A5041524529- Anodic Oxide Films and Nanostructures
- Thyroid Cancer Diagnosis and Treatment
- Semiconductor materials and devices
- Cancer Immunotherapy and Biomarkers
- Molecular Junctions and Nanostructures
- Cancer-related Molecular Pathways
- Nanowire Synthesis and Applications
- Force Microscopy Techniques and Applications
- Ga2O3 and related materials
- Organic and Molecular Conductors Research
- Catalytic Processes in Materials Science
- Cancer Mechanisms and Therapy
- Surface and Thin Film Phenomena
- Bioinformatics and Genomic Networks
- Electronic and Structural Properties of Oxides
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Nanofabrication and Lithography Techniques
- Mesoporous Materials and Catalysis
- Cellular Automata and Applications
- Cholesterol and Lipid Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Colorectal and Anal Carcinomas
- Semiconductor Quantum Structures and Devices
Memorial Sloan Kettering Cancer Center
2021-2025
Chung-Ang University
2024
Weill Cornell Medicine
2021-2023
Cornell University
2021-2023
Icahn School of Medicine at Mount Sinai
2021
Michigan State University
2021
American Academy of Neurology
2021
University of Connecticut
2017-2019
Richard J. Daley College
2009
Argonne National Laboratory
2002-2009
Predicting whether a patient with cancer will benefit from immune checkpoint inhibitors (ICIs) without resorting to advanced genomic or immunologic assays is an important clinical need. To address this, we developed and evaluated SCORPIO, machine learning system that utilizes routine blood tests (complete count comprehensive metabolic profile) alongside characteristics 9,745 ICI-treated patients across 21 types. SCORPIO was trained on data 1,628 17 types Memorial Sloan Kettering Cancer...
Porous alumina membranes are commercially available and have been widely used in recent nanoscale research, for example, as templates nanowire fabrication through electrodeposition. In this report, we present a new use porous the of nanotubes/nanowires desired electrochemical devices catalytic applications. A high yield is obtained by etching an aqueous sodium hydroxide solution. We studied effects time solution concentration characterized using scanning electron microscope (SEM). discussion...
When the dimension of materials decreases to mesoscale, their properties can change dramatically, depending on boundary conditions imposed by sample architecture including geometry, morphology, and hierarchical structures. Here we show that electrodeposition, a method for reducing from solution onto substrate, provide versatile pathway tailor mesostructures. Novel lead (Pb) structures ranging nanowires, mesoparticles with octahedral, decahedral, icosahedral shapes porous multipods,...
Anodic aluminum oxide (AAO) membranes were characterized by UV Raman and FT-IR spectroscopies before after coating the entire surface (including interior pore walls) of AAO atomic layer deposition (ALD). reveals presence oxalate in bulk AAO, both ALD with Al2O3, because acid anion incorporation during anodization process used to produce membranes. The exhibits remarkable thermal stability, not totally decomposing air until exposed a temperature >900 degrees C. was cover either Al2O3 or TiO2....
Large area nickel antidot arrays with density up to 10^10 /cm^2 have been fabricated by depositing onto anodic aluminum oxide membranes that contain lattices of nanopores. Electron microscopy images show a high degree order the arrays. Various sizes and shapes antidots were observed increasing thickness deposited nickel. New features appear in both magnetization transport measurements when external magnetic field is parallel current direction, including an enhancement nonmonotonous...
Atomic layer deposition (ALD) is ideal for applying precise and conformal coatings over nanoporous materials. We have recently used ALD to coat two solids: anodic aluminum oxide (AAO) silica aerogels. AAO possesses hexagonally ordered pores with diameters d ~ 40 nm pore length L 70 microns. The membranes were coated by fabricate catalytic that demonstrate remarkable selectivity in the oxidative dehydrogenation of cyclohexane. Additional Pd films show promise as hydrogen sensors. Silica...
In this work, it has been shown that, through a highly controlled process, the chemical etching of anodic aluminum oxide membrane barrier layer can be performed in such way as to achieve nanometer-scale control pore opening. As is etched away, subtle differences revealed AFM phase imaging alumina composition give rise unique pattern hexagonal walls surrounding each domes. These nanostructures observed both topography and images understood oxalate anion contaminated versus pure alumina. This...
