A5031679877- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Coronary Interventions and Diagnostics
- Diet, Metabolism, and Disease
- Lanthanide and Transition Metal Complexes
- Folate and B Vitamins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes and associated disorders
- Cardiovascular Health and Risk Factors
- Advanced materials and composites
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Aluminum Alloys Composites Properties
Australian and New Zealand Intensive Care Society
2021
South Australian Health and Medical Research Institute
2014-2019
The University of Adelaide
2003-2018
Cleveland Clinic
2009-2018
Government of Western Australia Department of Health
2018
Wake Forest University
2008-2009
National Institutes of Health
2009
National Institute of Environmental Health Sciences
2009
United States Department of Health and Human Services
2009
University of Pennsylvania
2003-2006
Background— Stearoyl-coenzyme A desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose present study was to investigate role SCD1 in lipoprotein metabolism and atherosclerosis progression. Methods Results— Antisense oligonucleotides were used inhibit mouse model hyperlipidemia (LDLr −/− Apob 100/100 ). In agreement with previous reports, inhibition protected against diet-induced obesity, insulin resistance, hepatic steatosis. Unexpectedly, however, strongly...
Objectives— Cholesterol efflux is achieved by several mechanisms. This study examines contributions of these pathways to human serum. Methods and Results— Human fibroblasts were stably transfected with SR-BI while ABCA1 was upregulated. Quantitation cholesterol serum demonstrated that there from cells without either protein. Expression produced a small increase in efflux, whereas expression had dramatic impact. To quantitate contribution, pretreated Probucol BLT-1 to, respectively, inhibit...
CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol. Infusion of 3 mg/kg exhibited a potentially favorable effect on plaque burden in the CHI-SQUARE (Can HDL Infusions Significantly Quicken Atherosclerosis Regression) study. Since baseline atheroma has been shown as determinant for efficacy infusions, degree might influence CER-001.CHI-SQUARE compared 6 weekly infusions (3, and 12 mg/kg) vs. placebo coronary atherosclerosis 369...
Background— Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. We have previously reported that inhibition SCD1 in hyperlipidemic mice fed saturated fatty acid (SFA)-enriched diet prevented development the metabolic syndrome, yet surprisingly promoted severe atherosclerosis. In this study we tested whether dietary fish oil supplementation could prevent accelerated atherosclerosis caused by inhibition. Methods Results— LDLr −/− , ApoB 100/100 were...
Hepatic lipase (HL) and endothelial (EL) are both members of the triglyceride gene family. HL hydrolyzes phospholipids triglycerides in triglyceride-rich lipoproteins high-density (HDL). EL HDL has low activity. The aim this study was to determine if hydrolyze different whether phospholipid composition regulates interaction with particle surface. Spherical, reconstituted (rHDL) containing either 1-palmitoyl-2-oleoylphosphatidylcholine (POPC), 1-palmitoyl-2-linoleoylphosphatidylcholine...
Objectives Obesity is an independent risk factor for cardiovascular disease. Reverse cholesterol transport (RCT) important cardioprotective mechanism. This study aimed to investigate RCT changes in a murine model of obesity. Methods Ob/ob and control mice were injected with [3H]-cholesterol-labelled macrophages accumulation quantified after 48 h. Ex vivo, efflux uptake determined hepatic adipose tissues. Results had more labelled their plasma (86%, p<0.001), suggesting impaired RCT....
Background: Although high-density lipoprotein (HDL) has atheroprotective properties, the association of HDL functionality with coronary plaques remains unclear. Methods: We investigated between HDL-mediated cholesterol efflux capacity (CEC) and lipid burden in 74 patients who underwent near-infrared spectroscopy (NIRS) imaging for acute syndrome (ACS) or stable ischemic symptoms. measured baseline CEC, distinguishing specific pathways, stratified according to their median CEC values....
Abstract Nitric oxide (NO) is a key regulator of endothelial cell and vascular function. The direct measurement NO challenging due to its short half-life, as such surrogate measurements are typically used approximate relative concentrations. Here we demonstrate that ruthenium-based [Ru(bpy) 2 (dabpy)] 2+ potent sensor for in irreversible, NO-bound active form, (T-bpy)] . Using spectrophotometry established the sensor’s ability detect measure soluble concentration-dependent manner cell-free...
Purpose Acute kidney injury (AKI) is a significant cause of morbidity and mortality post cardiac surgery sometimes requiring intermittent hemodialysis (IHD) or continuous veno-venous hemofiltration (CVVH). Previous studies included only procedures utilizing cardiopulmonary bypass (CPB). We reviewed CPB non-CPB patients who developed AKI required CVVH versus no CVVH. Materials Methods 141 undergoing adult AKI. 70 (group1) 71 did not (group2). compared 30 day mortality, renal recovery,...