A5001561118- Trypanosoma species research and implications
- Malaria Research and Control
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Healthcare Systems and Practices
- Health, Medicine and Society
- Parasites and Host Interactions
- Global Maternal and Child Health
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Travel-related health issues
- Pharmacovigilance and Adverse Drug Reactions
- Complement system in diseases
- Insect Pest Control Strategies
- Aging, Elder Care, and Social Issues
- Synthesis and Biological Evaluation
- Child Nutrition and Water Access
- Cardiovascular Issues in Pregnancy
- COVID-19 Impact on Reproduction
- Biochemical and Molecular Research
- Parasitic Diseases Research and Treatment
- Agriculture and Rural Development Research
- Public Health and Social Inequalities
- HIV/AIDS Impact and Responses
- Pharmacological Effects and Toxicity Studies
Nantes Université
2015-2025
Université Paris Cité
2009-2015
Institut de Recherche pour le Développement
2006-2015
Mère et Enfant en Milieu Tropical
2009-2015
Délégation Paris 5
2011-2014
Sorbonne Paris Cité
2012-2014
Institut de Recherche pour le Développement
2002-2011
Hôpital Tenon
2008
Sorbonne Université
2008
Institut de Recherche pour le Développement
2006-2007
Background Trypanosoma cruzi has been classified into six Discrete Typing Units (DTUs), designated as TcI–TcVI. In order to effectively use this standardized nomenclature, a reproducible genotyping strategy is imperative. Several typing schemes have developed with variable levels of complexity, selectivity and analytical sensitivity. Most them can be only applied cultured stocks. context, we aimed develop multiplex Real-Time PCR method identify the T. DTUs using TaqMan probes (MTq-PCR)....
Journal Article Lutzomyia evansi, an alternate vector of Leishmania chagasi in a Colombian focus visceral leishmaniasis Get access B.L. Travi, Travi 1Centro International de Investigacions Médicas, Apartado Aéreo 5390, Cali, Colombia Search for other works by this author on: Oxford Academic PubMed Google Scholar I.D. Vélez, Vélez 2Sección Parasitología, Facultad Medicina, Universidad Antioquia, 1226, Medellín, L. Brutus, Brutus I. Segura, Segura C. Jaramillo, Jaramillo J. Montoya...
Vector control has led to a drastic decrease in the prevalence of acquired Chagas disease Latin America, thus redirecting attention congenital disease. We report results longitudinal study 359 pregnant women Yacuiba southern Bolivia, whom 147 (40.9%) were infected with Trypanosoma cruzi , evaluate relationship between patency period parasitemia and risk infection. Maternal infection was assessed by using T. -specific serologic tests, mothers newborns diagnosed microscopic examination blood...
A controlled randomized trial of antihelminthic treatment was undertaken in 1996-1997 a rural area Madagascar where populations were simultaneously infected with Ascaris lumbricoides and Plasmodium falciparum. Levamisole administered bimonthly to 164 subjects, on family basis, whereas 186 controls. While levamisole proved be highly effective reducing egg loads the treated group (P < 10(-3) at all visits), subjects more than 5 years age, had significant increase their P. falciparum densities...
To better understand the factors involved in maternal-fetal transmission of Trypanosoma cruzi, we compared DNA levels-obtained by use quantitative real-time PCR and parasitic genotypes determined amplification followed hybridization-in Bolivian mothers their congenitally infected newborns. Mothers neonates displayed markedly different levels, as most maternal estimated parasitemias (> 90%) were < 10 parasites/mL, whereas those 76% newborns > 1,000 parasites/mL. Comparison T. cruzi TcII...
This study aims to typify the Trypanosoma cruzi (sub)lineage(s) in umbilical cord blood of congenitally infected Bolivian newborns, using PCR amplifications "Region Markers", mini-exon or kDNA fragments followed by hybridization sequencing. New probes were also designed distinguish three variants within TcIId sublineage. The IIb, IId, IIe T. sublineages, as well different IId sublineage, detected neonates, whereas mixed infections not found. frequencies sublineage similar neonates (95.1%)...
A controlled randomized trial of anti-helminthic treatment was undertaken in 1996-1997 a rural area Madagascar where populations were simultaneously infected with Ascaris lumbricoides, Plasmodium falciparum, and Schistosoma mansoni. Levamisole administered bimonthly to 107 subjects, whereas 105 controls. highly effective reducing egg loads the treated group (P < 10(-3) at all visits), it had no effect on schistosomiasis. Subjects 5-14 years age, levamisole, significant increase their P....
Summary Objective To determine the risk factors of congenital Chagas disease and consequences in newborns. Methods Study 2712 pregnant women 2742 newborns Yacuiba, south Bolivia. infection was determined serologically mothers parasitologically Consequences were assessed clinically. Results The prevalence 42.2%. Congenital transmission estimated at 6% infected leading to an incidence rate 2.6% among Main mothers’ seropositivity maternal Trypanosoma cruzi parasitaemia. Parity higher than...
