A5000211439- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Psychosomatic Disorders and Their Treatments
- S100 Proteins and Annexins
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Nitric Oxide and Endothelin Effects
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Colorado Anschutz Medical Campus
2024
National Institutes of Health
2021-2022
National Institute of Allergy and Infectious Diseases
2021-2022
Background: A substantial proportion of persons who develop COVID-19 report persistent symptoms after acute illness. Various pathophysiologic mechanisms have been implicated in the pathogenesis postacute sequelae SARS-CoV-2 infection (PASC). Objective: To characterize medical and recovery from a cohort disease survivors controls. Design: Cohort study. (ClinicalTrials.gov: NCT04411147) Setting: National Institutes Health Clinical Center, Bethesda, Maryland. Participants: Self-referred adults...
Messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective at inducing protective immunity. However, weak antibody responses seen in some individuals, and cellular correlates of immunity remain poorly defined, especially for B cells. Here we used unbiased approaches to longitudinally dissect primary antibody, plasmablast, memory cell (MBC) the two-dose mRNA-1273 vaccine SARS-CoV-2-naive adults. Coordinated immunoglobulin A (IgA)...
Acute respiratory distress syndrome (ARDS) is a serious illness accounting for 10% of ICU admissions and high mortality 31-45% with paucity pharmacologic treatment options. Dysregulated inflammation oxidative stress are hallmark features ARDS. We previously showed that transgenic mice expressing naturally occurring polymorphism the antioxidant enzyme extracellular superoxide dismutase (EC-SOD), protected against
Abstract SARS-CoV-2 mRNA vaccines are highly effective, although weak antibody responses seen in some individuals with correlates of immunity that remain poorly understood. Here we longitudinally dissected antibody, plasmablast, and memory B cell (MBC) to the two-dose Moderna vaccine SARS-CoV-2-uninfected adults. Robust, coordinated IgA IgG were preceded by bursts spike-specific plasmablasts after both doses, but earlier more intensely dose two. Distinct antigen-specific MBC populations also...
We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host responses in people with HIV receiving antiretroviral therapy. Our data suggest that SARS-CoV-2 vaccine is not likely to replenish persistent nor provide an immunologic environment facilitate active expression/replication.
SARS-CoV-2 mRNA booster vaccines provide protection from severe disease, eliciting strong immunity that is further boosted by previous infection. However, it unclear whether these immune responses are affected the interval between infection and vaccination. Over a two-month period, we evaluated antibody B-cell to third dose vaccine in 66 individuals with different histories. Uninfected post-boost but not previously infected mounted robust ancestral variant spike-binding neutralizing...