A5113690007- Phytochemical compounds biological activities
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Pancreatic and Hepatic Oncology Research
- Allergic Rhinitis and Sensitization
- Synthesis and bioactivity of alkaloids
- Dermatology and Skin Diseases
- Cell death mechanisms and regulation
- Bioactive Compounds and Antitumor Agents
- RNA modifications and cancer
- Chromatography in Natural Products
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Phytochemistry and Bioactive Compounds
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Ginger and Zingiberaceae research
- Cholesterol and Lipid Metabolism
- Phytochemistry and biological activity of medicinal plants
- Plant-based Medicinal Research
- Reproductive System and Pregnancy
- NF-κB Signaling Pathways
- Flavonoids in Medical Research
- Oral Health Pathology and Treatment
Shenzhen University
2018-2025
Shanghai University of Traditional Chinese Medicine
2021
Chinese University of Hong Kong
2012-2019
Guangzhou University of Chinese Medicine
2011-2014
Zero to Three
2012
The transcription factor Nrf2 regulates the basal and inducible expression of a battery cytoprotective genes. Whereas numerous Nrf2-inducing small molecules have been reported, very few chemical inhibitors identified to date. quassinoid brusatol has recently shown inhibit ameliorate chemoresistance in vitro vivo. Here, we show that provokes rapid transient depletion protein, through posttranscriptional mechanism, mouse Hepa-1c1c7 hepatoma cells. Importantly, also inhibits freshly isolated...
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that biological activities are intimately related to metabolites. In current investigation, we aimed comparatively explore effects tetrahydrocurcumin (THC), octahydrocurcumin (OHC), CUR, elucidate underlying action mechanisms on experimental mice...
Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in treatment dysenteric disorders (also known as ulcerative colitis(UC)). Due to its poor aqueous solubility, novel brusatol self-microemulsifying drug delivery system (BR-SMEDDS) nanoformulation with smaller size, higher negative zeta potential and content, excellent stability was developed. The appearance BR-SMEDDS remained clear transparent, transmission electron...
Pancreatic cancer is highly resistant to chemotherapeutic agents and known have a poor prognosis. The development of new therapeutic entities badly needed for this deadly malignancy. In study, we demonstrated the first time that brusatol, natural quassinoid isolated from Chinese herbal medicine named Bruceae Fructus, possessed potent cytotoxic effect against different pancreatic adenocarcinoma cell lines. Its anti-pancreatic was comparable first-line such as gemcitabine 5-fluorouracil, with...
Glioblastoma is one of the most common and lethal intracranial malignant, still lack ideal treatments. Kaempferol a major nutrient found in various edible plants, which has exhibited potential for treatment glioblastoma. However, specific anti-glioma mechanism kaempferol yet to be studied. Herein, we aim explore mechanisms underlying activity kaempferol. Our results demonstrated that suppresses glioma cell proliferation vitro inhibits tumor growth vivo . Moreover, raises ROS decreases...
Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities. However, the biologic mechanisms have not been fully explored. In this study, BD more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker effects GES-1 cells (non-tumorigenic). was shown to elicit apoptosis through inducing both intrinsic and extrinsic mitochondria-mediated caspase activations. Furthermore, BD-induced apoptotic were dependent...
Colorectal cancer (CRC) is a common and life‑threatening type of malignant cancer, which associated with high mortality rate. Cisplatin (CDDP) commonly used chemotherapy drug significant side effects. Brusatol (BR) one the principal chemical compounds isolated from Chinese herb Bruceae Fructus, has been reported to markedly inhibit proliferation numerous cell lines. The present study aimed investigate possible synergistic anticancer effects CDDP combined BR on CT‑26 cells, evaluate...
A simple and sensitive method was developed validated for profiling simultaneous quantitation of seven alkaloids (6‐hydroxy‐β‐carboline‐1‐carboxylic acid, β‐carboline‐1‐carboxylic β‐carboline‐1‐propanoic 3‐methylcanthin‐5,6‐dione, 5‐hydroxy‐4‐methoxycanthin‐6‐one, 1‐methoxycarbony‐β‐carboline, 4,5‐dimethoxycanthin‐6‐one) in P icrasma quassioide grown different locations by high‐performance liquid chromatography with photodiode array detection. The analysis conducted on a henomenex G emini C...
Bruceine D is one of the active components Brucea javanica (L.) Merr., which widely used to treat cancer in China. The aim present study was evaluate potential effect bruceine against non‑small‑cell lung (NSCLC) cells and delineate its underlying mechanisms. results indicated that treatment with markedly inhibited proliferation wild‑type NSCLC epidermal growth factor receptor‑mutant a dose‑ time‑dependent manner, significantly decreased colony‑forming ability migration A549 cells. Hoechst...
Triple-negative breast cancer (TNBC) has been acknowledged as an aggressive disease with worst prognosis, which requires endeavor to develop novel therapeutic agents. Bruceae fructus oil (BO), a vegetable derived from the fruit of Brucea javanica (L.) Merr., is approved marketable drug for treatment in China several decades. Despite that anti-breast activity quassinoids B. found, it was first time potential BO against TNBC revealed. Although had no cytotoxicity on cell lines vitro, oral...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant and lethal human cancers in world due to its high metastatic potential, patients with PDAC have a poor prognosis, yet quite little understood regarding underlying biological mechanisms capacity. Baicalein has dramatic anti-tumor function treatment different types cancer. However, therapeutic effects baicalein on action not been extensively understood. In order explore characteristic, molecular mechanisms, potential clinical...
Propose: Oxyberberine (OBB), one of the main metabolites berberine derived from intestinal and erythrocyte metabolism, exhibits appreciable anti-hyperuricemic activity. However, low water solubility poor plasma concentration–effect relationship OBB hamper its development utilization. Therefore, an OBB-hydroxypropyl-β-cyclodextrin (HP-β-CD) supersaturated drug delivery system (SDDS) was prepared characterized in this work. Methods: OBB-HP-β-CD SDDS using ultrasonic-solvent evaporation method...
Tumor-stromal interactions and stromal heterogeneity in the tumor microenvironment are critical factors that influence progression, metastasis, chemoresistance of pancreatic ductal adenocarcinoma (PDAC). Here, we used spatial transcriptome technology to profile gene expression landscape primary PDAC liver metastatic after bioactive black phosphorus nanomaterial (bioactive BP) treatment using a murine model (LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre mice). Bioinformatic biochemical analyses...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis earliest stage NAFLD, which characterized by an accumulation hepatic lipids. Patchouli oil (PO), isolated from well-known Chinese herb named Pogostemon cablin (Blanco) Benth. (Lamiaceae), inhibits lipid effectively. However, its potential ability for treatment NAFLD had not been reported before. Thus, objective this study was to...
Background:Brucea javanica (L.) Merr, has a long history to be an anti-dysentery medicine for thousand of years, which is commonly called "Ya-Dan-Zi" in Chinese. The common liquid preparation its seed, B. oil (BJO) exerts anti-inflammatory action gastrointestinal diseases and popularly used as antitumor adjuvant Asia. However, there no report that BJO the potential treat 5-Fluorouracil (5-FU)-induced chemotherapeutic intestinal mucosal injury (CIM). Aim study: To test hypothesis protection...
β-Patchoulene (β-PAE) is a tricyclic sesquiterpene isolated from patchouli oil. According to our previous study, β-PAE has anti-inflammatory activity in vivo; however, its response still remains unconfirmed vitro. Therefore, this study committed demonstrate the effect of on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. results, pre-treatment with significantly decreased protein and messenger RNA (mRNA) levels pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α),...