialysate the BACTEC blood culture system vs. conventional culture.We conducted prospective 46 with 63 consecutive episodes suspected PD between August 2020 2021. was simultaneously sent to laboratory both sterile bottles. bottles...