A5001097998- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Acute Kidney Injury Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Diet, Metabolism, and Disease
- Nanoplatforms for cancer theranostics
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Urinary Tract Infections Management
- PARP inhibition in cancer therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related gene regulation
- Simulation-Based Education in Healthcare
- Muscle and Compartmental Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Extracellular vesicles in disease
- RNA Research and Splicing
- Anatomy and Medical Technology
- Photodynamic Therapy Research Studies
Zhejiang University
2019-2024
Sir Run Run Shaw Hospital
2019-2024
Qingdao University
2023-2024
Wuhan University of Science and Technology
2022
People 's Hospital of Jilin Province
2020
Cuproptosis was characterized as a novel type of programmed cell death. Recently, however, the role cuproptosis-related long noncoding RNAs (CRLs) in tumors has not yet been studied. Identifying predictive CRL signature hepatocellular carcinoma (HCC) and investigating its putative molecular function were goals this work. Initially, Pearson’s test used to assess relationship between lncRNAs cuproptosis-associated genes obtained from HCC data The Cancer Genome Atlas (TCGA). By implementing...
Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes AKI. Nevertheless, an efficient therapeutic approach for AKI development still lacking due to its elusive pathogenetic mechanism. Here, we showed that chitosan oligosaccharide (COS), a natural oligomer polysaccharide degraded from chitosan, significantly...
The clinical management of patients with COVID-19 and cancer is a Gordian knot that has been discussed widely but not reached consensus. We introduced two-sample Mendelian randomization to investigate the causal association between genetic predisposition cancers susceptibility severity. Moreover, we also explored mutation landscape, expression pattern, prognostic implications genes involved in distinct cancers. Among all types analyzed, only lung adenocarcinoma was causally associated...
Aberrant methylation is a hallmark of hepatocellular carcinoma and plays an important role in tumor initiation progression. However, the epigenome-wide patterns portal vein thrombosis (PVTTs) have not been fully explored. Here, we performed DNA adjacent normal tissues (ANTs), paired PVTTs using Infinium HumanMethylation450 array (n = 11) conducted Sequenom EpiTYPER assays to confirm aberrantly methylated genes. MTS apoptosis assay were used assess synergistic effect two drugs on HCC cell...
Precision medicine is the ultimate goal for current disease therapies, including tumor and infection. The lack of specific targeted drugs liver cancer anti-infective in treatment diabetic foot ulcer with infection (DFI) are representative obstacles those 2 major diseases currently plaguing human beings. Inventing natural biocompatible polymers derived from materials one main development directions bio-medical materials. Though previous studies have demonstrated potential application values...
Objective This study aims to evaluate the effectiveness of Vaginal Microecology Evaluation System (VMES) in assessing dynamics vaginal microbiome (VM) throughout process vitro fertilization and embryo transfer (IVF-ET). Furthermore, it seeks explore potential correlation between distinct types VM ecology success rate IVF-ET. Methods employed VMES ascertain composition VM. Data were collected from infertile women who underwent their initial IVF-ET treatment for tubal factor January 2018...
Hepatocellular carcinoma (HCC), a common primary liver cancer, is the third leading cause of death worldwide. DNA methylation changes are in HCC and have been studied to be associated with hepatocarcinogenesis. In our study, we used MassARRAY® EpiTYPER technology investigate differences deleted cancer 1 (DLC1) (isoform 3) promoter between tissues corresponding adjacent noncancerous association levels clinicopathological features. addition, modified CRISPR-Cas9 system methyltransferase...
In order to reduce the burden of medical PSG testing, we proposed a system or way for preliminary screening OSA and rehabilitation self-examinations patients with moderate severe in family units. The snoring vibrations 28 sets data were collected by this system. And then, performing segmentation processing acquired signals time domain obtain snore silence segments, two methods based on which SSI-Diagnostic Method $\xi $ -Diagnostic Method. All divided into 4 groups, Apnea Hypopnea Index...
Obesity is reaching epidemic proportions in the developed world. The biosynthesis and degradation of human glycoproteins take place at highest level liver. However, association between glycosylation factors affecting obesity metabolism-associated steatohepatitis (MASH) still unclear.
Objective Acute kidney injury (AKI), a syndrome with high morbidity and mortality worldwide, frequently arises from renal ischemia-reperfusion (I/R) injury, particularly in surgical contexts. Despite extensive research, effective therapies for both AKI its progression to interstitial fibrosis remain elusive. This study investigates the potential therapeutic efficacy of glucosamine (GS), an endogenous amino sugar, alleviating I/R-induced AKI. Methods A murine I/R model was utilized evaluate...
Lung injury and pulmonary fibrosis contribute to morbidity mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine (NAG), an acetylated derivative of glucosamine, has been proposed a potential protector function several types diseases. The mechanism by which NAG protects against injury, however, remains unclear. Here, we show that treatment improves bleomycin...
While abnormal neuroimaging features have been reported in patients suffering from right temporal lobe epilepsy (rTLE), the value of altered degree centrality (DC) as a diagnostic biomarker for rTLE has yet to be established. As such, present study was designed examine DC abnormalities order gauge utility these features. In total, 68 with and 73 healthy controls (HCs) participated this study. Imaging data were analyzed using receiver operating characteristic (ROC) methods. Ultimately, found...