A5079140397- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Circular RNAs in diseases
- Head and Neck Surgical Oncology
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Voice and Speech Disorders
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Trauma Management and Diagnosis
- Meningioma and schwannoma management
- Cancer-related Molecular Pathways
- Advanced MRI Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Colorectal and Anal Carcinomas
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Kunming Medical University
2024-2025
Jiangsu University of Technology
2023
Jiading District Central Hospital
2018-2023
Air Force General Hospital PLA
2023
The University of Texas MD Anderson Cancer Center
2008-2016
The First Affiliated Hospital, Sun Yat-sen University
2014
Sun Yat-sen University
2014
PLA 306 Hospital
2011-2012
The evolution of binary systems consisting an asymptotic giant branch star mass equal to 3 M☉ or 5 and a main-sequence 0.4 0.6 with orbital periods ≳200 days has been followed from the onset through late stages common-envelope phase. Using nested grid technique, three-dimensional hydrodynamical simulations radii ~1 AU indicate that significant fraction envelope gas is unbound (~31% 23% for binaries M☉, respectively) by ends efficiency ejection process ~40%. During intermediate phase,...
Abstract Objective To evaluate the prevalence of vitamin D deficiency in pregnant women and their newborns Beijing, China influence on birth size. Design A cross-sectional study. Setting Data were collected from who delivered during April to May 2010 at 306 Hospital PLA China. Subjects Participants study seventy healthy nulliparous with singleton pregnancies babies full term newborns. Results Severe (25-hydroxyvitamin (25(OH)D) < 25 nmol/l) was detected 54·5 % mothers 46·6 Neither nor had...
Head and neck squamous cell carcinoma (HNSCC) is one of the most heavily immune infiltrated human tumors, having distinct subtypes associated with different molecular characteristics clinical outcomes. The tumor microenvironment (TME) HNSCC which was dominated by tumor-associated macrophages (TAMs) had a relatively inferior prognosis. High levels oxidized low-density lipoprotein receptor 1 (OLR1) expression are more aggressive metastatic in multiple cancers. However, link between OLR1...
The mechanisms distinguishing metabolically healthy from unhealthy phenotypes within the same BMI categories remain unclear. This study aimed to investigate associations between regional fat distribution and in Chinese adults across different categories. cross-sectional involving 11833 aged 20 years older. Covariance analysis, adjusted for age, compared percentage of (trunk, leg, or arm divided by whole-body fat) participants. Trends with number metabolic abnormalities were assessed...
A case of a 60-year-old male patient with thyroid cancer invading the trachea was presented in current study. After initial surgery via sternocleidomastoid muscle (SCM) clavicular periosteal flap for tracheal reconstruction, experienced necrosis. Subsequent debridement and tracheocutaneostomy were performed, followed by successful repair defect using platysma myocutaneous flap. The underscores critical role preserving SCM's integrity to ensure adequate blood supply reduce risk staged...
Background: The treatment of a pharyngocutaneous fistula (PCF) is typically lengthy and arduous process, often causing significant pain for patients. This study aims to introduce new method treating PCF, negative pressure tube drainage (NPTD). Methods: A retrospective was conducted on 43 patients who developed PCF after laryngectomy. Of these, 20 received NPTD, while the remaining 23 were treated with open wound dressing change (OWC). Clinical indicators compared between two groups. Results:...
Objective: To enhance the awareness of diverse manifestations head and neck tuberculosis (HNTB) diagnostic hurdles it poses. Study Design: analyze presentation clinical characteristics HNTB cases. The diagnosis in all cases was established through histopathological examination infected tissue conjunction with medical history, TB-SPOT other complementary TB investigations. Follow-up time 1 to 10 years. Setting: Peking Union Medical College Hospital. Methods: This retrospective study examined...
Abstract The increasing incidence of oral squamous cell carcinoma (OSCC) in young adults has been associated with sexually transmitted infections human papillomavirus (HPV), particularly HPV16. Given the roles p53 tumor suppression and HPV E6 MDM2 oncoproteins degradation, we evaluated HPV16 L1 seropositivity promoter variants to examine their possible associations OSCC risk a case-control study 325 patients 335 cancer-free matched controls. Compared individuals having MDM2-rs2279744 GT or...
A growing body of evidence has suggested that circular RNAs (circRNAs) have crucial functions in the regulation gene expression, and their dysregulation been implicated various types cancers. However, roles circRNAs laryngeal cancer remain largely unknown. This study investigated global changes expression pattern squamous cell carcinoma (LSCC) to identify potential differentially expressed circRNAs.Microarray-based circRNA was determined LSCC paired normal tissues. Pathway analyses genes...
Abstract Background Recent studies have uncovered that the microbiota in patients with head and neck cancers is significantly altered may drive cancer development. However, there limited data to explore unique of laryngeal squamous cell carcinoma (LSCC), little known regarding whether oral can be utilized as an early diagnostic biomarker. Methods Using 16S rRNA gene sequencing, we characterized microbiome rinse tissue samples from 77 LSCC 76 control vocal polyps, then performed bioinformatic...
Forty-five KPC-producing Enterobacteriaceae strains were isolated from multiple departments in a Chinese public hospital 2014 to 2015. Genome sequencing of four representative strains, namely Proteus mirabilis GN2, Serratia marcescens GN26, Morganella morganii GN28, and Klebsiella aerogenes E20, indicated the presence blaKPC-2-carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, pE20-KPC respectively. These genetically closely related one another only previously sequenced plasmid,...
Acne rosacea is a type of chronic dermatosis with the characteristics erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to side effects. Artesunate demonstrated promising therapeutic efficacy high safety margin. HaCaT cells were treated antibacterial peptide LL‑37 simulate caused by Demodex folliculorum (D. folliculorum) infection. Cell Counting kit 8 flow cytometry assays performed measure cellular proliferation, apoptosis, stage cell...
The p53 tumor suppressor protein homolog p73 can be inactivated by oncoprotein E6 of human papillomavirus (HPV). Variation in may alter the interaction between and and, thus, risk for HPV-associated carcinogenesis. It is believed that G4C14-to-A4T14 polymorphism affects function altering gene expression; however, whether also alters HPV type 16 (HPV-16)-associated squamous cell carcinoma oropharynx (SCCOP) unknown.The current case-control study included a case group 188 non-Hispanic white...
Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous which present a wide spectrum of pathological clinical manifestations. Fourteen patients with histologically demonstrated LNEC were collected analyzed retrospectively. The 14 cases classified into 3 subtypes: typical carcinoid in 2, atypical 5, small cell carcinoma 7. mean survival time the this study was 112.5 months (95% CI, 81.5–143.6). Surgeries performed for 2 carcinoid, they alive no evidence recurrence after...