A5050383391- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Chemokine receptors and signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salivary Gland Tumors Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Vector-borne infectious diseases
- Viral-associated cancers and disorders
- Hematological disorders and diagnostics
- Bone and Joint Diseases
- T-cell and Retrovirus Studies
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations and Hemangiomas
Mito Saiseikai General Hospital
2024
University of Tsukuba Hospital
2019-2024
University of Tsukuba
2018-2023
Roche (United States)
2019
Tsuchiura Kyodo General Hospital
2016
Abstract Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function TET2 an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val mutant on Tet2-null background succumbed to AITL-like lymphomas due deregulated receptor (TCR) signaling. Using these mice investigate therapeutics for AITL, we found that dasatinib, multikinase inhibitor prolonged their survival through inhibition...
We here describe a case involving 67-yearold female patient who was referred to our hospital due severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 104/μL), and mediastinal shadow with calcification noted on X-ray. On admission, an anterior tumor detected, bone marrow biopsy revealed few megakaryocytes severely reduced numbers of erythroid cells. The diagnosis thymoma pure red cell aplasia (PRCA) acquired amegakaryocytic (AAMT). Day 8 the received immunosuppressive...
Chronic active Epstein-Barr virus infection (CAEBV) is critical owing to lethal complications such as hemophagocytic lymphohistiocytosis (HLH), multiple organ failure, and malignant lymphoma. Here we present two cases of CAEBV who developed rapid life-threatening disease progression after cytotoxic chemotherapy. Case 1: In a 34-year-old male, recurred 4-month remission obtained by initial therapy with etoposide, cyclosporine, prednisolone. Accordingly, cord blood transplantation was planned....
Objective Graft failure (GF) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). A standardized conditioning regimen and an appropriate graft source salvage HSCT for GF have not yet been established. Some case series shown good recoveries after using short-term reduced-intensity preparative consisting fludarabine (30-90 mg/m2), cyclophosphamide (2 g/m2), total-body irradiation Gy). However, the dose has varied in these reports based on clinical condition...
症例は75歳男性，4年前に肺腺癌（ⅡB期）に対し右下葉の摘出術を受け，術後カルボプラチン+ペメトレキセドを4コース施行した。その後，咳漱，労作時呼吸苦が出現増悪した。術前の胸部単純CTにて両下肺胸膜直下にスリガラス陰影を認めていたが，その後の胸部CTにて蜂巣肺，牽引性気管支拡張など両肺下葉末梢優位に陰影の増悪を認めた。特発性肺線維症を疑いプレドニゾロン（PSL），クラリスロマイシン（CAM），ピルフェニドンを投与するも改善に乏しく，今回PaO2 56mgHgと低酸素血症を認め，入院となった。問診にて30歳時より養鶏業に従事し，入院時は３,000羽の軍鶏を飼育していることがわかり，鳥関連過敏性肺炎を疑い，血清PDE（Pigeon dropping extracts）検査を施行した。PDE IgG 0.697，PDE IgA 0.445と高値を示し，慢性鳥飼病と診断した.画像からは特発性肺線維症との鑑別が困難であったが，問診とPDEが診断に有用であった。
<div>Abstract<p>Recurrent hotspot (p.Gly17Val) mutations in <i>RHOA</i> encoding a small GTPase, together with loss-of-function <i>TET2</i> an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val RHOA mutant on <i>Tet2</i>-null background succumbed to AITL-like lymphomas due deregulated receptor (TCR) signaling. Using these mice investigate therapeutics for AITL, we found that...
<p>Supplemental methods, results, figures, and tables.</p>
<p>Supplemental methods, results, figures, and tables.</p>
Background: Lipid metabolism plays an essential role in regulating stem and cancer cell function. The enzyme ELOVL6 converts C16 saturated monounsaturated fatty acids (FAs) to C18 species, the most important step for de novo synthesis of endogenous long chain FAs. Variations carbon length or degree desaturation FA greatly contribute lipid diversity. However, whether diversity significantly regulates hematopoietic biology remains unknown. Aims: To clarify how changes composition by Elovl6...
<div>Abstract<p>Recurrent hotspot (p.Gly17Val) mutations in <i>RHOA</i> encoding a small GTPase, together with loss-of-function <i>TET2</i> an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val RHOA mutant on <i>Tet2</i>-null background succumbed to AITL-like lymphomas due deregulated receptor (TCR) signaling. Using these mice investigate therapeutics for AITL, we found that...
Background: Angioimmunoblastic T‐cell lymphoma (AITL) is an intractable lymphoma. The recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with the loss‐of‐function TET2 epigenetic regulator, are genetic hallmark AITL. We previously identified that p. Gly17Val mutant hyperactivates receptor (TCR) signaling through direct binding to VAV1, component of TCR pathway. VAV1 were also found ‐negative AITL cases. phosphorylation induced by or its own amino acid changes...