A5056900333- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Fetal and Pediatric Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Muscle activation and electromyography studies
- Technology and Security Systems
- Education and Critical Thinking Development
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
- Ergonomics and Musculoskeletal Disorders
- Acute Ischemic Stroke Management
- Cancer, Hypoxia, and Metabolism
- Cerebral Venous Sinus Thrombosis
- Migraine and Headache Studies
- Traumatic Brain Injury and Neurovascular Disturbances
Washington University in St. Louis
2014-2023
Union Hospital
2013-2021
Jilin University
2014-2021
Singapore Bioimaging Consortium
2013-2021
Agency for Science, Technology and Research
2015-2021
Affiliated Hospital of Nantong University
2020
Nantong University
2020
Second Affiliated Hospital of Nantong University
2020
Huaqiao University
2020
Xiamen University
2020
Repetitive transcranial magnetic stimulation (rTMS) has demonstrated antidepressant efficacy but limited evidence in depression associated with traumatic brain injury (TBI). Here, we investigate the use of rTMS targeted individualized resting-state network mapping (RSNM) dorsal attention (DAN) and default mode (DMN) subjects treatment-resistant concussive or moderate TBI. The planned sample size was 50 first interim analysis at 20, only 15 were enrolled before study terminated for logistical...
White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 BACHD models HD. Using diffusion tensor magnetic resonance imaging (DT-MRI), demonstrate that microstructural WM abnormalities occur from an age mice. Similarly, electron microscopy analysis myelinated fibres corpus callosum indicated myelin...
Abstract Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention chronic subcortical patients with unilateral upper limb disability. Nineteen were randomized into sham-tDCS groups. Diffusion perfusion MRI, magnetic to study structural connectivity, cerebral blood flow (CBF),...
Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 10 mg/kg), novel immunomodulatory agent shown to be protective number neuroinflammatory conditions, YAC128 mouse model HD. Treatment with 6 months rescued atrophy striatum, certain cortical regions, corpus callosum HD mice. Diffusion tensor imaging showed that white matter microstructural abnormalities...
Background. Recent work has shown that resting-state functional connectivity (rsFC) between homotopic, motor-related brain regions is associated with upper-extremity control early after stroke. Objectives. This study examined various patterns of rsFC in chronic stroke, a time at which extensive neural reorganization occurred. Associations homotopic somatomotor and clinical measures, representing separate domains function, were determined. Methods. A total 19 persons ≥6 months poststroke...
Abstract Stroke leads to both regional brain functional disruptions and network reorganization. However, how networks reconfigure as task demand increases in stroke patients whether such reorganization at baseline would facilitate post-stroke motor recovery are largely unknown. To address this gap, connectivity (FC) were examined rest tasks eighteen chronic subcortical eleven age-matched healthy controls. underwent a 2-week intervention using imagery-assisted computer interface-based...
The inability of structural MRI to accurately measure tumor response therapy complicates care management for patients with gliomas. purpose this study was assess the potential several noninvasive functional and molecular biomarkers assessment glioma radiotherapy.Fourteen U87 tumor-bearing rats were irradiated using a small-animal radiation research platform (40 or 20 Gy), 6 used as controls. performed on 4.7 T animal scanner, preradiation treatment, well at 3, 6, 9, 14 days postradiation....
The subjective cognitive decline (SCD) may last for decades priors to the onset of dementia, and has been proposed as a risk population development amnestic mild impairment (aMCI) Alzheimer's disease (AD). Disruptions functional connectivity (FC) causal (CC) in salience network (SN) are generally perceived prominent hallmarks preclinical AD. Nevertheless, alterations anterior SN (aSN) posterior (pSN) remain unclear. Here, we hypothesized that both FC CC subnetworks, comprising aSN pSN, were...
Abstract Comparison of high angular resolution diffusion imaging (HARDI) measurements between subjects or timepoints for the same subject are facilitated by spatial normalization. In this work an algorithm was developed to transform fiber orientation distribution (FOD) function, based on HARDI data, taking into account not only translation, but also rotation, scaling, and shearing effects transformation. The tested using simulated data intrasubject intersubject normalization in vivo human...
To investigate white matter (WM) plasticity induced by intensive upper limb (UL) task specific training (TST) in chronic stroke. Diffusion tensor imaging data and UL function measured the Action Research Arm Test (ARAT) were collected 30 individuals with stroke prior to after TST. ANOVAs tested effects of on entire sample Responders [ΔARAT ≥ 5.8, N = 13] Non-Responders < 17] groups. Baseline fractional anisotropy (FA) values correlated ARATpost TST controlling for baseline ARAT age identify...
Alzheimer's disease (AD), which most commonly occurs in elder, is a chronic neurodegenerative with no agreed drugs or treatment protocols at present. Amnestic mild cognitive impairment (aMCI), earlier than AD onset and later subjective decline (SCD) onset, has serious probability of converting into AD. The SCD, can last for decades, subjectively complains especially memory. Distinct altered patterns default mode network (DMN) subnetworks connected to the whole brain are perceived as...
Background Pedicle screw insertion has been known to have several complications even in the most skilled surgical hands. However, injury thoracic aorta during pedicle is rare, delayed presentation secondary pseudoaneurysm rarer, formation caused by a series of malpositioned screws perhaps not reported so far. Case In this paper, we report here case which inadvertent resulted pseudoaneurysm, its manifestation was initially vague, resulting diagnosis. Delayed aortic or can be asymptomatic for...
Whether transcranial direct current stimulation (tDCS) benefits stroke rehabilitation remains unclear. To investigate how tDCS reorganizes brain circuitry, nineteen post-stroke patients underwent sessions with bi-hemispheric real vs sham intervention. Resting motor threshold measurements showed evoked higher excitability in the cortex that enhanced descending conduction from lesioned primary to target hand muscle. Granger causality analysis further revealed circuitry rewiring among...
Motion correction is an important component in fMRI brain image analysis. Linear registration technique mostly used the process based on assumption that there not any shape changes of human during imaging process. Echo planar (EPI) has been widely adapted to shorten encoding duration and increase temporal resolution. However, due magnetic field inhomogeneity caused by tissues, distortion signal intensity lose are brought into images technique. On other hand, subject's pose scanner a effect...
<h3>Background</h3> Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington’s disease (HD). <h3>Aim method</h3> In this study, we evaluated the therapeutic potential of laquinimod (1 10 mg/kg), novel immunomodulatory agent shown to be protective number neuroinflammatory conditions, YAC128 mouse model HD. <h3>Results</h3> Treatment with 6 months rescued atrophy striatum, certain cortical regions, corpus callosum HD mice. Diffusion tensor...
82 Third-year nursing students randomly were divided into experimental group (40 students) and control (42 students). There was no significant difference in teachers responsible for the two groups. Both of them taught "emergency intensive nursing". The by using traditional teaching method not only method, but also integrating comprehensive designed experiments to process. groups assessed analyzing cases, including evaluation items operation criteria. results suggest that integrated can...