A5091785969- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Global Public Health Policies and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Chronic Disease Management Strategies
- Chronic Kidney Disease and Diabetes
- Antioxidant Activity and Oxidative Stress
- Child Nutrition and Water Access
- Agriculture Sustainability and Environmental Impact
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- NF-κB Signaling Pathways
- Nutritional Studies and Diet
- Acute Myocardial Infarction Research
- Pharmaceutical studies and practices
- Atherosclerosis and Cardiovascular Diseases
- HIV/AIDS Impact and Responses
- Immune Response and Inflammation
- Animal testing and alternatives
The University of Melbourne
2014-2020
Baker Heart and Diabetes Institute
2009-2018
University of South Australia
2014
Identification of individuals who are at risk suffering from acute coronary syndromes (ACS) may allow to introduce preventative measures. We aimed identify ACS-related urinary peptides, that combined as a pattern can be used prognostic biomarker. Proteomic data 252 enrolled in four prospective studies Australia, Europe and North America were analyzed. 126 these had suffered ACS within period up 5 years post urine sampling (cases). analysis 84 cases matched controls resulted the discovery 75...
Background: Historically, sub-Saharan Africa has reported low levels of atherosclerotic cardiovascular disease (CVD).However as these populations undergo epidemiological transition, this may change.Methods: This was an observational cohort study performed at Chris Hani Baragwanath Hospital in Soweto, South Africa.As part the Heart Soweto study, a clinical registry captured detailed data on all de novo cases structural and functional heart presenting to Cardiology unit during period 2006...
OBJECTIVE Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-κB (NF-κB) and c-Jun NH2-terminal kinase (JNK) pathways—two pathways proposed as link CLAIS resistance. RESEARCH DESIGN AND METHODS Adiposity (dual-energy X-ray absorptiometry), waist-to-hip ratio (WHR), sensitivity (M, hyperinsulinemic-euglycemic clamp) were measured 22 healthy nondiabetic...
Abstract Glomerular hyperfiltration has been associated with obesity, insulin resistance, and systolic blood pressure (SBP). However, previous studies are limited by confounders such as pre-existing diabetes or hypertension, have used indirect measures of adiposity sensitivity (IS). Therefore, we examined the relationship between estimated glomerular filtration rate (eGFR) IS measured hyperinsulinaemic euglycaemic clamp in a healthy population on no medications. We performed oral glucose...
One of the more notable public health debates in recent times relates to purported association between ubiquitous environmental chemical bisphenol-A (BPA) and a host chronic diseases. The past 5 years have seen rapid increase evidence linking BPA obesity, diabetes, cardiovascular disease human, population-based epidemiological studies. However, 2 reports (1, 2) JCEM, while both showing modest associations (measured urine) disease, achieved little definitively addressing controversy. Shankar...
High levels of circulating advanced glycation end products (AGEs) can initiate chronic low-grade activation the immune system (CLAIS) with each these factors independently associated cardiovascular (CV) morbidity and mortality. Therefore, our objective was to characterize relationship between serum AGEs, CLAIS other risk for CV disease in normotensive non-diabetic individuals.We measured body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, lipid glucose profile 44 volunteers (17...
In experimental studies, moderate to high concentrations of sCD14 (serum cluster differentiation 14 protein) prevent lipopolysaccharide (LPS)-induced systemic inflammation, while low may promote inflammation. Given that metabolic endotoxemia is thought initiate high-fat diet-induced insulin resistance, we explored the association between and sensitivity in humans.Healthy non-obese (n = 12, BMI 26 ± 5y), obese 11, 33.45 3.2) morbidly participants 38, 45 7) underwent measurement body...
Objectives To investigate if urban Africans displayed lower levels of atheroprotective high-density lipoprotein cholesterol (HDLC) when presenting with communicable versus non-communicable forms heart disease (HD) as both acute infection and chronic inflammation reduce HDLC levels. Design Hospital registry 5328 de novo cases HD over a 3-year period. Setting Cardiology Unit, Baragwanath in Soweto, South Africa. Participants A total 1199 patients African descent (59% women; 57.0±13.4 years)...
Abstract Objective: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators diet quality, antioxidants, associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants risk among Aboriginal people in Australia. Design: As part a community-driven promotion programme, we conducted cross-sectional including health-behaviour questionnaire, markers (anthropometric,...