A5062081725- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Cancer-related cognitive impairment studies
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Patient-Provider Communication in Healthcare
- Uterine Myomas and Treatments
- Palliative Care and End-of-Life Issues
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
Abbotsford Veterinary Clinic
2018-2024
University of British Columbia
2012-2024
BC Cancer Agency
2014-2024
Spinal Cord Injury BC
2023-2024
Saskatchewan Cancer Agency
2016
University of Calgary
2014-2016
McMaster University
2016
Limited data exist on outcomes for metastatic renal cell carcinoma (mRCC) patients treated with multiple lines of therapy. Benchmarks survival are required patient counselling and clinical trial design. Outcomes mRCC from the International Database Consortium database 1, 2, or 3+ targeted therapy (TT) were compared by proportional hazards regression. Overall (OS) progression-free (PFS) calculated using different population inclusion criteria. In total, 2705 TT which 57% received only...
Objectives: Adenoid cystic carcinoma (ACC) is often treated with surgery, or without adjuvant radiation therapy (RT). We evaluated disease characteristics, treatments, and potentially prognostic variables in patients ACC. Methods: Our retrospective analysis considered consecutive cases of ACC presenting at a tertiary care hospital between 2000 2014. Factors predictive overall survival (OS) disease-free (DFS) were identified by univariate analysis. Results: The 60 analyzed had mean age 58...
Purpose The International Germ Cell Cancer Collaborative Group (IGCCCG) criteria prognosticate survival outcomes in metastatic testicular germ cell tumor (MT-GCT), but how the initial risk changes over time for those who survived since curative treatment is unknown. Patients and Methods We assessed patients eligible first-line therapy MT-GCT at five tertiary cancer centers from 1990 to 2012 2-year conditional overall (COS) disease-free (CDFS), defined as probability of surviving, or...
Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of metastatic disease. Little known regarding genomic characteristics and therapeutic targets. We present the clinical, pathologic, genomic, transcriptomic analyses case 27-yr-old male TLFRCC who presented initially bone metastases unknown primary. Genomic DNA from peripheral blood tumor samples were sequenced. A transcriptome 280 million sequence reads was generated same sample. Tumor somatic expression...
Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset not known. This study utilized psychomotor vigilance test (PVT) and trail-making B (TMT-B) to assess cognitive immediately post-chemotherapy. Patients aged 18–80 years first-line intravenous chemotherapy for any stage breast or colorectal cancer were eligible. Patient symptoms, peripheral neuropathy Stanford Sleepiness Scale assessed. A five-minute PVT TMT-B completed on a tablet computer...
Objectives The Serious Illness Conversation Guide (SICG) has emerged as a framework for conversations with patients serious illness diagnosis. This study reports on narratives generated from open-ended questions of novel assessment tool, the Conversation-Evaluation Exercise (SIC-Ex), to assess resident-led in oncology outpatient clinics. Design Qualitative using template analysis. Setting Three academic cancer centres Canada. Participants 7 resident physicians (trainees), clinics, 10...
Introduction: The results of the phase 3 ALSYMPCA trial showed that Radium-223 (Ra-223) improves overall survival (OS) and delays onset first symptomatic skeletal event vs. placebo in patients with metastatic castration-resistant prostate cancer (mCRPC). purpose REACTIVATE study was to inform optimal placement Ra-233 treatment sequence by evaluating clinical outcomes healthcare resource utilization using real-world data from multiple Canadian provinces. Methods: This retrospective cohort...
Introduction: Only approximately 25% of stage iv non-small-cell lung cancer (nsclc) patients receive systemic therapy. For such patients, we examined factors affecting referral to a centre (cc) and medical oncology (mo), use Methods: Using the Glans–Look Lung Cancer database, completed chart review nsclc diagnosed in Southern Alberta during 2003–2006 2010–2011, comparing median overall survival (mos), referral, treatment two cohorts. Results: Of 922 560 94% 82% respectively were referred cc,...
Background: Real-world data on palliative systemic therapies (PST) in treating metastatic bladder cancer (mBC) is limited. This study investigates current trends mBC with first- (1L) and second-line (2L) chemotherapy (CT) immunotherapy (IT). Methods: A chart review was conducted patients diagnosed stage II-IV 2014–2016. Survival outcomes were compared between chemotherapy, immunotherapy, supportive care. Results: out of 297 patients, 77% male. 44% had IV disease at diagnosis. Median age...
