A5002130807- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cystic Fibrosis Research Advances
- Antimicrobial Peptides and Activities
- Color Science and Applications
- Microbial Metabolic Engineering and Bioproduction
- Synthesis and Characterization of Heterocyclic Compounds
- Electrochemical Analysis and Applications
- Pharmacological Effects of Medicinal Plants
- RNA regulation and disease
- Dye analysis and toxicity
- CRISPR and Genetic Engineering
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
- Inhalation and Respiratory Drug Delivery
- Microbial Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- Antimicrobial agents and applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric health and respiratory diseases
- Drug Transport and Resistance Mechanisms
- Enzyme Catalysis and Immobilization
Laboratoire de Génie Chimique
2015-2023
Université Toulouse III - Paul Sabatier
2005-2022
Université de Toulouse
2009-2022
Institut National Polytechnique de Toulouse
2014-2022
Centre National de la Recherche Scientifique
2022
Institut de Recherche pour le Développement
2009
Pharmacochimie et Pharmacologie pour le Développement
2009
Laboratoire de Chimie
2006
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry
2005
Unilever (United Kingdom)
2005
Pseudomonas aeruginosa plays an important role in chronic lung infections among patients with cystic fibrosis (CF) through its ability to form antibiotic-resistant biofilms. In P. aeruginosa, biofilm development and the production of several virulence factors are mainly regulated by rhl las quorum-sensing (QS) systems, which controlled two N-acyl-homoserine lactone signal molecules. a previous study, we discovered original QS inhibitor, N-(2-pyrimidyl)butanamide, called C11, based on...
A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ pyrimethamine cross-resistant (K1) strains Plasmodium falciparum (P.f.), as well cytotoxic concentration (CC50) on MCF7 KB human tumor cell lines. Compound 26 (5-methoxy-indolone-N-oxide analogue) had the most potent antiplasmodial (<3 nM FcB1 = 1.7 3D7) a very satisfactory selectivity index (CC50...
The waterborne pathogen Legionella pneumophila grows as a biofilm, freely or inside amoebae. Cyclic-di-GMP (c-di-GMP), bacterial second messenger frequently implicated in biofilm formation, is synthesized and degraded by diguanylate cyclases (DGCs) phosphodiesterases (PDEs), respectively. To characterize the c-di-GMP-metabolizing enzymes involved L. regulation, consequences on formation c-di-GMP concentration of each corresponding gene inactivation were assessed Lens strain. results showed...
Quaternary ammonium salts (chloride, bromide and iodide; QUATs) with n-alkyl chain lengths between C8 C18 have been synthesized under optimized experimental conditions. These compounds were tested in vitro for antimicrobial activity against representative bacterial strains (Staphylococcus aureus CIP 4.83, Enterococcus hirae 5855, Pseudomonas aeruginosa 82118, Escherichia coli 53126, Mycobacterium smegmatis 7326) fungal species (Aspergillus niger ATCC 16404, Candida albicans IP 118079,...
Biofilm formation is considered a major cause of therapeutic failure because bacteria in biofilms have higher protection against antimicrobials. Thus, biofilm-related infections are extremely challenging to treat and pose concerns for public health, along with huge economic impacts. Pseudomonas aeruginosa, particular, “critical priority” pathogen, responsible severe infections, especially cystic fibrosis patients its capacity form resistant biofilms. Therefore, new approaches needed complete...
The guanabenz derivative Sephin1 has recently been proposed to increase the levels of translation initiation factor 2 (eIF2α) phosphorylation by inhibiting dephosphorylation protein phosphatase 1 - GADD34 (PPP1R15A) complex. As eIF2α kinase R (PKR) is a prominent cellular antiviral pathway, we evaluated consequences treatment on virus replication. Our results provide evidence that downregulates replication human respiratory syncytial virus, measles adenovirus 5 enterovirus D68,...
The discovery of quorum sensing (QS) communication systems regulating bacterial virulence has afforded a novel opportunity for controlling infectious bacteria by interfering with QS. Pseudomonas aeruginosa is an example opportunistic human pathogen which N-acyl homoserine lactone (AHL)-related compounds have been described as potent inhibitors biofilm formation and factors, given their similarity to the natural QS autoinducers (AHLs). Our purpose was design analogs N-butanoyl-L-homoserine...
Abstract Two series of chlorinated benzhydryl imidazole and triazole derivatives were synthesized tested in vitro against representative strains potent pathogenic bacteria ( Staphylococcus aureus CIP 4.83 , Escherichia hirae 5855, Pseudomonas aeruginosa 82118, coli 53126) fungi Aspergillus niger IP 1431.83 Candida albicans 48.72 krusei 208.52 Trichophython rubrum 1657.86). Most these compounds devoid any antimicrobial activity, but several them inhibited T. with MIC values the range 0.125 to...
The degradation of dyes is frequently initiated by one-electron oxidation or reduction; however, relatively little known about the initially formed radicals. Acid Green 25 (AG25), Crystal Violet (CVI), Methylene Blue (MB), and Orange 7 (AO7), representing paradigms four types commercial organic dyes, were therefore investigated in terms their redox behavior. Their potentials MeCN buffered aqueous solutions determined cyclic voltammetry. structures reduced oxidized established EPR...
Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia are notorious pathogens known for their ability to form resilient biofilms, particularly within the lung environment of cystic fibrosis (CF) patients. The heightened concentration NaCl, prevalent in airway liquid CF patients' lungs, has been identified as a factor that promotes growth osmotolerant bacteria like S. aureus dampens host antibacterial defenses, thereby fostering favorable conditions infections. In this...