Mihnea Zdrenghea
A5063120635- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Vitamin D Research Studies
- Immunodeficiency and Autoimmune Disorders
- Cardiac Valve Diseases and Treatments
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cardiac pacing and defibrillation studies
- Epigenetics and DNA Methylation
- Eosinophilic Disorders and Syndromes
- Viral-associated cancers and disorders
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Kruppel-like factors research
- Cardiovascular Effects of Exercise
- Respiratory viral infections research
- Hematopoietic Stem Cell Transplantation
Iuliu Hațieganu University of Medicine and Pharmacy
2016-2025
Institute of Oncology Prof. Dr. Ion Chiricuta
2016-2025
Spitalul Clinic Județean de Urgență Cluj-Napoca
1994-2024
University Hospital of Zurich
2024
University of Zurich
2024
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
2002-2023
Regeneron (United States)
2022
AstraZeneca (Brazil)
2022
Triangle
2022
Bristol-Myers Squibb (Switzerland)
2022
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study characterize course COVID-19 in and identify potential predictors outcome. Of 190 confirmed diagnosed between 28/03/2020 22/05/2020, 151 (79%) presented (need oxygen and/or intensive care admission). Severe was associated advanced...
Abstract Myeloproliferative neoplasms (MPNs) are uncommon in children/young adults. Here, we present data on unselected patients diagnosed before 25 years of age included from 38 centers 15 countries. Sequential were included. We identified 444 patients, with median follow-up 9.7 (0-47.8). Forty-nine (11.1%) had a history thrombosis at diagnosis, 49 new thrombotic events recorded (1.16% patient per year [pt/y]), perihepatic vein thromboses most frequent (47.6% venous events), and logistic...
Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient important pathogenesis investigated regulation IL-15 induction by rhinovirus human macrophages vitro, levels bronchoalveolar lavage (BAL) fluid BAL from asthmatic control subjects, related these to outcomes infection vivo. induced was replication-, NF-κB- α/β interferon-dependent. macrophage impaired asthmatics...
Respiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants. It also responsible for high morbidity and mortality the elderly. Programmed death ligands (PD-Ls) on antigen-presenting cells interact with receptors T to regulate immune responses. The programmed receptor-ligand 1/programmed receptor 1 (PD-L1-PD-1) pathway inhibitory chronic viral infections, but its role acute infections unclear. We hypothesized that bronchial epithelial cell (BEC) expression PD-Ls would...
Background and aims: Every year, in Europe, acute myeloid leukemia (AML) is diagnosed thousands of adults. For most subtypes AML, the backbone treatment was introduced nearly 40 years ago as a combination cytosine arabinoside with an anthracycline. This therapy still worldwide standard care. Two-thirds patients achieve complete remission, although them ultimately relapse. Since FLT3 mutation frequent, it serves key molecular target for tyrosine kinase inhibitors (TKIs) that inhibit kinase....
Introduction. The advent of Bruton’s tyrosine kinase (BTK) inhibitors brought about a paradigm shift in the management chronic lymphocytic leukemia (CLL), by offering well-tolerated chemotherapy-free approach. Here, we share experience with ibrutinib major Romanian regional cancer center. Methods. We screened patients treated for CLL our center over 6 years (2017- 2022) and included those who were either first line therapy or subsequent lines. Results. enrolled 61 patients, 40...
Abstract Essential thrombocythemia (ET) and polycythemia vera (PV) are rare in adolescent young adult (AYA). These conditions, similar to those older patients, linked with thrombotic complications the potential progression secondary myelofibrosis (sMF). This retrospective study of ET PV patients diagnosed before age 25 evaluated complication rates impact cytoreductive drugs on outcomes. Among 348 (278 ET, 70 PV) a median 20 years, events was 1.9 per 100 patient-years. Risk factors for...
The cytokine interleukin (IL)-15, major histocompatibility complex (MHC) class I molecules and MHC chain-related proteins (MIC) A B are involved in cellular immune responses to virus infections but their role respiratory syncytial (RSV) infection has not been studied. We aimed determine how RSV modulates IL-15 production, MICA expression epithelial cells, the molecular pathways implicated virus-induced production interferon (IFN)-γ alters RSV-induced expression. infected cell lines (A549...
Polycythaemia vera ( PV ), essential thrombocythaemia ET ) and primary myelofibrosis PMF represent typical myeloproliferative neoplasms MPN usually characterized by specific somatic driver mutations JAK 2 V617F, CALR MPL ). 46/1 haplotype telomerase reverse transcriptase gene TERT rs2736100 A>C single nucleotide polymorphism SNP could a large fraction of the genetic predisposition seen in . The rs10974944 C>G , tagging haplotype, were genotyped 529 patients with known status, 433...
BackgroundMepolizumab, an anti-interleukin-5 (IL-5) antibody, reduces disease flares in patients with hypereosinophilic syndrome (HES). Factors predicting treatment response are unknown.ObjectiveTo assess mepolizumab efficacy by baseline blood eosinophil count (BEC) and serum IL-5 level HES.MethodsThis post hoc analysis used data from the phase III study assessing HES (NCT02836496). Patients 12 years old or older, for 6 more months, 2 previous year, BEC ≥1,000 cells/μL at screening were...
Objective. Hyperuricaemia is necessary for gout. High urate concentrations have been linked to inflammation in mononuclear cells. Here, we explore the role of suppressor cytokine signaling 3 (SOCS3) urate-induced inflammation. Methods. Peripheral blood cells (PBMCs) from gout patients, hyperuricemic and normouricemic individuals were cultured 24h with varying soluble urate, followed by restimulation lipopolysaccharides (LPS) ± monosodium (MSU) crystals. Transcriptomic profiling was performed...
Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during preconditioning period and predominantly post-intervention, exemplified by occurrence graft-versus-host disease (GVHD). Risk stratification prior to symptom manifestation, along precise diagnosis prognosis, relies heavily on clinical features. A critical imperative is development tools capable early identification effective...