A5078657180- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Particle accelerators and beam dynamics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Respiratory and Cough-Related Research
- Particle Accelerators and Free-Electron Lasers
- Gyrotron and Vacuum Electronics Research
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Contact Dermatitis and Allergies
- Knee injuries and reconstruction techniques
- Insect and Pesticide Research
- Nuclear physics research studies
- Total Knee Arthroplasty Outcomes
- Drug-Induced Adverse Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Orthopedic Surgery and Rehabilitation
- Pregnancy and preeclampsia studies
- Inhalation and Respiratory Drug Delivery
- Redox biology and oxidative stress
- Advanced Breast Cancer Therapies
- Peripheral Nerve Disorders
Teikyo University
2016-2025
Kindai University
2011-2021
Kyoto University
2013-2021
Center for Rheumatology
2021
Tokushima University
2021
Teikyo University of Science
2021
Takara (Japan)
2020
Sumitomo Chemical (Japan)
2020
Teikyo University Hospital
2011-2019
Fukujuji Hospital
2019
For successful TKA, good soft tissue balance is one of the most important factors; however, it unknown whether coronal immediately after surgery maintained with time. We hypothesized, if neutral mechanical alignment was achieved at time some degree lateral ligamentous laxity could be accepted and would diminish To confirm this hypothesis, we posed two scientific questions: (1) Does ligament measured TKA change time? (2) preoperative varus correlate or medial observed TKA? in 71 knees...
Recapitulative animal models of idiopathic pulmonary fibrosis (IPF) and related diseases are lacking, which inhibits our ability to fully clarify the pathogenesis these diseases. Although lung in mouse is often induced by bleomycin, silica-induced more sustainable progressive. Therefore, this study, we sought elucidate mediator(s) responsible for fibrosis, through use a model fibrosis. With single nasal administration 16 mg silica, inflammation (assessed elevated cellular components BAL...
For the total knee arthroplasty in valgus deformed knee, superiority of medial or lateral approach is still controversial. We compared short-term result two groups. Forty-seven knees rheumatoid arthritis with deformity from 6° to 24° were randomly divided into group; (24 knees) and knees). used Scorpio NRG PS for all knees. Median postoperative periods 43 months both surgical time, alignment on standing radiograph, range motion (ROM) pre/postoperatively, degrees soft-tissue release...
Abstract BACKGROUND Cyenopyrafen is an inhibitor of complex II the mitochondrial electron transport chain. It has a molecular structure that shares some common features with frequently used I inhibitors such as pyridaben. To evaluate whether this similarity in poses cross‐resistance risk might complicate resistance management, we selected for pyridaben and cyenopyrafen laboratory characterized . RESULTS The selection conferred to vice versa. Resistance towards these both acaricides was...
The objective of the present study was to compare intraoperative use tranexamic acid (TNA) plus intra-articular diluted-epinephrine (DEP) with preoperative autologous blood donations and transfusions in reducing an allogeneic transfusion (ABT) primary unilateral total knee arthroplasty (TKA).Patients (n=133) treated TKA were divided into three groups retrospectively: patients administered assigned group A (n=51); injections TNA postoperative DEP B (n=42); drain-clamp method addition C...
To evaluate soft-tissue balance during versus after total knee arthroplasty (TKA).18 men and 75 women aged 52 to 85 (mean, 68) years who had moderate-to-severe varus deformity underwent TKAs using the Scorpio non-restrictive geometry posterior-stabilised system (Stryker Howmedica Osteonics; Allendale, [NJ], USA). All surgeries were performed by a single surgeon medial parapatellar approach. After bony procedures, was measured intra-operatively tensor/balancer device. The coronal...
Herein is reported a case of plasmablastic lymphoma (PBL) the retroperitoneum in an HIV‐negative patient. This first PBL at this location and from Japan English‐language literature. A 76‐year‐old Japanese man was admitted to hospital with chief complaint right inguinal lymph node swelling. Lymph biopsy indicated large tumor cells both diffuse cohesive growth patterns, conspicuous cell proliferation sinuses. The initial pathological diagnosis metastatic carcinoma. patient died approximately 1...
<i>Background:</i> Basophils are thought to play pivotal roles in the pathogenesis of allergic reactions, but their inflammation associated with systemic abnormalities such as metabolic disorders remain largely unknown. Advanced glycation end products (AGEs) potentially important substances produced high-glucose disease conditions. In this vitro study, we investigated whether biological functions human basophils can be influenced by AGEs. <i>Methods:</i> We analyzed...
Mepolizumab, a humanized antibody targeting interleukin-5, decreases the number of blood eosinophils and frequency exacerbation severe asthma. Galectin-10 is protein within cytoplasm constitutes Charcot-Leyden crystals, which promotes key features However, relationship between time kinetics clinical response eosinophil-derived molecules such as galectin-10 or eosinophil cationic (ECP) has not been precisely investigated.This study aimed to clarify precise course levels serum ECP after...
The noradrenergic (NA) neurons in the locus ceruleus (LC) were ablated with a high degree of selectivity by immunotoxin-mediated neuronal targeting. Transgenic mice used which human interleukin-2 receptor-α subunit (hIL-2Rα; Tac) is expressed under promoter dopamine β-hydroxylase. recombinant immunotoxin, composed Fv fragment an anti-hIL-2Rα monoclonal antibody fused to truncated form Pseudomonas exotoxin [anti-Tac(Fv)-PE38], was injected bilaterally into LC mouse. As result, LC-NA...
We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as food additive. In this study, highly pure was added to an albumin-containing buffer at various concentrations, followed serial dilution. Varying the mixing ratio and albumin affected extent histamine release from passively sensitized basophils. Similar basophil occurred with acid-globulin solutions. These results provide experimental evidence indicating that activation is dependent...
Abstract Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen a significant effect on COPD pathology is unclear. This study aimed to identify specific IgE related clinical features diagnosis asthma-COPD overlap (ACO). Methods We recruited 76 patients with analyzed 39 using panel test (View Allergy ® ). ACO was diagnosed according Japanese Respiratory Society...
Pigmented villonodular synovitis of the elbow is rare and even rarer in children. We report a case pigmented 6-year-old girl who underwent total synovectomy after diagnosis was confirmed by biopsy. The osteochondral defect at olecranon filled with calcium phosphate bone paste. Two years surgery, neither recurrence nor joint degeneration found.
Biologics are integral in the management of severe asthma. As effectiveness anti-IL-5 receptor antibody benralizumab Japan remains elusive, this study aimed to assess its real-world Japanese patients with