A5083383348- Chronic Lymphocytic Leukemia Research
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Dietary Effects on Health
- PI3K/AKT/mTOR signaling in cancer
- ATP Synthase and ATPases Research
- Mathematical Biology Tumor Growth
- Spaceflight effects on biology
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Evolution and Genetic Dynamics
- Bioinformatics and Genomic Networks
- Pharmacological Effects of Natural Compounds
IFOM
2022-2024
University of Turin
2018-2023
Immunotherapy is improving the prognosis and survival of cancer patients, but despite encouraging outcomes in different cancers, majority tumors are resistant to it, immunotherapy combinations often accompanied by severe side effects. Here, we show that a periodic fasting-mimicking diet (FMD) can act on tumor microenvironment increase efficacy (anti-PD-L1 anti-OX40) against poorly immunogenic triple-negative breast (TNBCs) expanding early exhausted effector T cells, switching metabolism from...
Abstract Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically immunologically cancer patients. Here, we reported on the outcome two patients chronic lymphocytic leukemia (CLL) investigated effects fasting CLL models. Fasting-mimicking conditions murine had mild cytotoxic effects, which resulted apoptosis activation mediated part by lowered...
HSP90 is secreted by cancer cells into the extracellular milieu, where it exerts protumoral activities activating substrate proteins and triggering autocrine signals through cell surface receptors. Emerging evidence indicates that co-chaperones are also may direct activities. In this study, we found co-chaperone Morgana released and, in association with HSP90, induces migration TLR2, TLR4, LRP1. syngeneic mouse models, a mAb targeting activity reduced primary tumor growth via...
Cancers feature substantial intratumoral heterogeneity of genetic and phenotypically distinct lineages. Although interactions between coexisting lineages are emerging as a potential contributor to tumor evolution, the extent nature these remain largely unknown. We postulated that tumors develop ecological sustain diversity facilitate metastasis. Using combination fluorescent barcoding, mathematical modeling, metabolic analysis, in vivo models, we show Allee effect, i.e., growth dependency on...
<p>Supplementary Data</p>
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<p>SFigure6</p>
<div>Abstract<p>Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically immunologically cancer patients. Here, we reported on the outcome two patients chronic lymphocytic leukemia (CLL) investigated effects fasting CLL models. Fasting-mimicking conditions murine had mild cytotoxic effects, which resulted apoptosis activation...
<p>Supplementary Data - Table 1</p>
<p>SFigure2</p>
<p>SFigure5</p>
<p>SFigure1</p>
<p>SFigure5</p>
<p>SFigure2</p>
<p>SFigure4</p>
<p>SFigure7</p>
<p>Supplementary Data</p>
<p>SFigure6</p>
<p>SFigure4</p>
<div>Abstract<p>Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically immunologically cancer patients. Here, we reported on the outcome two patients chronic lymphocytic leukemia (CLL) investigated effects fasting CLL models. Fasting-mimicking conditions murine had mild cytotoxic effects, which resulted apoptosis activation...
<p>SFigure3</p>
<p>SFigure1</p>
<p>Supplementary Data - Table 1</p>
<p>SFigure3</p>
<div>Abstract<p>HSP90 is secreted by cancer cells into the extracellular milieu, where it exerts protumoral activities activating substrate proteins and triggering autocrine signals through cell surface receptors. Emerging evidence indicates that HSP90 co-chaperones are also may direct activities. In this study, we found co-chaperone Morgana released and, in association with HSP90, induces migration TLR2, TLR4, LRP1. syngeneic mouse models, a mAb targeting activity reduced...