A5030463712- Immune Cell Function and Interaction
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- interferon and immune responses
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Chemistry and Chemical Engineering
- Escherichia coli research studies
- Probiotics and Fermented Foods
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Neonatal Respiratory Health Research
- Nanoparticles: synthesis and applications
- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Polymer composites and self-healing
- Synthesis and Biological Evaluation
- Single-cell and spatial transcriptomics
- Cancer-related gene regulation
- Bioactive Compounds and Antitumor Agents
- Gut microbiota and health
University of Debrecen
2012-2024
Prior exposure to microenvironmental signals could fundamentally change the response of macrophages subsequent stimuli. It is believed that T helper-2 (Th2)-cell-type cytokine interleukin-4 (IL-4) and Toll-like receptor (TLR) ligand-activated transcriptional programs mutually antagonize each other, no remarkable convergence has been identified between them. In contrast, here, we show IL-4-polarized established a hyperinflammatory gene expression program upon lipopolysaccharide (LPS)...
The vertebrate gut symbiont Lactobacillus reuteri exhibits strain-specific adhesion and health-promoting properties. Here, we investigated the role of mucus adhesins, CmbA MUB upon interaction with L. strains ATCC PTA 6475 53608 in human monocyte-derived DCs (moDCs). We showed that adhesins increased capacity to interact moDCs promoted phagocytosis. Our data also suggest mediate anti- pro-inflammatory effects by induction interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), IL-1ß,...
Dendritic cells (DCs) are considered as the main coordinators of both mucosal and systemic immune responses thus playing a determining role in shaping outcome effector cell responses. However, it is still uncovered how primary human monocyte-derived DC populations (moDC) drive polarization helper T (Th) presence commensal bacteria harboring unique immunomodulatory properties. Furthermore, individual members gut microbiota have potential to modulate shape immunogenicity differentiating moDCs...
Abstract Identification of the CD1a+ moDC as an inflammatory subset with specialized activation RLR and associated cytokine functional activities. Cytosolic RIG-I-like helicases (RLR) are PRRs involved in type I IFN production antiviral immunity. This study focuses to comparison expression, function, signaling cascades previously identified CD14−DC-SIGN+PPARγlowCD1a+ CD14lowDC-SIGN+PPARγhighCD1a− human subsets. Our results revealed that expression genes proteins well activity coupled...
To detect replicating viruses, dendritic cells (DCs) utilize cytoplasmic retinoic acid inducible gene-(RIG) I-like receptors (RLRs), which play an essential role in the subsequent activation of antiviral immune responses. In this study, we aimed to explore mammalian target rapamycin (mTOR) regulation RLR-triggered effector functions human monocyte-derived DCs (moDCs) and plasmacytoid (pDCs). Our results show that RLR stimulation increased phosphorylation mTOR complex (mTORC) 1 mTORC2...
Introduction Macrophages significantly contribute to the regulation of vessel formation under physiological and pathological conditions. Although angiogenesis-regulating role alternatively polarized macrophages is quite controversial, a growing number evidence shows that they can participate in later phases angiogenesis, including sprouting remodeling or regression. However, epigenetic transcriptional regulatory mechanisms controlling this angiogenesis-modulating program are not fully...
Mesenchymal stromal cell-like (MSCl) cells generated from human embryonic stem are considered to be an eligible cell line model the immunomodulatory behavior of mesenchymal (MSCs) in vitro. Dendritic (DCs) essential players maintenance and restoration sensitive balance between tolerance immunity. Here, effects MSCl on vitro differentiation monocytes into DCs were investigated. promote CTLA-4 expressing via production all-trans retinoic acid (ATRA) functioning as a ligand RARα, key nuclear...
Introduction: In this work we selected components, developed technology and studied a number of parameters polymer nanocomposite materials, remembering that the material would have high optical good mechanical characteristics, sorption ability in order to ensure value signal for short time while maintaining initial geometric shape. addition, if is used medicine biology (biocompatible or biocidal materials creation sensor based on it), must be non-toxic and/or biocompatible. We study...
Alveolar macrophages (AMs) act as gatekeepers of the lung's immune responses, serving essential roles in recognizing and eliminating pathogens. The transcription factor (TF) Early Growth Response 2 (EGR2) has been recently described required for mature AMs mice; however, its mechanisms action have not explored. Here, we identified EGR2 an epigenomic regulator likely direct proximal transcriptional activator using approaches (RNA-sequencing, ATAC-sequencing, CUT&RUN). predicted targets...