Takuya Hemmi
A5091025221- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Inhalation and Respiratory Drug Delivery
- Vaccine Coverage and Hesitancy
- Bacillus and Francisella bacterial research
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
Kyoto University
2024
National Institute of Infectious Diseases
2021-2023
Tokyo University of Science
2022
One safety concern during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine development has been the vaccine-associated enhanced disease, which is characterized by eosinophilic immunopathology and T helper cell type (T
SUMMARY Background The immune profile against SARS-CoV-2 has dramatically diversified due to a complex combination of exposure vaccines and infection by various lineages/variants, likely generating heterogeneity in protective immunity given population. To further complicate this, the Omicron variant, with numerous spike mutations, emerged. These circumstances have created need assess potential evasion individuals histories. Methods neutralization susceptibility variants including their...
The immune responses to SARS-CoV-2 variants in COVID-19 cases are influenced by various factors including pre-existing immunity via vaccination and prior infection. Elucidating the drivers for upgrading neutralizing activity with will aid improving booster vaccines enhanced cross-protection against antigenically distinct variants, Omicron sub-lineage BA.4/5. This study revealed that magnitude breadth of neutralization after breakthrough infections determined primarily upper respiratory viral...
Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts up-conformation. However, whether also interacts with RBD down-conformation facilitate conformational shift RBD-up remains unclear. Herein, we present structures of BA.2.86 JN.1 proteins bound ACE2. Notably, successfully observed ACE2-bound down-RBD, indicating an...
In early 2020, developing vaccines was an urgent need for preventing COVID-19 from a contingency perspective. S-268019-a is recombinant protein-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprising modified spike protein antigen adjuvanted with agatolimod sodium, Toll-like receptor-9 agonist. the preclinical phase, it administered intramuscularly twice at 2-week interval in 7-week-old mice. Immunogenicity assessed, and mice were challenged...
The stalk domain of influenza virus envelope glycoprotein hemagglutinin (HA) constitutes the axis connecting head and transmembrane domains, plays pivotal roles in conformational rearrangements HA for infection. Here we characterized molecular interactions between anti-HA neutralization antibody F11 A(H1N1)pdm09 to understand structural basis actions modifications this antibody. In silico analyses using a model trimeric ectodomain indicated that Fab fragment has physicochemical properties,...
Abstract To control the coronavirus disease 2019 (COVID-19) pandemic, there is a need to develop vaccines prevent infection with severe acute respiratory syndrome 2 (SARS-CoV-2) variants. One candidate nasal vaccine capable of inducing secretory IgA antibodies in mucosa upper tract, initial site infection. However, regarding development COVID-19 vaccines, concern about potential risk lung eosinophilic immunopathology as vaccine-associated enhanced result T helper (Th2)-dominant adaptive...
Abstract: Immunity to SARS-CoV-2 in COVID-19 cases has diversified due complex combinations of exposure vaccination and infection. Elucidating the drivers for upgrading neutralizing activity with pre-existing immunity will aid understanding improving booster vaccines enhanced cross-protection against antigenically distinct variants. This study revealed that magnitude breadth neutralization responses infection breakthrough infections are determined by upper respiratory viral load...