A5078501558- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- COVID-19 Clinical Research Studies
- Biofuel production and bioconversion
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Mathematics and Applications
- Constructed Wetlands for Wastewater Treatment
- Enzyme-mediated dye degradation
- Natural Compound Pharmacology Studies
- Microbial Metabolic Engineering and Bioproduction
- Microbial Inactivation Methods
- Preterm Birth and Chorioamnionitis
- vaccines and immunoinformatics approaches
- Livestock Management and Performance Improvement
- Genetic and phenotypic traits in livestock
- Tannin, Tannase and Anticancer Activities
- Genetics, Aging, and Longevity in Model Organisms
- Enzyme Production and Characterization
- Plasma Applications and Diagnostics
Institute of Advanced Study in Science and Technology
2019-2025
Translational Health Science and Technology Institute
2022-2023
Cotton University
2021-2023
Institute of Liver and Biliary Sciences
2022
Kempegowda Institute of Medical Sciences
2019
Pondicherry University
2017
KPC Medical College and Hospital
2013
Queen Mary University of London
2006
Since the hypothesis of Dr. Elie Metchnikoff on lactobacilli-mediated healthy aging, several microbes have been reported to extend lifespan with different features aging. However, a microbe affecting diverse aging is choice for broader acceptance and marketability as next-generation probiotic. We employed Caenorhabditis elegans model understand potential Lactobacillus plantarum JBC5 (LPJBC5), isolated from fermented food sample longevity well their underlying mechanisms. Firstly, LPJBC5...
Cold atmospheric pressure (CAP) plasma has a profound effect on protein-protein interactions. In this work, we have highlighted the deactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein by CAP treatment. Complete binding to human ACE2 was observed within an exposure time 5 minutes which is correlated higher concentration hydrogen peroxide formation due interaction with reactive oxygen species present in plasma. On other hand, established that also capable...
Microbes evolve rapidly by modifying their genomes through mutations or the horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. We conducted a multicentric study in India collected different clinical samples for decoding genome sequences bacterial pathogens associated sepsis, urinary tract infections, respiratory infections to understand functional potency AMR its dynamics. Genomic...
Lactiplantibacillus species are extensively studied for their ability to regulate host immune responses and functional therapeutic potentials. Nevertheless, there is a lack of understanding on the mechanisms interactions with hosts during immunoregulatory activities. Two plantarum strains MKMB01 MKMB02 were tested probiotic potential following Indian Council Medical Research (ICMR) guidelines. Human colorectal adenocarcinoma cells such as HT-29, caco-2, human monocytic cell THP-1 also used...
Severe coronavirus disease 2019 (COVID-19) is associated with systemic hyper-inflammation. An adaptive interaction between gut microbiota and host immune systems important for intestinal homeostasis regulation. The association of microbial composition functions COVID-19 severity sparse, especially in India. We analysed faecal diversity abundances a cohort Indian patients to identify key signatures the ecology severe as well response different therapies. microbiome was characterized using...
Since its advent, the pandemic has caused havoc in multiple waves due partly to amplified transmissibility and immune escape vaccines. Delhi, India also witnessed brutal peaks causing exponential rise cases. Here we had retrospectively investigated clade variation, emergence of new lineages varied clinical characteristics during those three order understand trajectory ongoing pandemic. In this study, a total 123,378 samples were collected for time span 14 months (1 June 2020 3 August 2021)...
Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since mirrors variations in lifestyle environment, whether associations disease conditions are consistent across populations-particularly communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists-remains unknown. Cardiovascular diseases leading cause of mortality India affecting 55 million people, high blood pressure is one primary risk...
Fermented rice beverages are consumed globally, especially in Southeast Asia. In India, such by a substantial population of ethnic communities. this study, the gut bacterial diversity beverage drinkers from Assam, India (n = 27) was compared with that nondrinkers 21) next-generation sequencing (NGS) fecal metagenomic 16S rDNA, which indicated changes 20 genera. Further, mice 6, per treatment group) were gavaged daily for 30 days different fractions beverage, included (RB), soluble (SF), and...
Our study investigated how a traditional drink called Apong, made from fermented rice, affects the gut and health of Mishing community in India. We compared two groups people who Apong to group do not it. To accomplish this, we studied bacteria, fecal metabolites, blood samples participants. It was found that drank had higher pressure but lower sugar protein levels than did also microbiome composition different those Moreover, isovaleric acid their feces. Overall, this shows like can affect...
Summary Background Since identification, infections by new SARS-CoV-2 variant Omicron are rapidly increasing worldwide. There is huge gap of knowledge regarding virus behaviour in the population from low and middle income countries. Delhi being unique with a high seropositivity vaccination rate against COVID-19 infection. We aimed to study epidemiological clinical presentations few early cases community spread infection state. Methods This prospective where respiratory specimen all RT-PCR...
Background: The burden of antimicrobial resistance (AMR) continues to rise at an alarming rate, posing a significant challenge its containment, especially in developing countries, owing the rapid emergenceof bacterial pathogens.Methods: Clinical samples collected different hospitals were inoculated selective media for pathogen isolation and characterization by 16S rRNA gene sequencing. Whole genome sequencing clinical strains (n=203) was performed using MiSeq platform. whole-cell proteome...
Background: Since its advent, the pandemic has caused havoc in multiple waves due partly to amplified transmissibility and immune escape vaccines. Delhi also witnessed brutal peaks causing exponential rise cases. Here we had retrospectively investigated clade variation, emergence of new lineages varied clinical characteristics during those three order understand trajectory ongoing pandemic.Methods: In this study a total 1,23,378 samples were collected for time span fourteen months (1st June...
The objective of this article is to determine whether low-birth-weight (LBW) infants have the capacity modulate minute ventilation achieve a CO2 set-point within ranges acceptable clinicians during procedure designed identify best dynamic compliance loops. By using flow-loop mechanics, we performed prospective stepwise reduction tidal volume (by peak inspiratory pressure, keeping end-expiratory pressure constant), in group LBW steepest slope flow-loop. We used flow-synchronized,...
BACKGROUND: Fetal weight measurement by ultrasonographic methods can be considered as an important modality for antenatal prediction of fetal (preferable single USG should done at 34-36.9wks) to rule out various complications pregnancy such macrosomia, IUGR etc which enable us prepared the delivery baby and prevent any further dreaded resulting these conditions including shoulder dystocia, severely compromised AIM: To compare accuracy predicted birth measurements obtained just before...