A5024115174- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
- Pelvic floor disorders treatments
- Neonatal and Maternal Infections
- Inflammatory Biomarkers in Disease Prognosis
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Synthesis and biological activity
- Medical Malpractice and Liability Issues
- ECG Monitoring and Analysis
- Synthesis and Reactions of Organic Compounds
- Synthesis of β-Lactam Compounds
- Cervical Cancer and HPV Research
- Thermoregulation and physiological responses
- Climate Change and Health Impacts
- Synthesis and Characterization of Heterocyclic Compounds
- COVID-19 and healthcare impacts
- Immune cells in cancer
Sechenov University
2021-2024
City Clinical Hospital
2019-2024
Science & Technology Park (Czechia)
2024
Moscow State University
2024
Lomonosov Moscow State University
2024
Moscow City Hospital No 29
2022
Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave has been ongoing since end 2021. It is caused by a virus variant B.1.1.529, also known as "Omicron" and its descendants. effectiveness major vaccines Omicron not known. purpose this study to evaluate efficacy Sputnik V vaccine. main goal assess protection hospitalization period dominance. We conducted our based on large clinical center Moscow (Russia)...
COVID-19 is an infectious disease caused by the beta-coronavirus SARS-CoV-2 that in 2020 has spread worldwide. In most severe patients, clinical picture begins with respiratory failure further deteriorating up to multiple organ failure. Development of coagulopathy adverse prognostic. Analyzing currently available data revealed 71.4 % and 0.6 survivors fatal cases, respectively, demonstrated signs overt disseminated intravascular coagulation (DIC). Monitoring D-dimer level, prothrombin time,...
The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk bleeding, moderate thrombocytopenia, high plasma fibrinogen as well complement components level the areas thrombotic microangiopathy. clinical picture is not typical for classic DIC. This review systematizes pathogenetic mechanisms hypercoagulation sepsis its extreme forms patients with COVID-19. latter consist...
Non-invasive methods for determining blood hemoglobin (Hb) concentration are urgently needed to avoid the painful and time-consuming process of invasive venous sampling. Many such rely on assessing average attenuation light over a tissue area where is dominant chromophore, without separating those areas corresponding vessels bloodless tissue. In this study, we investigate whether it possible determine levels in by changes intensity when passing through large comparison adjacent tissues,...
The pandemic of a novel coronavirus infection COVID-19 has become real challenge to the mankind and medical community raised number social issues. Based on currently available information clinical cases, it follows that patients in critical condition exhibit picture disseminated intravascular coagulation (DIC), septic shock with developing multiple organ failure, which justifies use anticoagulant therapy patients. In addition isolating virus RNA from biological material polymerase chain...
ТОМ 3, № 2 1 ФУНДАМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ МЕДИЦИНА ® Редакционный совет Академик РАН, проф.В.Г.Акимкин (Москва, Россия) Проф.М. Абу-Абддаллах (Ливан) проф
Introduction . Currently, endothelial dysfunction caused by inflammation and immunothrombosisis considered as one of the crucial mechanisms in developing SARS-CoV-2 virus-mediated coronavirus disease 2019 (COVID-19). A mass damage followed release untypical large quantity von Willebrand factor (vWF) multimers subsequent consumption metalloproteinase ADAMTS-13 (a disintegrin with a thrombospondin type 1 motif, member 13) is described during severe COVID-19. The activation innate immune cells...
Introduction . During pregnancy COVID-19 poses a serious threat to both maternal health and of paired unborn child. Pregnant women have high probability complications due respiratory viral infections followed by developing critical conditions caused physiologically altered immune cardiopulmonary systems. However, asymptomatic in pregnant may be accompanied fetal inflammatory response syndrome (FIRS) that results unfavorable sequelae for neonatal life health. Aim : assess resulting from...
One of the tasks hospital-s clinical pharmacologists service is to continuously monitor consumption antimicrobial drugs (DDD analysis) depending on microbiological and epidemiological situation in hospital. This necessary for implementation various medical programs technologies aimed at reducing selection pressure risk emergence, accumulation, spread bacteria strains with multiple and/or extreme drug resistance these hospital environment. To date, some institutions, especially regions...
Vulvar cancer is a rare malignant tumor with the incidence rate of 3–8 % total female genital diseases. This disease 4th common cause mortality (after cervical, endometrial and ovarian cancers) accounts for 18.2 lethal outcomes. The anatomical structure external organs their extensive lymphatic vascular networks contribute to aggressive course, trend metastasize rapid growth. Progress in timely diagnosis vulvar vaginal directly linked increased competence oncological vigilance among general...
