A5003739390- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Heme Oxygenase-1 and Carbon Monoxide
- Crystallography and molecular interactions
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Infective Endocarditis Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive Physiology in Livestock
- Metalloenzymes and iron-sulfur proteins
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Hemostasis and retained surgical items
- Thermal Regulation in Medicine
- Metal-Catalyzed Oxygenation Mechanisms
- Plant Stress Responses and Tolerance
- Pericarditis and Cardiac Tamponade
- Biochemical effects in animals
- Animal health and immunology
- Gastroesophageal reflux and treatments
- Clinical Nutrition and Gastroenterology
- Pharmaceutical studies and practices
- Abdominal vascular conditions and treatments
- Sepsis Diagnosis and Treatment
Jena University Hospital
2013-2020
Friedrich Schiller University Jena
2008-2020
University of Arizona
2013
Delayed cerebral vasospasm is the most common cause of mortality and severe neurological impairment in patients who survive subarachnoid hemorrhage. Despite improvements field diagnostic imaging, options for prevention medical treatment-primarily with calcium channel antagonist nimodipine or hemodynamic manipulations-are insufficient. Previous studies have suggested that heme bilirubin oxidation end products, originating from degraded hemoglobin around ruptured blood vessels, are involved...
Rationale: Delayed ischemic neurological deficit is the most common cause of impairment and unfavorable prognosis in patients with subarachnoid hemorrhage (SAH). Despite existence neuroimaging modalities that depict onset accompanying cerebral vasospasm, preventive therapeutic options are limited fail to improve outcome owing an insufficient pathomechanistic understanding delayed perfusion deficit. Previous studies have suggested BOXes (bilirubin oxidation end products), originating from...
Four endogenous products of oxidative bilirubin degradation were isolated and fully characterized. The constitutional isomers belong to the propentdyopents (PDPs). Their structures further transformations biologically active oxidation end (Z-BOXes) are reported. Using liquid chromatography–mass spectrometry protocols, PDPs detected in human bile gallstones. Given recent interest BOXes as effectors cerebral vasospasms liver dysfunction, co-occurring represent an additional potentially...
Abstract The oxidation of the hexacarbonyl(1,3‐dithiolato‐ S , ′)diiron complexes 4a – 4c with varying amounts dimethyldioxirane (DMD) was systematically studied. chemoselectivity products depended upon substituent R (R=H, Me, 1/2 (CH 2 ) 5 ). For R=H, four products, 6a 6d have been obtained. In case R=Me, three 7a 7c were formed, and for R=1/2 only complex 8 observed. These observations are due to steric electronic effects caused by R. Additionally, triiron DMD performed yield 9a 9b . X‐Ray...
The selective total synthesis of the pure Z-isomer BOX A (8a), a product oxidative heme degradation with significant physiological impact, was achieved in four to six steps starting from 3-bromo-4-methylfuran-2,5-dione (1). Z-BOX forms strong hydrogen bridge framework crystalline state. LC-MS techniques allow identification and characterization isomeric A.
Biliverdin and bilirubin were previously considered end products of heme catabolism; now, however, there is evidence for further degradation to diverse bioactive products. Z-BOX A B arise upon oxidation with unknown implications hepatocellular function integrity. We studied the impact on hepatic functions explored their alterations in health cholestatic conditions.Functional mechanisms investigated rats, hepatocytic HepG2 HepaRG cells, human immortalized hepatocytes, isolated perfused...
A new bilirubin oxidation end product (BOX) was isolated and characterized. The formation of the so-called Z-BOX C proceeds from via propentdyopents as intermediates. This BOX detected in pathological human bile samples using liquid chromatography/mass spectrometry has potential relevance for liver dysfunction cerebral vasospasms.
Abstract The degradation of chlorophyll, the omnipresent green pigment, has been investigated intensively over last 30 years resulting in many elucidated tetrapyrrolic products. With a comparison to structurally similar heme, we hereby propose novel additional chlorophyll mechanism mono‐ and dipyrrolic This is first proof occurrence family dipyrrols leaves that are previously only known as heme product also found spit feces herbivores with specific metabolomic patterns reflecting origin...
Two new complexes in which 2-phenylazopyridine (pap) chelates iron hydrogenase mimics, 1,2-(μ-benzenedithiolato)-2′-phenylazopyridinediirontetracarbonyl and 1,3-(μ-propanedithiolato)-2′-phenylazo- pyridinediirontetracarbonyl have been synthesized fully characterized, including X-ray crystal structure determinations. The electronic structures of the two are compared with analogous 1,2-(μ-benzenedithiolato)diironhexacarbonyl 1,3-(μ-propanedithiolato)diironhexacarbonyl complexes. Based on...
Delayed cerebral ischemia (DCI) caused by vasospasm is the leading determinant of poor outcome and mortality in subarachnoid hemorrhage (SAH) patients, but current treatment options lack effective prevention therapy. Two substance families heme degradation products (HDPs), bilirubin oxidation end (BOXes) propentdyopents (PDPs), are elicitors pathologic hypoperfusion after SAH. Z-configured HDPs can be photoconverted into corresponding E-isomers. We hypothesize that photoconversion a...