A5017728760- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Thyroid Cancer Diagnosis and Treatment
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Organ Transplantation Techniques and Outcomes
- Sinusitis and nasal conditions
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Organ Donation and Transplantation
- Lung Cancer Diagnosis and Treatment
- Connective tissue disorders research
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Infectious Diseases and Mycology
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Trauma Management and Diagnosis
- HIV/AIDS drug development and treatment
- Heat shock proteins research
Cairo University
2015-2025
Damanhour University
2025
Centro de Investigaciones Cardiovasculares
2005-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2025
Universidad Nacional de La Plata
2025
Minia University
2022
Mansoura University
2021
South Tyneside and Sunderland NHS Foundation Trust
2020
Ain Shams University
2014
Al Ain Hospital
2011
Treatment of chronic hepatitis C using combination sofosbuvir (SOF) and daclatasvir (DCV) was used in several clinical trials multicentre studies, which were somewhat limited to genotypes 1-3. The national program Egypt is SOF-DCV for large scale treatment.To assess the efficacy safety combined treating patients with HCV-G4 a real-world setting.Data outcome HCV who treated 12 weeks generic medications: DCV 60 mg plus SOF 400 ± ribavirin (RBV) within treatment are presented. Treatment-naïve...
Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. Elevated serum levels high sensitivity CRP (hs-CRP), interleukin-6 (IL-6) tumor necrosis factor alpha (TNF-alpha) reflect low-grade chronic inflammation been associated several insulin-resistant states; they are useful cardiovascular risk markers. The objective this study was to investigate whether soluble inflammatory markers altered in PCOS focusing on its relationship...
Summary Background Chronic hepatitis C virus infection is one of the most important health problems in Egypt. The Ministry Health's National Treatment Programme introduced sofosbuvir‐based therapy October 2014. Aim To assess clinical effectiveness and predictors response to SOF ‐based treatment regimens, either dual therapy, with /ribavirin ( RBV ) for 6 months or triple /peg‐ IFN ‐alfa‐2a/ 3 months, a cohort patients treated affiliated centres Methods Between 2014 end 2014, who were...
Abstract Background & Aims Major changes have emerged during the last few years in therapy of chronic HCV . Several direct acting antiviral agents been developed showing potent activity with higher rates sustained virological response, even difficult‐to‐treat patients. This study explores real life experience concerning efficacy, safety and possible predictors response for first cohort Egyptian patients genotype IV treated Sofosbuvir/Simprevir combination therapy. Methods recruited...
Study design Retrospective cohort study. Objectives To examine differences in postoperative complications, recovery course, and costs between patients with without obstructive sleep apnea (OSA) undergoing single-level anterior cervical discectomy fusion (ACDF). Methods The National Inpatient Sample (NIS) database was queried to identify ACDF 2016 2022. After exclusions, were divided into OSA control groups. Propensity score matching (1:2) controlled for age, sex, obesity, year of surgery...
Abstract The safety and efficacy of pegylated interferon (PEG‐IFN) alfa‐2a ribavirin were studied among patients treated for genotype 4 chronic hepatitis C. Ninety‐five with C PEG‐IFN (180 µg/week) plus (≥11 mg/kg/day) 48 weeks. primary end point was sustained virological response, defined as non‐detectable levels HCV RNA at the follow up (week 72). proportion response 58/95 = 61.1% (95% CI 50.5–70.9%). Side effects generally mild, well managed by dose reductions (in 62% patients); in only...
Liver stiffness measured by transient elastgraphy correlates with Hepatic vein pressure gradient, liver Stiffness value of 21 kpa predicts significant portal hypertension. Aim is to predict esophageal varices presence fibroscan and possible grading degree in HCV related cirrhotic patients.Thirty two patients were recruited, age > 18 years, BMI< 35, no history of: upper GI bleeding, hepatocellular carcinoma, abdominal collaterals, ascites. Patients underwent clinical examination, laboratory...
Summary Background Interferon‐free regimens are associated with high sustained virological response; however, adverse effects have yet to be fully reported. Aim To evaluate the different direct‐acting antiviral drug ( DAA ) in Egyptian patients. Methods This multicenter retrospective study included all during and after treatment of 149 816 chronic hepatitis C treated Patients received sofosbuvir SOF )/ribavirin RBV (n = 21 835), /simeprevir 24 215) /daclatasvir DCV 58 477), / 45 188)...
