A5012791304- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Screening and Detection
- Evolution and Genetic Dynamics
- melanin and skin pigmentation
- Lung Cancer Research Studies
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Gastrointestinal disorders and treatments
- Gene expression and cancer classification
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Intraperitoneal and Appendiceal Malignancies
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Genomic variations and chromosomal abnormalities
Cedars-Sinai Medical Center
2023-2024
City of Hope
2024
City Of Hope National Medical Center
2021-2022
Memorial Sloan Kettering Cancer Center
2016-2021
University Surgical Associates
2018
Cancer Research Center
2017
Stanford University
2017
Icahn School of Medicine at Mount Sinai
2017
Kettering University
2017
Johns Hopkins Hospital
2016
Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse, among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data 76 untreated from 20 patients and inferred cancer phylogenies breast, colorectal, endometrial, gastric, lung, melanoma, pancreatic, prostate cancers. found that individual patients, a large driver gene mutations common to all metastases. Further...
Previous nomogram models for patients undergoing resection of intraductal papillary mucinous neoplasms (IPMNs) have been relatively small single-institutional series. Our objective was to improve upon these studies by developing and independently validating a new model using large multiinstitutional dataset.IPMNs represent the most common radiographically identifiable precursor lesions pancreatic cancer. They are heterogenous group in which more accurate markers high-grade dysplasia or early...
Surgery is the only curative option for stage I/II pancreatic cancer; nonetheless, most patients will experience a recurrence after surgery and die of their disease. To identify novel opportunities management recurrent cancer, we performed whole-exome or targeted sequencing 10 resected primary cancers matched intrapancreatic recurrences distant metastases. We identified that disease adjuvant first-line platinum therapy corresponds to an increased mutational burden. Recurrent enriched genetic...
Purpose Intraductal papillary mucinous neoplasms ( IPMN s) are radiographically visible precursor lesions of pancreatic cancer. Despite standard criteria for assessing risk, only 18% cysts malignant at resection. Thus, a large number patients undergo unnecessary invasive surgery benign disease. The ability to identify s with low or high risk transforming into cancer would optimize patient selection and improve surgical decision‐making. purpose this study was investigate quantitative CT...
Abstract Background Microarray technology provides a powerful tool for defining gene expression profiles of airway epithelium that lend insight into the pathogenesis human disorders. The focus this study was to establish rigorous quality control parameters ensure microarray assessment is not confounded by experimental artifact. Samples (total n = 223) trachea, large and small were collected fiberoptic bronchoscopy 144 individuals hybridized Affymetrix microarrays. pre- post-chip (QC)...
Objective: In 2015, the American Gastroenterological Association recommended discontinuation of radiographic surveillance after 5 years for patients with stable pancreatic cysts. The current study evaluated yield continued cysts up to and follow up. Methods: A prospectively maintained registry was queried (1995–2016). Patients who initially underwent were divided into those <5 ≥5 Analyses presence cyst growth (>5 mm increase in diameter), cross-over resection, development carcinoma...
Abstract Multiple myeloma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites. To characterize this evolutionary process, we interrogated, whole genome sequencing, 25 samples collected at autopsy from 4 patients with relapsed MM and an additional set 125 exomes 51 patients. Mutational signatures analysis showed how cytotoxic agents introduce hundreds unique mutations each surviving cell, detectable bulk sequencing only cases clonal expansion a single...
Microarrays are frequently used to profile genome-wide copy number (CN) aberrations. While generally robust for detecting CN variants in germline DNA, the methods derive from signal intensity values have been suboptimal when applied cancer genomes. The complexity of genomic aberrations makes it more difficult discriminate between and noise, measuring as a discrete variable does not account tumor heterogeneity. Furthermore, standard normalization approaches detect changes relative overall DNA...
Preliminary work by our group suggested that proteins within the pancreatic cyst fluid (CF) may discriminate degree of IPMN dysplasia. We sought to externally validate these markers and determine whether their inclusion in a preoperative clinical nomogram could increase diagnostic accuracy.IPMN is most common radiographically identifiable precursor cancer; however, timing frequency its malignant progression are unknown, there currently no reliable tests can grade dysplasia IPMN.Clinical...
BackgroundPancreatic adenocarcinoma (PDAC) is a lethal cancer with <7% of patients surviving past 5 years.T cell immunity has been linked to the exceptional outcome rare long-term survivors but antigens are unknown.Methods To identify T in PDAC survivors, we assembled largest cohorts stage-matched short [n=68, median overall survival (OS) 0.8y] and (n=82, OS 6y).To enable antigen discovery, performed combined analysis whole exome sequencing, neoantigen prediction, receptor (TCR) Vβ-chain...
BackgroundThe role of preoperative stereotactic body radiation therapy (SBRT) in pancreatic cancer is controversial and questions regarding the optimal dose treatment field remain. To better inform future investigations SBRT fields, we evaluated patterns failure patients with borderline resectable/locally advanced (BR/LAPC) after chemotherapy who underwent surgical resection.MethodsWe performed a single institution retrospective review consecutive treated from September 2017 to January 2022...
Although the pancreatic cancer genome has been described, it not explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify genomic features PDAC in context evolutionary metrics doing so have identified a novel prognostic biomarker.