Summary Background Comparing two surveys performed in Bolivia 1992–1994 and 1999–2001, we reported a significant decrease the proportions of severe mortal forms congenital Chagas disease. This might be due to reduction vectorial density (VD) maternal residence area, raising question possible causal relationship between such VD, parasitaemia prognosis infection with Trypanosoma cruzi. Method Comparisons haematological parasitological data obtained from Bolivian mothers infected T. cruzi,...
We evaluated the prevalence of Chagas disease using a rapid screening test (Chagas Stat-Pak), confirmed by ELISA, in Caraparí, village 9000 inhabitants southern Bolivian Chaco. The Trypanosoma cruzi was estimated sample 995 people. adjusted on age 51.2% and proportionally related to age. also observed very significant cline from south north locality, where ranged 40 80%. In children younger than 11 years, 21.5%, which importance residual vector transmission despite several years control....
Objective To compare the drop of Chagas antibody titres between non-infected and congenitally infected newborns treated by two doses benznidazole, aiming at evaluating recovery time giving recommendations regarding serological criteria recovery. Methods During a clinical trial, Trypanosoma cruzi measured ELISA tests was followed during first year life in with different benznidazole compared to T. non-parasitaemic newborns. Confirmation given negative tests: Stat-Pak® (CSP)...
Abstract Plasmodium vivax is a major cause of illness in areas with low transmission malaria Latin America, Asia, and the Horn Africa. However, pregnancy-associated remains poorly characterized such areas. Using hospital-based survey women giving birth an antenatal survey, we assessed prevalence rates spp. infections pregnant Bolivia, evaluated consequences during pregnancy on health mothers newborns. P. infection was detected 7.9% attending visits, placental occurred 2.8% deliveries; these...
Polymorphism at nine microsatellite loci was examined to assess the level of genetic differentiation between four Anopheles arabiensis populations from Senegal, high plateau Madagascar, and Reunion Mauritius islands. Eight showed great polymorphism (2-16 alleles/locus) significant revealed all by F- R-statistics, with Fst estimates ranging 0.080 0.215 equivalent Rst values 0.022 0.300. These amounts are discussed in relation geographic distance including large bodies water, history mosquito...
To compare the results of an immunochromatographic test performed on whole blood, Chagas Stat-Pak, with those ELISA using recombinant antigens.We tested 995 subjects a rural population all ages in south Bolivia, 459 pregnant women same and 1030 urban giving birth from east Bolivia.The sensitivity CSP for entire studied (n = 2484) was 94.73% [93.35-96.10]; specificity 97.33% [96.50-98.15]. However, differed significantly between birthing women, which could be attributed either to differences...
Summary Objective To demonstrate the feasibility of a house‐to‐house screening system used for congenital Chagas disease in rural areas based on an active search pregnant women and newborns their homes addition to passive case detection health facilities. Methods Exploratory phase conducted by research team followed operational period coordinated municipal service. A blood sample was taken serological parasitological tests Trypanosoma cruzi from who were searching antenatal care or visited...
A randomised, unblinded, clinical trial comparing two benznidazole regimens for congenital Chagas disease was carried out to determine whether simplification and reduction in the length of treatment could lead better compliance. This study conducted Santa Cruz, Bolivia. Serological screening pregnant women, parasites were sought blood newborns from seropositive mothers. Infected infants randomly assigned groups. Recovery assessed by parasite seeking at 1 month 2 months as well serological...
ABSTRACT The immunological consequences of pregnancy-associated malaria (PAM) due to Plasmodium falciparum have been extensively investigated in cross-sectional studies conducted at delivery, but there very few longitudinal changes PAM during pregnancy. We a prospective study Benin investigate the associated with groups 131 and 111 women inclusion second trimester respectively. Infected were identified by standard microscopic examinations blood smears quantitative PCR (qPCR) assays matched...
A seroprevalence survey of Trypanosoma cruzi was carried out in two areas South Bolivia. Triatoma infestans, the main vector Tryp. cruzi, abundant first area, but absent second one. Titration antibodies children aged 6-24 months and their mothers. The Chagas' disease significantly higher area with vector, also high area. infection under 2 years old could be linked to congenital transmission parasites during pregnancy and/or delivery, despite active control both areas.
Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces causes inflammation and pathology. Knowledge the profiles immune cells associated with physiopathology pregnancy-associated malaria (PAM) is scarce. We conducted a longitudinal, prospective study, both Benin Tanzania, including ∼1000 pregnant women each site systematic follow-up at scheduled antenatal visits until delivery. used ex vivo flow cytometry to identify peripheral blood mononuclear cell...