A5066627217- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Biomedical Text Mining and Ontologies
- Semantic Web and Ontologies
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Quantum Chromodynamics and Particle Interactions
- Melanoma and MAPK Pathways
- Particle Detector Development and Performance
- Gene expression and cancer classification
- Scientific Computing and Data Management
- Horticultural and Viticultural Research
- Genomic variations and chromosomal abnormalities
- Bioenergy crop production and management
- Infrared Target Detection Methodologies
- Service-Oriented Architecture and Web Services
- Genetic factors in colorectal cancer
- Lysosomal Storage Disorders Research
- Plant Gene Expression Analysis
- Cellular transport and secretion
- interferon and immune responses
- Plant Molecular Biology Research
- Sirtuins and Resveratrol in Medicine
- Cutaneous Melanoma Detection and Management
University of Padua
2005-2022
UCLouvain
2006-2007
GlaxoSmithKline (Italy)
2006
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2005
CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV Large Hadron Collider (LHC). It currently involves more than 2000 physicists from 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle based on its unprecedented collision energy luminosity when it begins operation in 2007.
This report presents the capabilities of CMS experiment to explore rich heavy-ion physics programme offered by CERN Large Hadron Collider (LHC). The collisions lead nuclei at energies , will probe quark and gluon matter unprecedented values energy density. prime goal this research is study fundamental theory strong interaction — Quantum Chromodynamics (QCD) in extreme conditions temperature, density parton momentum fraction (low-x).
In light of ongoing climate changes in wine-growing regions, the selection drought-tolerant rootstocks is becoming a crucial factor for developing sustainable viticulture. this study, M4, new rootstock genotype that shows tolerance to drought, was compared from genomic and transcriptomic point view with less 101.14. The root leaf transcriptome both 101.14 M4 analysed, following exposure progressive drought conditions. Multifactorial analyses indicated stress treatment represents main driving...
Whole genome and exome sequencing are contributing to the extraordinary progress in study of human genetic variants. In this fast developing field, appropriate easily accessible tools required facilitate data analysis.Here we describe QueryOR, a web platform suitable for searching among known candidate genes as well finding novel gene-disease associations. QueryOR combines several innovative features that make it comprehensive, flexible easy use. Instead being designed on specific datasets,...
Lysosomal storage disorders (LSDs) are monogenic diseases, due to accumulation of specific undegraded substrates into lysosomes. LSD diagnosis could take several years because both poor knowledge these diseases and shared clinical features. The diagnostic approach includes evaluations, biochemical tests, genetic analysis the suspected gene. In this study, we evaluated an targeted sequencing panel as a tool capable potentially reverse classic route. 50 genes 230 intronic sequences conserved...
The Gene Ontology Project provides structured controlled vocabularies for molecular biology that can be used the functional annotation of genes and gene products. In a collaboration between (GO) Consortium muscle community, we have made large-scale additions to GO biological process cellular component ontologies. main focus this ontology development work concerns skeletal muscle, with specific consideration given processes contraction, plasticity, development, regeneration, sarcomere...
In mammalian cells, the catabolic activity of dNTP triphosphohydrolase SAMHD1 sets balance and concentration four dNTPs. Deficiency leads to unequally increased pools marked imbalance. Imbalanced increase mutation frequency in cancer but it is not known if SAMHD1-induced imbalance favors accumulation somatic mutations non-transformed cells. Here, we have investigated how fibroblasts from Aicardi-Goutières Syndrome (AGS) patients with mutated react constitutive pool characterized by a huge...
Laboratory protocols in life sciences tend to be written natural language, with negative consequences on repeatability, distribution and automation of scientific experiments. Formalization knowledge is becoming popular science. In the case laboratory two levels formalization are needed: one for entities individuals operations involved another procedures, which can manually or automatically executed. This study aims combine ontologies workflows protocol formalization. A domain specific...
The MITF-E318K variant has been implicated in genetic predisposition to cutaneous melanoma. We addressed the occurrence of and its association with germline status CDKN2A MC1R genes a hospital-based series 248 melanoma patients including cohorts multiple, familial, pediatric, sporadic associated other tumors. Seven carriers were identified, spanning every group except pediatric patients. Three showed mutated CDKN2A, five displayed variants, while carrier revealed no variants. Germline/tumor...
64 Background: At present, the clinical management of resected GC is only based on risk stratification according to AJCC staging. This project evaluates molecular factors formalin-fixed, paraffin-embedded (FFEP) specimens primary tumor radically in an omogeneous group patients considered at poor prognosis by nodal involvement (pN3a/b 7 th edition) and included ITACA-S trial. Methods: Matched pairs tumor-normal FFPE collected from 15 were subjected whole-exome sequencing using TruSeq Exome...