A5074693708- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Oral microbiology and periodontitis research
University of North Carolina at Chapel Hill
2022-2023
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop post-acute sequelae severe acute respiratory syndrome 2 (SARS-CoV-2) (PASC), but the mechanistic basis PASC-associated lung abnormalities suffers a lack longitudinal tissue samples. The mouse-adapted SARS-CoV-2 strain MA10 produces an distress in mice similar to humans. To investigate PASC pathogenesis, studies MA10-infected were extended clinical recovery phases. At 15 120 days after virus clearance,...
Abstract The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others implicated in enhanced viral replication more severe Current tetravalent vaccines contain live attenuated formulated to theoretically induce balanced protective immunity. Among the number of candidates clinical trials, only Dengvaxia licensed for use DENV seropositive individuals. To...
COVID-19 survivors develop post-acute sequelae of SARS-CoV-2 (PASC), but the mechanistic basis PASC-associated lung abnormalities suffers from a lack longitudinal samples. Mouse-adapted MA10 produces an acute respiratory distress syndrome (ARDS) in mice similar to humans. To investigate PASC pathogenesis, studies MA10-infected were extended disease through clinical recovery. At 15-120 days post-virus clearance, histologic evaluation identified subpleural lesions containing collagen,...
Abstract Background Inflammatory bowel disease (IBD) is a multifactorial disorder characterized by chronic gastrointestinal (GI) inflammation. In clinical practice, physicians urgently need biomarkers to monitor changes in mucosal manage treatment. Non-invasive tools such as fecal could allow for frequent monitoring of activity and may reflect inflammation the entire GI tract. Towards identification novel non-invasive biomarkers, we performed comprehensive, unbiased, analysis human proteome...