A5066162856- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Mycobacterium research and diagnosis
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 detection and testing
- Diagnosis and treatment of tuberculosis
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Vaccine Coverage and Hesitancy
- CAR-T cell therapy research
- Bacillus and Francisella bacterial research
- Virology and Viral Diseases
- Immune Cell Function and Interaction
International Centre for Diarrhoeal Disease Research
2022-2024
University of Dhaka
2016-2024
Kumamoto University
2019
BackgroundAccurate quantitation of immune markers is crucial for ensuring reliable assessment vaccine efficacy against infectious diseases. This study was designed to confirm standardised performance SARS-CoV-2 assays used evaluate COVID-19 candidates at the initial seven laboratories (in North America, Europe, and Asia) Coalition Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN).MethodsThree ELISAs (pre-spike protein, receptor binding domain, nucleocapsid), a...
SARS-CoV-2 has been highly susceptible to mutations since its emergence in Wuhan, China, and subsequent propagation due containing an RNA as genome. The of variants with improved transmissibility still poses a grave threat global health. spike protein mutation is mainly responsible for higher risk severity. This study retrieved structural nonstructural proteins (NSPs) sequences from several geographic locations, including Africa, Asia, Europe, Oceania, North South America. First, multiple...
The adaptive immune response is a crucial component of the protective immunity against SARS-CoV-2, generated after infection or vaccination.We studied antibody titers, neutralizing antibodies and cellular responses to four different COVID-19 vaccines, namely Pfizer-BioNTech, Moderna Spikevax, AstraZeneca Sinopharm vaccines in Bangladeshi population (n = 1780).mRNA (14,655 ± 11.3) Pfizer (13,772 11.5) elicited significantly higher anti-Spike (S) titers compared Adenovector vaccine (2443 12.8)...
Dengue outbreak is one of the concerning issues in Bangladesh due to annual with alarming number death and infection. However, there no effective antiviral drug available treat dengue-infected patients. This study evaluated screened candidates against dengue virus serotype 3 (DENV-3) through viroinformatics-based analyses. Since 2017, DENV-3 has been predominant Bangladesh. We selected non-structural proteins DENV-3, named NS3, NS4A, NS5, as targets. Protein modeling validation were...
Nipah virus (NiV) is an emerging zoonotic causing outbreaks of encephalitis and respiratory illnesses in humans, with high mortality. NiV considered endemic Bangladesh Southeast Asia. There are no licensed vaccines against NiV. This study aimed at predicting a dual-antigen multi-epitope subunit chimeric vaccine surface-glycoproteins G F Targeted proteins were subjected to immunoinformatics analyses predict antigenic B-cell T-cell epitopes. The proposed designs implemented based on the...
For an effective control of tuberculosis, rapid detection multidrug resistant tuberculosis (MDR-TB) is necessary. Therefore, we developed a modified nested multiplex allele-specific polymerase chain reaction (MAS-PCR) method that enables MDR-TB directly from sputum samples. The efficacy this was evaluated using 79 samples collected suspected patients. performance MAS-PCR compared with other methods like drug susceptibility testing (DST) and DNA sequencing. As rifampicin (RIF) resistance...
Epidemiological data of specific respiratory pathogens from the pre-COVID-19 period are essential to determine effects COVID-19 pandemic on other infections. In this study, we revealed molecular epidemiology syncytial virus (RSV) among children in Bangladesh. We tested 3170 samples collected 2008 2012 for a panel viruses; RSV, human metapneumovirus (hMPV), parainfluenza viruses (hPIV) 1, 2, 3, and adenovirus. Five hundred fifty-five (17.5 %) were positive including 2.5% having co-infections...
Background and Objectives: Rifampicin (RIF) isoniazid (INH), two most potent antibiotics, are prescribed to cure tuberculosis. Mycobacterium tuberculosis, the causative agent of multidrug-resistant tuberculosis (MDR-TB), is resistant these first-line drugs. Here, molecular techniques were demonstrated such as PCR sequencing-based GeneXpert assay for rapidly identifying MDR-TB. Materials Methods: Pulmonary samples (sputum) collected from 55 MDR-TB suspected patients Na- tional Tuberculosis...
Cell-to-cell spread of HIV permits ongoing viral replication in the presence antiretroviral therapy and is suggested to be a major contributor sexual transmission by mucosal routes. Fusion inhibitors that prevent entry have been developed, but their clinical applications limited weak antiviral activity, short half-life, low genetic barrier development resistance. We examined inhibitory activities series single-chain variable fragments (scFvs) targeting V3 CD4i epitopes against both cell-free...
Background: Accurate quantitation of immune markers is critical for ensuring reliable assessment vaccines efficacy against infectious diseases. This report presents the standardization and harmonization test results SARS-CoV-2 assays amongst initial seven laboratories (North America, Europe Asia) Coalition Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN) used to support evaluation COVID-19 vaccine candidates.Methods: Three ELISA (Spike, Receptor Binding Domain...