A5051663651- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Anesthesia and Pain Management
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Pain Management Techniques
- Nausea and vomiting management
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemodynamic Monitoring and Therapy
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Anesthesia and Sedative Agents
- Sleep and related disorders
- Traditional Chinese Medicine Analysis
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS Research and Interventions
- Folate and B Vitamins Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Electrical and Bioimpedance Tomography
- Bioactive Natural Diterpenoids Research
Cairo University
2013-2024
GTx (United States)
2024
Ain Shams University
2024
National Guard Health Affairs
2023
National Institute of Health
2020
Sultan Qaboos University Hospital
2016-2018
Royal Hospital
2018
Sultan Qaboos University
2017
Creative Commons
2017
Alexandria University
2016
Treatment of chronic hepatitis C using combination sofosbuvir (SOF) and daclatasvir (DCV) was used in several clinical trials multicentre studies, which were somewhat limited to genotypes 1-3. The national program Egypt is SOF-DCV for large scale treatment.To assess the efficacy safety combined treating patients with HCV-G4 a real-world setting.Data outcome HCV who treated 12 weeks generic medications: DCV 60 mg plus SOF 400 ± ribavirin (RBV) within treatment are presented. Treatment-naïve...
Hepatocellular carcinoma (HCC) is a common disorder worldwide and ranks 2nd 6th most cancer among men women in Egypt. HCC has rising incidence Egypt mostly due to high prevalence of viral hepatitis its complications. Proper management requires the interaction multidisciplinary clinic choose appropriate plan. The different modalities treatment include resection (surgery or transplantation), local ablation, chemoembolization, radioembolization molecular targeted therapies. This paper...
Background: Septic shock is a major healthcare problem. Adrenal insufficiency (AI) in children with septic recognized complication, yet controversial regarding its management and effect on mortality. According to the current guidelines, risk factors for AI should receive stress dose of steroids step 3 treatment. This study aimed evaluate compare early corticosteroid therapy traditional use among pediatric patients. Methods: prospective randomized interventional clinical included groups...
Quality sleep is critically imperative for facilitating learning and academic achievement among university students. Students are subject to several potential stressors during their journey which can pose far-reaching implications psychological well-being. A very limited number of studies have evaluated the association problems factors in health professions This research aimed at exploring relationship between quality Health Professions It equally important know prevalence such conditions so...
A large Egyptian treatment program for HCV was launched in2014 after the introduction of direct-acting antiviral agents (DAAs). This depended mainly on establishing specialized independent centres treatment. These represent major strengths in model care, as they provide integrated care patients and have enabled Egypt to treat more than one million 3 years. The New Cairo Viral Hepatitis Treatment Center (NCVHTC) is an example these centres.The experience management evaluated by analysing data...
Dexmedetomidine infusion improves oxygenation and lung mechanics in patients with chronic obstructive disease; however, its effect restrictive disease has not been thoroughly investigated yet. The aim of this work was to evaluate the effects dexmedetomidine on morbidly obese disease.Forty-two scheduled for bariatric surgery were included study. Patients randomized receive either at a bolus dose 1mcg/Kg followed by 1 mcg/Kg/hour 90 min (Dexmedetomidine group), or normal saline (Control...
Hepatitis C virus (HCV) infection is considered as a major public health problem that, worldwide, chronically affects 170 million people. Elderly patients are more likely than younger to have increased duration of infection, rate disease progression, and subsequently incidence advanced liver disease. Natural history models predicted that the prevalence HCV its chronic sequelae well extrahepatic manifestations will eventually increase through next decade mostly affect those who greater 60...
Abstract Background Hypothermia and shivering are common complications after spinal anaesthesia, especially uroscopic procedures in which large amounts of cold intraluminal irrigation fluids used. Magnesium sulfate dexmedetomidine the most effective adjuvants with least side effects. The aim this study was to compare effects intrathecal versus magnesium on prevention post-spinal anaesthesia shivering. Methods This prospective randomized, double-blinded controlled included 105 patients who...
Successful eradication of recurrent hepatitis C virus (HCV) infection following liver transplantation improves graft survival. This study aimed at evaluation hepatic fibrosis changes among long-term responders to DAA therapy for HCV after using noninvasive methods. Patients with significant (≥F2) who achieved SVR12 treatment DAAs were included (n = 52). Hepatic status was assessed, noninvasively, by calculation fibrosis-4 score (FIB-4) and Aspartate Aminotransferase Platelet Ratio Index...
