A5027345279- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- SARS-CoV-2 detection and testing
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Pharmacological Effects and Assays
- Liver Disease Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Veterinary Equine Medical Research
- Fibroblast Growth Factor Research
- Pain Mechanisms and Treatments
- Biosimilars and Bioanalytical Methods
- Neurobiology and Insect Physiology Research
Montreal Clinical Research Institute
2019-2024
Nexen (Canada)
2024
Q2 Solutions (United Kingdom)
2023
Université de Montréal
2019
Significance The liver plays crucial roles in the control of glucose homeostasis during fast-feeding cycle. It responds to insulin and glucagon either store or provide other organs. Insulin resistance is a hallmark metabolic diseases such as type 2 diabetes nonalcoholic fatty disease. Associations have been made between low hepatic levels peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A) resistance, but underlying mechanisms are elusive. We show that PGC1A controls...
BackgroundAccurate quantitation of immune markers is crucial for ensuring reliable assessment vaccine efficacy against infectious diseases. This study was designed to confirm standardised performance SARS-CoV-2 assays used evaluate COVID-19 candidates at the initial seven laboratories (in North America, Europe, and Asia) Coalition Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN).MethodsThree ELISAs (pre-spike protein, receptor binding domain, nucleocapsid), a...
To date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. convert data each clinical assay to international standard units, WHO and CEPI generated by Medicines Healthcare products Regulatory Agency were run in multiple facilities determine conversion factor for assay. Reporting results units advances global understanding immunity efficacy, enhancing quality, reliability, utility data.
Spinal cord dorsal horn inhibition is critical to the processing of sensory inputs, and its impairment leads mechanical allodynia. How this decreased occurs whether restoration alleviates allodynic pain are poorly understood. Here, we show that a step in loss inhibitory tone change firing pattern parvalbumin (PV)-expressing neurons (PVNs). Our results PV, calcium-binding protein, controls activity PVNs by enabling them sustain high-frequency tonic patterns. Upon nerve injury, transition...
Abstract The nervous system processes sensory information by relying on the precise coordination of neuronal networks and their specific synaptic firing patterns. In spinal cord, disturbances to pattern tonic parvalbumin (PV)-expressing inhibitory interneuron (PV neurons) disrupt ability dorsal horn integrate touch may result in pathological phenotypes. protein (PVp) is a calcium (Ca 2+ )-binding that buffers accumulation Ca following train action potential allow for firing. Here, we find...
Background: Accurate quantitation of immune markers is critical for ensuring reliable assessment vaccines efficacy against infectious diseases. This report presents the standardization and harmonization test results SARS-CoV-2 assays amongst initial seven laboratories (North America, Europe Asia) Coalition Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN) used to support evaluation COVID-19 vaccine candidates.Methods: Three ELISA (Spike, Receptor Binding Domain...