BACKGROUND. Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) is often an incurable disease, with patients experiencing median survival of under ten months significant morbidity. While immune checkpoint blockade (ICB) drugs are effective in ~20% patients, the remaining experience limited clinical benefit exposed to potential adverse effects financial costs. Clinically approved biomarkers, such as tumor mutational burden (TMB), have modest predictive value HNSCC.
This cohort study analyzed the safety and efficacy of immune checkpoint inhibitors in patients with cancer autoimmune disease, examined whether immune-related toxic effects were associated outcomes.
COVID-19 affects a wide spectrum of organ systems. We report 52-year-old man with hypertension and newly diagnosed diabetes mellitus who presented hypoxic respiratory failure due to developed severe brachial plexopathy. He was not treated prone positioning therapy. Associated the flaccid, painfully numb left upper extremity livedoid, purpuric rash on his hand forearm consistent COVID-19-induced microangiopathy. Neuroimaging electrophysiological data were near diffuse plexitis selective...
Targeted inhibition of BRAF V600E achieves tumor control in a subset advanced thyroid tumors. Nearly all tumors develop resistance, and some have been observed to subsequently undergo dedifferentiation. The molecular alterations associated with cancer dedifferentiation the setting are unknown. We analyzed targeted next-generation sequencing data from 639 advanced, recurrent and/or metastatic carcinomas, including 15 that were treated inhibitor drugs had tissue sampled during or...
We sought to explore current perspectives and attitudes of general neurologists movement disorder specialists toward deep brain stimulation (DBS) for Parkinson disease (PD), focusing on its earlier use in the clinical course disease.We designed a 30-question online survey comprised Likert-type, multiple choice, rank-order questions, which was distributed 932 neurologist members American Academy Neurology. analyzed clinicians' sociodemographic information, treatment patterns used patients...
We report a facile one‐step approach which involves no flammable gas, catalyst, and in situ polymerization for the preparation of well‐aligned carbon nanotube array. A polymer precursor is placed on top an anodized aluminum oxide (AAO) membrane containing regular nanopore arrays, slow heating under Ar flow allows molten to wet template through adhesive force. The spread into nanopores form nanotubes. Upon carbonization resulting multi‐walled nanotubes duplicate morphology precisely. process...
Consumption of cholesterol-rich foods, such as eggs, has a minimal effect on circulating cholesterol levels in healthy humans. To gain insight, we investigated whether phospholipids rich eggs (EPL) interfere with intestinal absorption vivo.To investigate the acute EPL absorption, male C57BL/6J mice were orally administered 6, 11, or 19 mg for three days. We also tested chronic consumption metabolism small intestine and liver diet-induced hypercholesterolemia. Male fed high fat/high (HF/HC;...
Densely covered (ET)X2 thin films (ET = bis-ethylenedithio-tetrathiafulvalene, X counter-anion) can be formed by selective electrodeposition on gold electrodes (see Figure). The insulating are converted to (ET)2X conductive through a novel conproportionation reaction. This procedure opens up the possibility prepare patterned and superconductive charge-transfer salt films.
We present the case of a patient with recent history ischemic stroke who presented clicking larynx syndrome, condition in which noises can be provoked by movement head and neck. Diagnostic imaging revealed unusual development posterior angulation superior horn thyroid cartilage that potentially was causing trauma to left common carotid artery. deduced symptomatic impingement artery not only cause patient's but also suspected her prior strokes due repetitive resulting thrombus. The managed...
Organic conductors and superconductors based on charge-transfer salts, such as (BEDT-TTF)2X [BEDT-TTF = bis(ethylenedithio)tetrathiafulvalene or ET], exhibit a wide variety of interesting phenomena that would be useful in numerous sensor electronic applications. Unfortunately, there has been difficulty creating thin, patterned films these materials, which required for any potential application. In an effort to resolve this problem, BEDT-TTF-like compound with dodecanethiol chain synthesized...