A5086503175- Chronic Lymphocytic Leukemia Research
- Dietary Effects on Health
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Prion Diseases and Protein Misfolding
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- Advanced Breast Cancer Therapies
- Management, Economics, and Public Policy
- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Adipose Tissue and Metabolism
- Mathematical Biology Tumor Growth
- Marketing and Advertising Strategies
- Evolution and Genetic Dynamics
- Metabolomics and Mass Spectrometry Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Diverse academic and cultural studies
IFOM
2020-2024
University of Tübingen
2022
Hertie Institute for Clinical Brain Research
2022
University of Milan
2020-2021
Metastatic tumors remain lethal due to primary/acquired resistance therapy or cancer stem cell (CSC)-mediated repopulation. We show that a fasting-mimicking diet (FMD) activates starvation escape pathways in triple-negative breast (TNBC) cells, which can be identified and targeted by drugs. In CSCs, FMD lowers glucose-dependent protein kinase A signaling stemness markers reduce number increase mouse survival. Accordingly, metastatic TNBC patients with lower glycemia survive longer than those...
Abstract Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically immunologically cancer patients. Here, we reported on the outcome two patients chronic lymphocytic leukemia (CLL) investigated effects fasting CLL models. Fasting-mimicking conditions murine had mild cytotoxic effects, which resulted apoptosis activation mediated part by lowered...
Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but long presymptomatic phase and poor correlation between clinical symptoms remain puzzling. To elucidate dependency downstream pathologies on Aβ, we analyzed trajectories cerebral accumulation, seeding activity, neurofilament light chain (NfL) CSF (a biomarker neurodegeneration) Aβ-precursor protein transgenic mice. We find that increases linearly until it reaches an apparent plateau at late age,...
Severe calorie restriction, in the form of cyclic fasting or fasting-mimicking diets (FMDs), boosts antitumor activity cytotoxic chemotherapy mouse models triple-negative breast cancer (TNBC). This effect is mostly mediated by fasting/FMD-induced reduction plasma glucose concentration and a boost immunity. However, clinical evidence that FMD may impact on outcomes advanced TNBC (aTNBC) patients lacking. We compared overall survival (OS) 14 aTNBC receiving first-line carboplatin-gemcitabine...
Cancers feature substantial intratumoral heterogeneity of genetic and phenotypically distinct lineages. Although interactions between coexisting lineages are emerging as a potential contributor to tumor evolution, the extent nature these remain largely unknown. We postulated that tumors develop ecological sustain diversity facilitate metastasis. Using combination fluorescent barcoding, mathematical modeling, metabolic analysis, in vivo models, we show Allee effect, i.e., growth dependency on...
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<div>Abstract<p>Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically immunologically cancer patients. Here, we reported on the outcome two patients chronic lymphocytic leukemia (CLL) investigated effects fasting CLL models. Fasting-mimicking conditions murine had mild cytotoxic effects, which resulted apoptosis activation...
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