A5101790423- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
- Photosynthetic Processes and Mechanisms
- Herpesvirus Infections and Treatments
- Microbial Metabolites in Food Biotechnology
- Cytomegalovirus and herpesvirus research
- Plant Stress Responses and Tolerance
- HIV Research and Treatment
- Enzyme Production and Characterization
- Mycotoxins in Agriculture and Food
- Allelopathy and phytotoxic interactions
- Agricultural Science and Fertilization
- Phytase and its Applications
- Rice Cultivation and Yield Improvement
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Lipid metabolism and biosynthesis
- Virus-based gene therapy research
- Endoplasmic Reticulum Stress and Disease
- Plant responses to elevated CO2
- interferon and immune responses
Kurukshetra University
2012-2024
All India Institute of Medical Sciences
2014-2023
Government Medical College
2014-2022
Guru Gobind Singh Medical College and Hospital
2022
University of Florida
2015-2018
Florida College
2015-2018
Narendra Dev University of Agriculture and Technology
2017
Chaudhary Charan Singh Haryana Agricultural University
1993-2014
Agriculture and Agri-Food Canada
1977-2011
Rain Forest Research Institute
2003-2008
Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, (1998) Proc. Natl. Acad. Sci. USA 95, 14470–14475]. By using high-density cDNA microarrays, we show that HCMV-regulated gene profile in fibroblasts does not differ substantially from response generated by IFN. Furthermore, identified specific viral component triggering this as envelope glycoprotein B (gB)....
Previous studies have shown that human cytomegalovirus (CMV) is a potent elicitor of interferon-stimulated gene (ISG) expression. Induction the interferon pathway does not require replication-competent virus, and envelope glycoprotein B (gB) from CMV viral structural component can directly induce transcription ISGs. Here we extend these earlier findings by defining consequences inducing pathway. We found cells respond to or soluble gB establishing functional antiviral state within cell types...
Despite the tremendous economic impact of cereal crop pathogens such as fungus Fusarium graminearum, development strategies for enhanced protection is hampered by complex host genetics and difficulties in performing high-throughput analyses. To bypass these challenges, we have developed an assay which interaction between F. graminearum model plant Arabidopsis thaliana monitored liquid media 96-well plates. In this assay, fungal infection associated with dark lesion-like spots on cotyledons...
Abstract Cytochrome f was purified from spinach grana membranes with a final yield of 42%. Using technology disc gel electrophoresis and without nonionic detergent, it found that the cytochrome intrinsically hydrophobic existed as soluble aggregates at pH 8 which could be disaggregated by 0.1% detergent to single, stable, electrophoretic species. Disc non-ionic indispensable both in designing monitoring purification procedure served preparative chromatographic step. The moved single species...
The contributions of phenotypic plasticity to photosynthetic performance in winter (cv Musketeer, cv Norstar) and spring SR4A, Katepwa) rye (Secale cereale) wheat (Triticum aestivum) cultivars grown at either 20°C [non-acclimated (NA)] or 5°C [cold acclimated (CA)] were assessed. 22-40% increase light-saturated rates CO₂ assimilation CA vs NA cereals accounted for by as indicated the dwarf phenotype increased specific leaf weight. However, could not account (1) differential temperature...
The effect of growth at 5 degrees C on the trans-Delta(3)-hexadecenoic acid content phosphatidyl(d)glycerol was examined in a total eight cultivars rye (Secale cereale L.) and what (Triticum aestivum varying freezing tolerance. In these monocots, low temperature caused decreases between 0 74% with concomitant increases palmitic phosphatidyl(d)glycerol. These trends were observed for whole leaf extracts as well isolated thylakoids. temperature-induced decrease shown to be linear function...
Proteases are ubiquitous to all the living organisms. Their involvement in life cycle of various disease causing organisms has led them become a potential target for developing therapeutic agents against life-threatening diseases such as bacterial infection, cancer, malaria and AIDS. This review is mainly focused on applications microbial proteases serrapeptase, serrazime, lysostaphin, L-asparaginase, L-glutaminase, streptokinase, streptokinase-streptodornase xiaflex. These enzymes being...
ABSTRACT We previously reported that an amino acid substitution, Y704A, near the 2-fold interface of adeno-associated virus (AAV) was defective for transcription packaged genome (M. Salganik, F. Aydemir, H. J. Nam, R. McKenna, M. Agbandje-McKenna, and N. Muzyczka, J Virol 88:1071–1079, 2013, doi: http://dx.doi.org/10.1128/JVI.02093-13 ). In this report, we have characterized defect in 6 additional capsid mutants located a region ∼30 Å diameter on surface AAV type 2 (AAV2) interface. These...
Parthenium hysterophorus is an aggressive weed being invasive with allelopathic effect, it poses a serious threat to the environment and biodiversity.It adversely affects grazing animals human beings, which directly or indirectly comes in contact this weed.All ways control are not fully successful.However, recent reports suggest its medicinal uses as antidiabetic, antioxidant, antitumor antimalarial can be explored for use after scientific trials.It also rich source of minerals like N, P, K,...
Outbreak of COVID-19 by SARS-CoV-2 infection caused severe acute respiratory syndrome that has been declared a public health emergency international concern. To control infections, there is urgent need to develop an effective therapeutic strategy. viral spike glycoprotein and proteases play major role in entry mediating virus replication spread thus can serve as potential antiviral drug target. Being highly specific, efficacious safe, peptides hold their place therapeutics. In present study,...
Keeping in view the immense biological importance of fluoroquinolones and aminobenzothiazoles as antimicrobials search for better antibacterial agents, design synthesis new fluoroquinolone derivatives having substituted piperazine rings at C-7 position are described present communication. The synthesized compounds were characterized by suitable spectroscopic methods. Most (4a–l) demonstrated high vitro activity with some exhibiting more potent activities against Gram-positive organisms than...
The herpes simplex virus (HSV) type 1 strict late (gamma) UL38 promoter contains three cis-acting transcriptional elements: a TATA box, specific initiator element, and the downstream activation sequence (DAS). DAS is located between positions +20 +33 within 5' untranslated leader region strongly influences transcript levels during productive infection. In this communication, we further characterize investigate its mechanism of action. function has spacing requirement, an essential 6-bp core...