Numerous studies have proven a close relationship between inflammatory diseases and the state of hypercoagulability. In fact, thromboembolic complications represent one main causes disability mortality in acute chronic diseases, cancer obstetric complications. Despite this, processes hemostasis immune responses long been considered separately; currently, work is underway to identify molecular basis for such systems. It has identified that various pro-inflammatory stimuli are capable...
Objective. Development of local clinical protocols for antibacterial therapy COVID-19-associated bacterial pneumonia in the therapeutic department city hospital based on an analysis treatment process patients with pneumonia. Materials and Methods. A retrospective 1382 cases hospitalization period from 2020 to 2021 was carried out. The structure etiotropic therapy, frequency timing microbiological studies biomaterial, manifestations main markers infection during dynamic monitoring laboratory...
Our knowledge regarding chemical structure and properties of heparin its derivatives, including biological in blood plasma, on the cell surface while interacting with receptors, has been progressively growing. New insights are followed by expansion therapeutic opportunities indications for use heparins. There prerequisites creation new generation drugs modified that reduce a bleeding risk applied non-anticoagulant goal. The allow to consider it as candidate pathogenetic treatment patients...
As shown by numerous studies conducted during the pandemic, severe course of COVID-19 is accompanied multiple organ failure. Cytokine storm, hypercoagulation, complement hyperactivation and other arms comprise overall picture pathogenesis disease course. The frequent diagnosis microvascular thrombosis in lung, heart, kidneys, as well presence platelet-fibrin thrombi there signs terminal damage, suggest a possible involvement thrombotic microangiopathy (TMA) development In this regard, it...
<title>Abstract</title> Non-invasive assessment of haemoglobin (Hb) level in blood is a hot spot point-of-care biomedical diagnostics. Several optical methods are suggested as solution, some them being approved for clinical use. Still, there no consensus on the accuracy techniques, quality Hb different tissue sites, and whether combined use several techniques can improve prediction. In this work we examined capabilities two — diffuse reflectance spectroscopy RGB-imaging skin fingernails...
Non-invasive assessment of haemoglobin (Hb) level in blood is a hot spot the point-of-care biomedical diagnostics. Several optical methods are suggested as solution, some them being approved for clinical use. Still, there no consensus on accuracy techniques, quality Hb different tissue sites, and ability combined use several techniques to improve prediction. In this work we examined capabilities two techniques-diffuse reflectance spectroscopy RGB-imaging skin fingernails areas-in detecting...
The novel coronavirus epidemic is characterized by high rates of morbidity and relatively mortality. Laboratory test results in patients include leukopenia, an increase liver function tests ferritin levels reaching hundreds, sometimes thousands units. These data remind us about the macrophage activation syndrome (MAC). Secondary hemophagocytic lymphohistiocytosis syndrome, MAC, which pathogenesis based on a defect mechanisms T-cell cytotoxicity decreased level natural killer cells associated...
BACKGROUND: Computed tomography is the method of choice for assessing volume lung damage in viral pneumonia, including those associated with COVID-19. In addition, computed can determine main vessels size thorax. This allowed us to analyze relationship between severity COVID-19 and changes diameters pulmonary artery (PA) ascending aorta (Ao). Dilation PA a sign hypertension. The study these patterns may be clinical significance determining treatment tactics prognosis course disease.
...
A significant increase in sales of antibacterial drugs pharmacies and their purchases by medical institutions the Russian Healthcare System was observed against background past pandemic a novel coronavirus infection Russia. Microbiological monitoring that carried out at City Clinical Hospital No. 67 named after. L. A. Vorokhobov (Moscow) 2020–2021, revealed pressing problem — primarily gram-negative bacteria, with predominance multidrug-resistant (MDR) strains, were isolated from patients...
Activation of NETosis processes has been detected in numerous autoimmune and non-autoimmune diseases with increasing concentrations antiphospholipid antibodies (APA). Neutrophil extracellular traps (NETs) are an important activator the coagulation cascade integral component arterial venous clots cancer patients. Therefore, APA NETs may be links pathogenesis thrombosis Objective. To evaluate severity NETosis, hemostatic system activation circulation (anti-β2-glycoprotein 1 (anti-β2-GPI))...
Immunothrombosis, tumor progression and metastasis are inextricably linked. These close interactions carried out by several actors. Neutrophils considered as players in the antimicrobial host defense. Activated neutrophils release extracellular traps (NETs) involved immune response pathogenesis of various conditions including growth. interleukin-8 (IL-8) play a key role formation NETs. Objective. To evaluate interaction between NETs IL-8, their contribution to development immunothrombosis...