Background Adjuvants to adductor canal block are used improve the quality and duration of for better analgesia after knee surgeries. This study evaluates compares effect adding dexamethasone neostigmine bupivacaine in blocks arthroscopy (KA). Methods In this randomized, double-blinded, controlled study, 90 patients scheduled were randomly allocated into three groups receive end arthroscopy. The control group received 20 ml 0.5%+2 normal saline, (8 mg) 0.5%+1 (500 mcg) +1 saline. Outcomes:...
There is less data regarding the changes in body mass index (BMI) after treating hepatitis C virus (HCV) patients with new direct-acting antiviral agents (DAAs). This study aimed to assess BMI chronic HCV treated DAAs Egypt and explore other factors influencing this change.The of who received therapy one Egypt's specialized viral treatment centers were retrospectively analyzed. In addition routine clinical laboratory workup, weight during monitored was calculated. Viral load measured at 12...
Abstract Background and aims NS5A inhibitors are an important option for treating chronic HCV-GT4 patients. Retreatments after NS5A-based DAAs failure limited. We aimed to determine the effectiveness safety of SOF/VEL-containing regimens HCV retreatment NS5A-regimen failure. Methods Prospective cohort study assessing efficacy with SOF/VEL in addition either voxilaprevir or ribavirin patients who had failed previous DAA treatment. The primary outcome was SVR12. Safety tolerability data were...
: The advent of direct-acting antiviral (DAA) therapy has revolutionized the treatment landscape hepatitis C virus (HCV) infection. This study aimed to provide a comprehensive research real-world effectiveness and safety DAA treatment, representing first conducted in Omani population.
The present study aimed at evaluation of the usefulness point shear wave elastography (pSWE) in characterization FLL(s) by quantifying their stiffness.In total, 197 patients (mean age was 56.57 years) with on conventional ultrasound were included. Final diagnoses, confirmed imaging and/or biopsy whenever possible, included hepatocellular carcinoma (HCC) (n = 143), metastasis 36), hemangioma 16), and focal nodular hyperplasia 2). Stiffness performed pSWE. ratio (lesion to background liver)...
Background and aims: The insulin pathway may play a role in development of colorectal cancer (CRC). In this study, we investigated associations between CRC obesity Egyptians with reference to single nucleotide polymorphisms (SNPs) the insulin-like growth factor-1 (IGF-I) gene. We also studied serum levels IGF-1in Egyptian patients different BMI values. Methods: This prospective study included 66 30 healthy individuals, for whom body mass index (BMI) was estimated, controls being categorized...
We aimed at determination of the usefulness elastography [acoustic radiation force impulse (ARFI) and FibroScan] for evaluation nonalcoholic fatty liver disease (NAFLD) patients.A prospective cross-sectional study included 60 biopsy-proven NAFLD patients (mean age: 45 years) was carried out. All were subjected to lab works, biopsy, measurement stiffness by ARFI FibroScan steatosis controlled attenuation parameter (CAP). CAP measurements adjusted presence or absence diabetes according...
Treatment of hepatitis C virus (HCV) genotype 4 patient with fixed dose combination ombitasvir-paritaprevir-ritonavir plus ribavirin (OBV/rPTV/RBV) has been proven efficacy and safety in many clinical trials. The current study reports the OBV/rPTV/RBV (for treatment-naïve), OBV/rPTV/RBV/sofosbuvir (SOF) treatment-experienced), chronic HCV patients real life settings.Prospective cohort including all adult who were scheduled to receive ± SOF for 12 or 24 weeks New Cairo Viral Hepatitis Center....
A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with infection but lacking laboratory confirmation an epidemiological link confirmed case. Our study aimed estimate the contribution Bordetella and identifying predictors its diagnosis in cohort children PLI.Demographic information were retrospectively collected from medical records < 13 years old hospitalized for...
Magnesium (Mg) has been evaluated as an adjuvant to local anesthetics for prolongation of postoperative epidural and intrathecal analgesia but not with levobupivacaine in lower abdominal surgeries.The aim the study was evaluate preemptive analgesic effect Mg added anesthesia infraumbilical surgeries.This design a prospective randomized controlled trial.Two groups, each fifty patients undergoing pelvic surgeries anesthesia. Group M received 15 ml mixture 14 0.5%, 0.5 magnesium sulfate 10% (50...