A5089527218- Economic and Financial Impacts of Cancer
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Ocular Oncology and Treatments
- ECG Monitoring and Analysis
- Systemic Lupus Erythematosus Research
- Nonmelanoma Skin Cancer Studies
- Atrial Fibrillation Management and Outcomes
- Ocular Infections and Treatments
- Gut microbiota and health
- Global Cancer Incidence and Screening
- Digital Imaging in Medicine
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Corneal Surgery and Treatments
- Climate Change and Health Impacts
- Palliative Care and End-of-Life Issues
- Advanced Radiotherapy Techniques
- Aging and Gerontology Research
- Healthcare cost, quality, practices
- Brain Metastases and Treatment
- Pregnancy and preeclampsia studies
- Pharmaceutical Economics and Policy
- Cardiac Health and Mental Health
- Genomics and Phylogenetic Studies
Yale University
2021-2025
Yale New Haven Health System
2022-2023
Jackson Laboratory
2019-2022
New York University
2021
Abstract The 16S rRNA gene has been a mainstay of sequence-based bacterial analysis for decades. However, high-throughput sequencing the full only recently become realistic prospect. Here, we use in silico and experiments to critically re-evaluate potential provide taxonomic resolution at species strain level. We demonstrate that targeting variable regions with short-read platforms cannot achieve afforded by entire (~1500 bp) gene. further full-length are sufficiently accurate resolve subtle...
<h3>Importance</h3> Although there have been significant increases in the number of US residents insured through Medicaid, ability patients with Medicaid to access cancer care services is less well known. <h3>Objective</h3> To assess facility-level acceptance insurance among diagnosed common cancers. <h3>Design, Setting, and Participants</h3> This national cross-sectional secret shopper study was conducted 2020 a random sample Commission on Cancer–accredited facilities United States using...
Purpose: The mechanisms that lead to pterygium pathogenesis are poorly understood. Ultraviolet (UV) exposure is a leading environmental risk factor. We propose UV triggers the de-repression of transposable elements (TEs), including endogenous retroviruses (ERVs), and subsequently activate double-stranded RNA DNA sensors such as RIG-I cGAS. Methods: In present study, we analyzed publicly available sequencing data from healthy conjunctiva specimens. used Ingenuity Pathway Analysis (IPA)...
Demkowicz, Patrick; Kavaliauskaite, Ieva; Faulkner, Sophia C.; Kent, Candice; Shaw, Melissa; Kumar, Deepika; Ix, Joachim H.; Wilson, F. Perry; Moledina, Dennis G.; Bakhoum, Mathieu F.; Christine Y. Author Information
Private equity firms have recently acquired several large urology practices in the United States. As little is known about these acquisitions, we sought to characterize trends practice consolidation.
Growing evidence has linked an altered host fecal microbiome composition with health status, common chronic diseases, and institutionalization in vulnerable older adults. However, fewer studies have described changes healthy adults without major confounding diseases or conditions, the impact of aging on across different body sites remains unknown. Using 16S ribosomal RNA gene sequencing, we reconstructed oral microbiomes young (23–32; mean = 25 years old) (69–94; 77 community-dwelling...
Abstract Background Despite improvements in the treatment of primary uveal melanoma (UM), patients with metastatic disease continue to exhibit poor survival. Methods A retrospective review UM at Yale (initial cohort) and Memorial Sloan Kettering (validation was conducted. Cox proportional hazards regression used determine baseline factors that are associated overall survival, including sex, Eastern Cooperative Oncology Group (ECOG) Performance Status Scale, laboratory measurements,...
Abstract Uveal melanoma (UM), the most common intraocular primary cancer in adults, demonstrates a unique proclivity for liver metastasis. To understand molecular underpinnings of this organotropism, we analyzed genomic features and extrahepatic UM metastases, identifying distinct signatures that mirror clonal diversity tumors. Liver metastases were enriched BAP1 mutations exhibited higher prevalence monosomy 3 compared to metastases. Analysis tumor-liver microenvironment crosstalk at...
Abstract Purpose Corneal ulcers pose a significant threat to vision, with the need for prompt and precise pathogen identification being critical effective treatment. This study assesses efficacy of using next-generation portable sequencing (Nanopore Technology) detect identify bacterial pathogens directly from tear samples, providing non-invasive alternative traditional corneal scraping culture, which are limited by high false-negative rates. Design Prospective observational study....
6548 Background: As the result of expansions associated with Affordable Care Act (ACA), one in five Americans are now insured through Medicaid. Despite overall increases, access to care for Medicaid-insured patients cancer may be limited by facilities due lower reimbursement and administrative burden. We aimed directly assess facility-level acceptance Medicaid a new diagnosis cancer. Methods: performed cross-sectional secret shopper study evaluate colorectal, breast, urologic, skin at...
ABSTRACT Background While the US Food and Drug Administration (FDA) has cleared smart watch software for detecting atrial fibrillation (AF), there is lack of guidance on management by physicians. Methods We conducted a case-based survey physicians in primary care, emergency medicine, cardiology at Yale University California San Francisco from September to December 2021. Cases described asymptomatic patients receiving Apple Watch AF alerts; cases varied sex, race, medical (diabetes...
e18543 Background: Although Medicaid expansions associated with the Affordable Care Act (ACA) significantly increased insurance coverage for Americans cancer, there is evidence that some facilities limit number of patients they treat due to lower reimbursement. We aimed assess facility-level changes in proportion who were diagnosed cancer relation ACA. Methods: identified adult 19 most commonly cancers using National Cancer Database from 2010 through 2017. clustered Commission on (CoC)...
No AccessUrology PracticeHealth Policy1 Mar 2022Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate CancerThis article is commented on by the following:Editorial Commentary Matthew Buck, Eric Ghiraldi, Patrick Demkowicz, Henry S. Park, Yi An, Benjamin H. Kann, James B. Yu, Preston C. Sprenkle, Isaac Y. Kim, and Michael Leapman BuckMatthew Buck Department Urology, Yale School Medicine, New Haven, Connecticut Frank Netter MD Medicine at Quinnipiac University, ,...
Background: While the US FDA has cleared wearable device software for detection of irregular rhythms suggestive atrial fibrillation, there is little evidence to guide decision-making in response abnormal rhythm notifications. We evaluated physician practice patterns across specialties at 2 large academic centers. Methods: conducted a case-based survey attending and resident physicians primary care, emergency medicine, cardiology Yale UCSF from September December 2021. Case scenarios were...
Abstract Background Despite an aging population, little is known about racial disparities in aging‐specific functional impairments and mortality among older adults hospitalized for acute myocardial infarction (AMI). Methods We analyzed data from patients aged 75 years or who were AMI at 94 US hospitals 2013 to 2016. Functional geriatric conditions assessed in‐person during the hospitalization. The association between race risk of (primary outcome) was evaluated with logistic regression...
You have accessJournal of UrologyHealth Services Research: Value Care: Cost and Outcomes Measures I (MP17)1 Sep 2021MP17-03 FACILITY-LEVEL FACTORS ASSOCIATED WITH DECREASING SHARE OF UROLOGIC CANCER PATIENTS MEDICAID FOLLOWING IMPLEMENTATION THE AFFORDABLE CARE ACT Patrick Demkowicz, Matthew Buck, James Nie, Victoria Marks, Michael Leapman DemkowiczPatrick Demkowicz More articles by this author , BuckMatthew Buck NieJames Nie MarksVictoria Marks LeapmanMichael View All Author...