A5005983934- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pancreatic function and diabetes
- Advanced Sensor and Energy Harvesting Materials
- Advanced Fluorescence Microscopy Techniques
- Hydrogels: synthesis, properties, applications
- Spectroscopy and Chemometric Analyses
- Electrohydrodynamics and Fluid Dynamics
- Diabetes Management and Research
- Advanced optical system design
- bioluminescence and chemiluminescence research
- Enzyme Catalysis and Immobilization
- Optical Coatings and Gratings
- Nanocomposite Films for Food Packaging
- Surfactants and Colloidal Systems
- Neuroscience and Neural Engineering
- Proteoglycans and glycosaminoglycans research
- Cell Image Analysis Techniques
Polymer Institute of the Slovak Academy of Sciences
2018-2021
Slovak Academy of Sciences
2014-2021
International Society for Optics and Photonics
2018
Minimizing the foreign body reaction to polyimide-based implanted devices plays a pivotal role in several biomedical applications. In this work, we propose materials exhibiting nonbiofouling properties and Young's modulus reflecting that of soft human tissues. We describe synthesis, characterization, vitro validation poly(carboxybetaine) hydrogel coatings covalently attached polyimide substrates via photolabile 4-azidophenyl group, incorporated chains at two concentrations 1.6 3.1 mol %. The...
A next-generation cure for type 1 diabetes relies on immunoprotection of insulin-producing cells, which can be achieved by their encapsulation in microspheres made non-covalently crosslinked hydrogels. Treatment success is directly related to the microsphere structure that characterized localization polymers constituting hydrogel material. However, due lack a suitable analytical method, it presently unknown how changes vivo, complicates evaluation different approaches. Here, confocal Raman...
Long-term delivery of growth factors and immunomodulatory agents is highly required to support the integrity tissue in engineering constructs, e.g., formation vasculature, minimize immune response a recipient. However, for proteins with net positive charge at physiological pH, controlled from negatively charged alginate (Alg) platforms challenging due electrostatic interactions that can hamper protein release. In order regulate such between Alg matrix, we propose complex interest this study...
In this study, we developed a high-throughput microchannel emulsification process to encapsulate pancreatic beta cells in monodisperse alginate beads. The builds on stirred and internal gelation method previously adapted cell encapsulation. Alginate bead production was achieved by flowing 0.5-2.5% solution with CaCO3 across 1-mm thick polytetrafluoroethylene plate 700 × 200 μm rectangular straight-through channels. beads ranging from 1.5-3 mm diameter were obtained at rates exceeding 140...
The last decade has witnessed a rapid growth of nanoscale-oriented biosensors that becomes one the most promising and rapidly growing areas modern research. Despite significant advancements in conception such biosensors, are based at evaluation molecular, or protein interactions. It is however becoming increasingly evident functionality living system does not reside genome individual proteins, as no real biological expressed these levels. Instead, to comprehend true functioning system, it...