To assess the time course of phosphorylation phospholamban residues, underlying mechanisms determining these phosphorylations, and their functional impact on mechanical recovery during acidosis.Langendorff perfused rat hearts were submitted to 30 min hypercapnic acidosis. Contractility, relaxation, immunodetected by specific antibodies, determined.Acidosis produced a impairment followed spontaneous recovery, most which occurred within first 3 acidosis (early recovery). During this period,...
This study aim is to assess the prevalence of occult HCV infection among Egyptian patients with non alcoholic fatty liver disease (NAFLD) elevated AST and ALT, correlate presence severity disease. Patients Methods: After informed consent 27 elevateed enzymes diagnosed as NAFLD were examined for demographic, clinical, laboratory data Ultrasonography. Liver biopsy was done tested RNA in tissue. Genotyping using RFLP analysis PCR products 5'NCR positive cases. Results: tissue 11/27 (40.7%);...
Successful eradication of recurrent hepatitis C virus (HCV) infection following liver transplantation improves graft survival. This study aimed at evaluation hepatic fibrosis changes among long-term responders to DAA therapy for HCV after using noninvasive methods. Patients with significant (≥F2) who achieved SVR12 treatment DAAs were included (n = 52). Hepatic status was assessed, noninvasively, by calculation fibrosis-4 score (FIB-4) and Aspartate Aminotransferase Platelet Ratio Index...
The national committee for control of viral hepatitis (NCCVH) in Egypt, settled by the Ministry health, treated over one million patients around 60 centers with chronological changes drug combinations. This research aims to study health care facilities and services provided NCCVH treatment Egypt explore hinders faced.A cross-sectional operational study. Multistage random sampling technique was applied Egyptian governorates. From each stratum governorate chosen from which center randomly...
Elastometry has demonstrated good accuracy, but little is known about its reproducibility. The aim of this study was to assess the intra- and inter-operator reproducibility liver stiffness measurement among hepatitis C virus (HCV)-infected patients in Egypt. conducted HCV-infected referred for treatment evaluation two centres Cairo. Two operators took times per patient same day. Intra- inter-reproducibility were estimated by different methods: Bland Altman graphics, variation coefficient,...
Progression of recurrent hepatitis C is accelerated in liver transplant (LT) recipients. Direct-acting antivirals (DAAs) have recently emerged as a promising therapeutic regimen for the treatment virus infection. Rates sustained virological response (SVR) drastically improved since introduction DAAs. The aim to elucidate changes stiffness measurement (LSM) by transient elastography (TE) well acoustic radiation force impulse (ARFI) and fibrosis scores after DAA LT recipients with recurrence....
Objective Malnutrition is prevalent among patients with end‐stage liver disease ( ESLD) awaiting transplantation. Our aim was to examine prospectively the impact of patients' nutritional status on their outcomes after living donor transplantation LDLT ). Methods In all, 30 scheduled for were subjected a preoperative assessment through subjective global SGA ), risk screening NRS 2002) and anthropometric measurements. All followed up 3 months mortality, graft rejection, number clinically...
Objectives The introduction of direct acting antivirals (DAAs) has resulted in very high sustained virological response rates (SVR) patients with chronic hepatitis-C (CHC). There are still a minority who fails to achieve SVR. This study aims identify simple factors associated nonresponse DAAs using routine pretreatment workup. Methods A retrospective included 10 655 CHC were candidates for anti-viral therapy. Pretreatment demographics, laboratory results, ultrasonography and FIB-4were...
The ability to obtain primary long-term cultures of human foetal hepatocytes maintaining liver differentiation characteristics in serum-free medium prompted us test their susceptibility hepatitis C virus infection. Using PCR, we detected the presence HCV RNA-positive strand supernatants and cells virus-infected hepatocyte cultures, at various times post-infection. Evidence effective genome replication multiplication was also based on time-dependent appearance putative RNA-negative strand,...
Hepatitis C virus (HCV) is a major public health problem. Soluble CD14 (sCD14) level was shown to be associated with HCV infection. In this study, we aimed investigate the relationship between sCD14 concentration and disease progression, as well response pegylated interferon/ribavirin (peg-IFN/RBV) therapy in Egyptian patients chronic hepatitis (CHC). The ELISA technique used test 80 CHC 20 healthy control persons for serum levels of (pretreatment after 12 weeks treatment). were 65 males 15...