A5089339024- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Congenital Heart Disease Studies
- Chronic Lymphocytic Leukemia Research
- Connective tissue disorders research
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Infective Endocarditis Diagnosis and Management
- Phonocardiography and Auscultation Techniques
- Ultrasound in Clinical Applications
- Blood groups and transfusion
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Platelet Disorders and Treatments
- Congenital heart defects research
- Medical and Biological Ozone Research
- Cardiovascular and Diving-Related Complications
- Blood donation and transfusion practices
- Liver Disease and Transplantation
- Pericarditis and Cardiac Tamponade
- Hematological disorders and diagnostics
Delhi Technological University
2024
Indraprastha Apollo Hospitals
2007-2024
Weatherford College
2022
Medanta The Medicity
2017
Apollo Hospitals
2012
Apollo Hospitals
2011
Topiwala National Medical College & BYL Nair Charitable Hospital
2008
Fortis Escorts Heart Institute
2004-2006
Guy's Hospital
1992-1997
University Hospital Lewisham
1992
To define the phenotype of patients with benign joint hypermobility syndrome (BJHS), we studied 58 consecutive (mean age 37 yr) presenting to a rheumatology clinic and 30 controls. Patients underwent rheumatological ophthalmic examination, scoring, echocardiography, measurement bone mineral density (BMD), skin thickness, elasticity light transmissibility. The median score was 5/9 Beighton 31/56 Contompasis. Eighteen (31%) complained significant arthralgia. Six (10%) two (7%) controls had...
Cardiac abnormalities such as mitral valve prolapse (MVP) are reported to be common features of the Ehlers Danlos syndrome (EDS), and it has been suggested that majority patients with type IV EDS will have cardiac involvement vascular aneurysms. However, evidence for lesions is inconsistent often based on early clinical studies using mainly M-mode echo. We studied 33 (six male, 27 female; median age 35 yr) (30 I, II or III, three IV) 30 age- sex-matched controls. The study assessed skin...
Protruding atheromas of thoracic aorta have been identified as a source systemic emboli and major cause stroke following cardiac surgery. This prospective study used transesophageal echocardiography (TEE) to identify atherosclerosis intraoperatively. The influence risk factors was studied. Finally the impact modifying surgical technique on outcome evaluated.Seven-hundred ninety-two patients undergoing coronary artery bypass grafting (CABG) were evaluated with TEE. Depending location extent...
Wild coffee species are the reservoirs of genetic diversity and could play a critical role in improvement coffee. However, conservation assessment wild has been largely neglected. In present study, DNA barcoding approaches were employed to assess phylogenetic relationships between five indigenous from India compared with two cultivated, four African origin. The efficacy three loci namely matK,rbcL, trnL-trnF was investigated using PCR amplification sequence characterization. intergenic...
Women with high-risk pregnancies are offered prenatal diagnosis through amniocentesis for cytogenetic analysis of fetal cells. The aim this study was to evaluate the effectiveness rapid fluorescence in situ hybridization (FISH) technique detecting numerical aberrations chromosomes 13, 21, 18, X and Y an Indian scenario.A total 163 samples were received a FISH and/or full karyotype from pregnancies. In 116 both conventional culture techniques getting G-banding applied conjunction test using...
Lung cancer ranks among the top causes of mortality worldwide. Non-small cell lung (NSCLC) accounts for majority cases. Advances in genomics have identified potential biomarkers to predict therapeutic strategies cancer. Despite availability targeted drugs such as tyrosine kinase inhibitors, a substantial proportion patients still experience problems drug resistance. Mutations genes like epidermal growth factor receptor (EGFR) and EML4ALK already been established with altered clinical...
Grasspeas pose challenges in obtaining high-quality DNA due to their seed and leaves’ high protein, phenols, secondary metabolites, neurotoxins. This study investigated the faced by CTAB method isolation, subsequent enhancements quality storage with a modified approach using triton, PVP, salt TE sodium acetate extract genomic from grasspea.
Birth defects are structural or functional abnormalities present at birth that can cause physical mental disability in new borns. be due to genetic problems caused by mutation one more genes, chromosome aneuploidy environmental factors women exposed during pregnancy. The aim of the study was evaluate effectiveness Rapid-Fluorescence-in-Situ-Hybridization (Rapid-FISH) technique detecting numerical aberrations 13, 21, 18, X and Y amniocyte nuclei from amniotic fluid for avoiding performed on...
e20001 Background: Chromosome abnormalities of leukemia cells have important prognostic significance in childhood acute lymphoblastic (ALL). The prevalence various chromosomal shows geographical and racial variation. There is limited data from the Indian sub- continent. Methods: Bone marrow samples 89 children between age group 1-18 diagnosed with ALL were analyzed for conventional G-banding techniques interphase fluorescence situ hybridization (FISH) using locus specific probes to detect...
In India the incidence of breast cancer has increased in urban population with 1 every 22 women diagnosed cancer. It is important to know Her2/neu gene status for a better prognostication these patients. The aim study was compare efficacy fluorescent situ hybridisation (FISH) and immunohistochemistry (IHC) determining alteration carcinoma. A total 188 histologically proven carcinoma cases between years 2007–2011 were retrospectively analysed on paraffin tissue sections by both IHC & FISH...
We report a case of an elderly 68-year-old male who presented in our hospital with chief complaints petechial rashes and ecchymosis over extremities bleeding from the oral cavity since 3-4 days prior to hospitalization. He saw physician before coming received one dose IV methylprednisolone wysolone. had come for further management. Bone marrow karyotyping was done chromosomal analysis revealed two cell lines. Eighty percent cells analyzed apparently normal karyotype. However, 20% total 184...
Introduction: Congenital heart disease is one of the common fetal anomalies. Incidence CHD about 12 per 1000 live births. The causes are chromosomal (5 to 6%), single gene defects (3 5%), or environmental factors (2%). Risk increases if mother sibling had up 10%. In 85 90% cases, there no identifiable cause and generally considered be caused by multifactorial inheritance. Material methods: We report a case phenotypically normal 28 year old woman who overall three consecutive aberrant...