A5074171657- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Supramolecular Self-Assembly in Materials
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Veterinary Equine Medical Research
- Bone fractures and treatments
- Advanced X-ray and CT Imaging
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- Hip disorders and treatments
- Inflammatory mediators and NSAID effects
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Carbohydrate Chemistry and Synthesis
- Shoulder Injury and Treatment
- Photoacoustic and Ultrasonic Imaging
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
Navrachana University
2018-2024
Boston University
2017-2024
Maharaja Sayajirao University of Baroda
2023
Beth Israel Deaconess Medical Center
2021
Inserm
2011-2018
Bordeaux Population Health
2011-2018
Case Western Reserve University
2017
Université de Bordeaux
2011-2015
Régulations Naturelle et Artificielle
2013-2015
Galen University
2014
Mechanical loading regulates mesenchymal condensation–mediated endochondral bone regeneration.
Abstract The economic and societal impacts of nano-materials are enormous. However, releasing such materials in the environment could be detrimental to human health ecological biosphere. Here we demonstrate that gold quantum dots nanoparticles bio-accumulate into mucus coming from natural species as jellyfish. One strategy emerges this finding would take advantage these trapping properties remove contaminated water.
Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation clinically useful imaging tools. An optimized efficient large-scale synthesis a cationic iodinated contrast agent (CA4+) is described for articular cartilage. Contrast-enhanced CT (CECT) using CA4+ reveals significantly greater uptake in cartilage compared to similar anionic or nonionic agents, follows Donnan equilibrium theory. The CECT...
Nanoparticle biodistribution in vivo is an essential component to the success of nanoparticle-based drug delivery systems. Previous studies with fluorescently labeled expansile nanoparticles, or "eNPs", demonstrated a high specificity eNPs tumors that achieved through materials-based targeting strategy. However, fluorescent labeling techniques are primarily qualitative nature and gold-standard for quantitative evaluation radiolabeling. In this manuscript, we synthesize 14C-labeled...
A nucleotide–lipids family featuring the four natural nucleobases was explored through their self-assembly properties.
The construction of new nanotools is presented here using the example fluorescent semiconductor nanocrystals, quantum dots (QDs). In this study, implementation lipid oligonucleotide conjugate-functionalized (LON-QDs) realized in four steps: (i) synthesis conjugates (LONs), (ii) encapsulation QDs by nucleolipids and LONs, (iii) study duplex formation LON-QDs with complementary ON partners, (iv) cellular uptake LON-QD platform hybridization target ONs (microRNA miR-21).
Nucleic acid-based fluorinated derivatives, e.g., nucleosides or oligonucleotides connected to highly chains labeled with one more fluorine atoms, have been investigated recently due their high potential for biomedical applications. This review deals recent works on nucleoside and oligonucleotide fluorocarbon amphiphiles as well properties applications of fluorine-labeled analogues.
The growing use of nanomaterials and their associated risks necessitate the emergence efficient decontamination systems. main objective this study is to develop a new prototype based on artificial supramolecular hydrogel capable removing nanoparticle (NP) waste nanomaterial by-products from aqueous suspensions. We demonstrate high trapping efficacy low-molecular-weight gelators (LMWG) for very small particles (quantum dots (QDs), gold nanoparticles (AuNPs), TiO2 (TiO2-NPs), below 50 nm in...
Ferrocene-linked bis(nucleobase) (1a−c) and chimeric nucleobase (1d) conjugates have been synthesized from mono- bis(hydroxybutyl)ferrocene 6 via Mitsunobu reaction as the key step. X-ray crystallographic studies of ferrocene reveal two-dimensional supramolecular organizations backbones through self-assembled Watson−Crick reverse type pairs. Ferrocene−bis(thymine) conjugate self-assembles by pairing, while corresponding bis(uracil) alternating WC pairing. Such continuous assemblies are not...
X-ray crystallographic studies of methylene linked Ferrocene-bis(thymine/uracil) conjugates Fc(T:T)M and Fc(U:U)M reveal base dependent 2-D supramolecular assemblies generated via wobble self-pairing for bis-thymine reverse bis-uracil conjugates, differing in architecture from the corresponding butylene spacer
We report new glycosyl-nucleoside-lipid based liposomes decorated with sugar moieties. The GNL-liposomes feature a suitable glycosylated surface for their internalization into ADSC stem cells.
Objective To investigate the diffusion trajectory of a cationic contrast medium (CA4+) into equine articular cartilage, and to assess normal degenerative cartilage using contrast-enhanced computed tomography (CECT). Design In first experiment (Exp1), osteochondral specimens were serially imaged with CECT establish time constant reach equilibrium in healthy cartilage. separate (Exp2), defects created on femoral trochlea (defect joint) juvenile horse, while opposite joint was sham-operated...
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported chain glycerol-based GNLs. The second generation of GNFs free nucleobase here presents better...
Nanoparticle-based contrast agents, when used in concert with imaging modalities such as computed tomography (CT), enhance the visualization of tissues and boundary interfaces. However, ability to determine physiological state tissue via quantitative assessment biochemical or biomechanical properties remains elusive. We report synthesis characterization tantalum oxide (Ta2O5) nanoparticle (NP) agents for rapid, nondestructive, contrast-enhanced (CECT) assess both glycosaminoglycan (GAG)...
Lipid oligonucleotides (LONs) self-assemble into supramolecular structures. This property has an impact on the biological effects of oligonucleotide sequences.
Abstract Polymeric hindered amine light stabilizers (HALSs), in which the HALS functionality was attached to terminal isocyanate chain end of poly(styryl‐ co ‐styryl isocyanate), were synthesized by a two‐step process. First, cinnamoyl azide prepared and copolymerized with styrene free‐radical copolymerization method. low‐molecular‐weight high‐molecular‐weight 2,2,6,6‐tetramethyl‐4‐pipridinol‐ graft ‐poly(styryl‐ isocyanate) 4‐amino‐2,2,6,6‐tetramethyl piperidine‐ grafting The...
Hybrid nucleotide-lipids containing locked nucleic acid (LNA) show enhanced hybridization properties with complementary single strand RNAs compared to DNA lipid analogues. The LNA adenosine features unique binding a high affinity for poly-uridine and the entropically driven formation of stable complex (Kd ≈ 43 nM). Enhanced LNA-based lipids should be applicable development oligonucleotide (ON) delivery systems or as small molecule binders RNA novel therapeutic strategies.
Abstract Cationic contrast‐enhanced computed tomography (CECT) is a quantitative imaging technique that characterizes articular cartilage, though its efficacy in differentiating repair tissue from other disease states undetermined. We hypothesized cationic CECT attenuation will distinguish between reparative, degenerative, and healthy equine cartilage reflect biochemical, mechanical, histologic properties. Chondral defects were created vivo on femoropatellar joint surfaces. Within defects,...
Abstract A lack of understanding the mechanisms underlying osteoarthritis (OA) progression limits development effective long‐term treatments. Quantitatively tracking spatiotemporal patterns cartilage and bone degeneration is critical for assessment more appropriately targeted OA therapies. In this study, we use contrast‐enhanced micro‐computed tomography (μCT) to establish a timeline subchondral plate (SCP) changes in murine femur after destabilization medial meniscus (DMM). We performed DMM...