A5079065320- Pneumonia and Respiratory Infections
- Salmonella and Campylobacter epidemiology
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Bacterial Infections and Vaccines
- Vibrio bacteria research studies
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- Healthcare Systems and Reforms
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Child Nutrition and Water Access
- Hepatitis B Virus Studies
- Global Maternal and Child Health
MRC Unit the Gambia
2015-2022
Aga Khan University
2006-2014
Pneumococcal conjugate vaccines (PCVs) are used in many low-income countries but their impact on the incidence of pneumonia is unclear. The Gambia introduced PCV7 August, 2009, and PCV13 May, 2011. We aimed to measure introduction these incidence.We did population-based surveillance case-control studies. primary endpoint was WHO-defined radiological with pulmonary consolidation. Population-based for suspected children aged 2-59 months (minimum age 3 study) between May 12, 2008, Dec 31, 2015....
BackgroundThe Gambia introduced seven-valent pneumococcal conjugate vaccine (PCV7) in August 2009, followed by PCV13 May, 2011, using a schedule of three primary doses without booster dose or catch-up immunisation. We aimed to assess the long-term impact PCV on disease incidence.MethodsWe did 10 years population-based surveillance for invasive (IPD) and WHO defined radiological pneumonia with consolidation rural Gambia. The population included all Basse Health Demographic Surveillance System...
Introduction: Enteric fever remains a major public health problem in Asia. Planning appropriate preventive measures such as immunization requires clear understanding of disease burden. We conducted community-based surveillance for Salmonella Typhi infection children Karachi, Pakistan. Methodology: A de jure household census was at baseline the study setting to enumerate all individuals. health-care facility-based passive system used capture episodes lasting three or more 3 days 2 16 years...
SUMMARY We analysed the data from control group in a typhoid vaccine trial Karachi to assess differences individual-, household- and cluster-level characteristics for developing fever. The annual incidence of children aged 2–16 years arm was 151/100 000 population. After adjustment, risk lower with increasing age [risk ratio (RR) 0·89, 95% confidence interval (CI) 0·83–0·95], higher an increase population density (RR 1·13, CI 1·05–1·21) households using safe drinking-water source 0·63,...
ABSTRACT The geometric mean concentration (GMC) and the proportion maintaining a protective level (150 enzyme-linked immunosorbent assay (ELISA) units [ELU]/ml) 2 years following single dose of 25 μg injectable Vi capsular polysaccharide typhoid vaccine was measured against that control hepatitis A in children to 16 old cluster randomized trials Karachi Kolkata. GMC for group (1,428 ELU/ml) statistically significantly different from (86 after 6 weeks. total 117 (95.1%) 9 (7.5%) showed 4-fold...
To determine the safety and logistic feasibility of a mass immunization strategy outside local program in pediatric population urban squatter settlements Karachi, Pakistan.A cluster-randomized double blind preventive trial was launched August 2003 60 geographic clusters covering 21,059 children ages 2 to 16 years. After consent obtained from parents or guardians, eligible were immunized parenterally at vaccination posts each cluster with Vi polysaccharide hepatitis A vaccine. Safety,...
Background: In 1997, The Gambia became the first African country to introduce conjugate Haemophilus influenzae type b (Hib) vaccine with good disease control through 2010. Methods: Culture-based surveillance for invasive bacterial in eastern Gambia, specifically Basse Health and Demographic Surveillance System (BHDSS) area, was conducted from 12 May 2008 Fuladu West district September 2011 until 31 December 2013. 2011, Hib serology measured 5–34-year-olds. Results: all, 16,735 of 17,932...
Representative data describing serious infections in children aged ≥5 years and adults Africa are limited.We conducted population-based surveillance for pneumonia, meningitis, septicemia a demographic area The Gambia between 12 May 2008 31 December 2015. We used standardized criteria to identify, diagnose, investigate patients using conventional microbiology radiology.We enrolled 1638 of 1657 eligible investigated 1618. Suspected septicemia, or meningitis was diagnosed 1392, 135, 111...