Purpose: Oncology centers in public health systems often transfer routine follow-up of patients with early-stage breast cancer (BC) to primary care physicians because the increasing numbers survivors and evidence supporting safety this practice. After care, it is unknown how BC fare treatment surveillance goals, whether they have unmet needs for access specialist care. This study conducted a sample women Alberta, Canada, examined adherence guidelines, symptoms, need telephone-based...
To describe the patient characteristics, patterns of treatment, and outcome patients with small cell carcinoma Cervix (SmCC) treated radical radiotherapy from a provincial cancer registry database.Overall 25 SmCC were (with or without chemotherapy) January 1, 1994 to December 31, 2013. Nineteen had pure while 6 additional neuroendocrine component. Patients combined chemo-radiotherapy using multi-agent chemotherapy pelvic para-aortic radiotherapy. All received brachytherapy. Use prophylactic...
Abstract Background In advanced nasopharyngeal carcinoma (NPC), biomarkers may help predict survival. Methods Tumoral expression of ataxia‐telangiectasia mutated (ATM), thymidylate synthetase (THMS), and ribonucleotide reductase subunit M1 (RRM1), was correlated with survival in patients nonmetastatic NPC using quantitative fluorescence immunohistochemistry automated digital image analysis. Results Of the 146 included, 58 (40%) received concurrent chemoradiation therapy; remainder treated...
398 Background: Prior prognostic models for 2nd-line systemic therapy have not been studied in the setting of contemporary sequential targeted (TT). We sought to validate IMDC model patients with mRCC receiving next-line TT after progression on 1st-line TT. Methods: Patients who received progressing at 19 centres were analyzed. For had immunotherapy (22%) prior their 1st TT, we examined second (ie 3rd-line therapy). The endpoint was median overall survival (OS) since initiation therapy....
Adenoid cystic carcinoma (ACC) is a slow growing salivary gland malignancy that molecularly characterized by t(6:9)(q22–23;p23–24) translocations which predominantly result in MYB-NFIB gene fusions nearly half of tumours. Detection transcripts typically performed with fresh ACC tissue using conventional RT-PCR fragment analysis or FISH techniques, are prone to failure when only archival formalin fixed paraffin embedded (FFPE) available. The purpose this pilot study was evaluate the utility...
Patients with FIGO stage III endometrial cancer routinely receive adjuvant therapy. The purpose of this study was to evaluate overall survival (OS) and disease-free (DFS) in patients IIIA IIIC2 by treatment modality received risk factors.Patients treated from 2000-2010 were identified the provincial registry. Clinicopathologic characteristics, treatments outcomes compared using descriptive multivariable analyses.261 had 3 cancer, 132 IIIA, 9 IIIB, 85 IIIC1 35 IIIC2. 39 grade 1 disease; 73,...
Factors that impact recurrence in stages IB to IV include larger tumor, high-risk histology, older age, and lymphovascular invasion (LVI); however, local studies on risk factors for British Columbia our patterns have not been well studied. Furthermore, the efficacy of treatment modalities including surgery chemoradiation different cervical cancer clarified this population.The purpose study is determine disease characteristics which are associated with survival differences within Columbia.We...
Introduction: Extragonadal germ cell tumours (EGCTs) are a heterogeneous group with distinct natural history and responses to treatmentmodalities. We sought evaluate characteristics survival outcomes in men EGCTs.Methods: performed retrospective analysis on consecutive list of diagnosed EGCT two Albertan cancer centres between 1990 2013. Demographic outcomes, stratified by primary site, were evaluated.Results: Sixty-nine cases identified. The median age was 29 (range 15–76) 48 (70%)...
Background/Objectives: The serious illness conversation (SIC) is an evidence-based framework for conversations with patients about a diagnosis. objective of our study was to develop and validate novel tool, the SIC-evaluation exercise (SIC-Ex), facilitate assessment resident-led oncology patients. Design: We developed SIC-Ex based on SIC Royal College Canada Medical Oncology milestones. Seven resident trainees 10 evaluators were recruited. Each trainee conducted patient, which videotaped....
Survival benefits of post-operative systemic and radiation therapy in high-risk stage I endometrial cancer are uncertain.To compare recurrence patterns survival outcomes post-surgical treatment patients with to determine whether adjuvant significantly improves outcomes.High-risk was defined as either IB grade 3 endometrioid histology or myoinvasive non-endometrioid histology. Consecutive diagnosed between January 2000 December 2010 eight centers were included. Patients, disease,...