A5007635358- Pain Management and Opioid Use
- Sports injuries and prevention
- Pain Mechanisms and Treatments
- Muscle activation and electromyography studies
- Muscle Physiology and Disorders
- Sports Performance and Training
- Pharmacological Effects and Toxicity Studies
- Cancer Treatment and Pharmacology
- Exercise and Physiological Responses
- Pain Management and Treatment
- Diet and metabolism studies
- Pediatric Pain Management Techniques
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Pain Management and Placebo Effect
- Pharmacology and Obesity Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Adipose Tissue and Metabolism
- Cancer survivorship and care
- Epigenetics and DNA Methylation
- Myofascial pain diagnosis and treatment
- Migraine and Headache Studies
- Spondyloarthritis Studies and Treatments
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
Fondazione Salvatore Maugeri
2005-2024
Istituti Clinici Scientifici Maugeri
1990-2020
Istituti di Ricovero e Cura a Carattere Scientifico
1994-2020
ISI Foundation
2000
Centro Clinico Nemo
1994
University of Utah
1994
Needle biopsy samples were taken from vastus lateralis muscle (VL) of five male body builders (BB, age 27.4+/-0.93 years; mean+/-s.e.m.), who had being performing hypertrophic heavy resistance exercise (HHRE) for at least 2 years, and active, but untrained control subjects (CTRL, 29.9+/-2.01 years). The following determinations performed: anatomical cross-sectional area volume the quadriceps VL muscles in vivo by magnetic resonance imaging (MRI); myosin chain isoform (MHC) distribution whole...
The aim of the present study was to define chronic effects neuromuscular electrical stimulation (NMES) on properties human skeletal muscle. Eight young healthy male subjects were subjected 25 sessions isometric NMES quadriceps muscle over an 8-wk period. Needle biopsies taken from vastus lateralis before and after training. training status, myosin heavy chain (MHC) isoform distribution, global protein pattern, as assessed by proteomic analysis, widely varied among at baseline prompted...
A combination of in vivo and vitro analyses was performed to investigate muscular neural adaptations the weaker (nondominant) quadriceps femoris muscle one healthy individual short-term electrostimulation resistance training. The increase maximal voluntary strength (+12%) accompanied by (cross-education effect increased activation) (impairment whole-muscle contractile properties). Significant changes myosin heavy chain (MHC) isoforms relative content (+22% for MHC-2A -28% MHC-2X),...
Background: The aim of this study was to identify potential variables influencing the clinical presentation breakthrough cancer pain (BTP). Methods: Cancer patients with a diagnosis BTP were enrolled. Demographic and characteristics, as well background characteristics collected. Multivariate analyses conducted assess correlation between examined. Results: Data 4016 analysed. Average daily number episodes 2.4, mean intensity 7.5, duration 43.3 min. A short onset observed in 68.9% patients. In...
INTRODUCTION: Human skeletal muscle displays an epigenetic memory of resistance exercise induced by hypertrophy. It is unknown, however, whether high-intensity interval training (HIIT) also evokes memory. This study employed repeated intervention interspersed with a detraining period to assess HIIT. METHODS: Twenty healthy subjects (25±5yrs) completed two HIIT interventions (training and retraining) lasting 2 months, separated 3 months detraining. Measurements at baseline, after training,...
ABSTRACT Introduction: The aim of this study was to understand the effects short‐term glucocorticoid administration in healthy subjects. Methods: Five men received dexamethasone (8 mg/day) for 7 days. Vastus lateralis muscle biopsy and knee extension torque measurement were performed before after administration. A large number individual fibers dissected from samples (pre‐administration: n = 165, post‐administration: 177). Results: Maximal increased (∼13%), whereas both type 1 2A had...
ABSTRACT INTRODUCTION Human skeletal muscle displays an epigenetic memory of resistance exercise induced by hypertrophy. It is unknown, however, whether high-intensity interval training (HIIT) also evokes memory. This study employed repeated intervention interspersed with a detraining period to assess HIIT. METHODS Twenty healthy subjects (25±5yrs) completed two HIIT interventions (training and retraining) lasting 2 months, separated 3 months detraining. Measurements at baseline, after...
An ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from first 1500 patients with BTP enrolled this study are presented here. Thirty-two centers involved survey. A diagnosis was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage disease, presence and sites metastases, oncologic treatment,...
The aims were to investigate the plasticity of myosin heavy chain (MHC) phenotype following neuromuscular electrical stimulation (NMES) and assess correlation between MHC isoform distribution muscle fibre conduction velocity (MFCV). 14 men subjected 24 sessions quadriceps NMES. Needle biopsies taken from dominant vastus lateralis tests performed on thigh before after training. NMES significantly increased maximal force by 14.4±19.7% (P=0.02), thickness 10.7±8.6% (P=0.01), MFCV 11.1±3.5%...
PURPOSE A large proportion of patients with cancer suffer from breakthrough pain (BTcP). Several unmet clinical needs concerning BTcP treatment, such as optimal opioid dosages, are being investigated. In this analysis the hypothesis, we explore an unsupervised learning algorithm whether distinct subtypes exist and they can provide new insights into practice. METHODS Partitioning around a k-medoids on data set BTcP, previously collected by Italian Oncologic Pain Survey group, was used to...
The aim of our study was to investigate fiber type distribution and contractile characteristics Latissimus Dorsi muscle (LDM). Samples were collected from 18 young healthy subjects (9 males 9 females) through percutaneous fine needle biopsy. results showed a predominance fast myosin heavy chain isoforms (MyHC) with 42% MyHC 2A 25% 2X, while 1 represented only 33%. unbalance toward even greater in (71%) than females (64%). Fiber partially reflected isoform 28% 1/slow fibers 5% hybrid 1/2A...
The response to resistance training and protein supplementation in the latissimus dorsi muscle (LDM) has never been investigated. We investigated effects of (RT) on mass, strength, fiber characteristics LDM. Eighteen healthy young subjects were randomly assigned a progressive eight-week RT program with normal diet (NP) or high (HP) (NP 0.85 vs. HP 1.8 g protein·kg(-1)·day(-1)). One repetition maximum tests, magnetic resonance imaging for cross-sectional area (CSA), body composition, single...
Abstract: Two formulations of morphine citrate were synthesized: trimorphine citrate, 3(MH)+(C 6 H 5 O 7 ) 3– and sodium 3(MH)+ 3Na+2(C . Four healthy individuals volunteered to undergo electromotive administration the two formulations. Application electric current (2 mA) solutions for 1 h resulted in iontophoretic transcutaneous therapeutic quantities morphine, without deleterious reduction pH drug solutions. a 2–mA 2 combined electrophoretic delivery with increased rates an improved...