A5018076126- Zebrafish Biomedical Research Applications
- Natural Compound Pharmacology Studies
- Cell Adhesion Molecules Research
- Advanced Nanomaterials in Catalysis
- Nanoparticles: synthesis and applications
- Sesame and Sesamin Research
- Bone Tissue Engineering Materials
- Nitric Oxide and Endothelin Effects
- Angiogenesis and VEGF in Cancer
- Calcium Carbonate Crystallization and Inhibition
- Proteoglycans and glycosaminoglycans research
- Microplastics and Plastic Pollution
- Marriage and Family Dynamics
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- melanin and skin pigmentation
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Proteins in Food Systems
- Nanoparticle-Based Drug Delivery
- Recycling and Waste Management Techniques
- Dental Implant Techniques and Outcomes
- Environmental Chemistry and Analysis
- Demographic Trends and Gender Preferences
- Platelet Disorders and Treatments
National Nanotechnology Center
2015-2024
National Science and Technology Development Agency
2015-2024
Ramathibodi Hospital
2024
Mahidol University
2024
Fox Chase Cancer Center
2014
University of Pennsylvania
2011
Sidney Kimmel Cancer Center
2009
Thomas Jefferson University
2008-2009
Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2) constitutively activates mTORC1, increases cell proliferation, and induces pathological manifestations observed in (TS) pulmonary lymphangioleiomyomatosis (LAM). While role mTORC1 TSC2-dependent growth has been extensively characterized, little is known about mTORC2. Our data demonstrate that mTORC2 modulates TSC2-null proliferation survival through RhoA GTPase Bcl2 proteins. was inhibited not only by...
The high antibacterial and antiviral performance of synthesized copper(I) oxide (Cu2O) incorporated in zeolite nanoparticles (Cu-Z) was determined. Various Cu contents (1-9 wt %) solutions were loaded the matrix under neutral conditions at room temperature. All Cu-Z showed selectivity cuprous oxide, as confirmed by X-ray diffraction (XRD) photoelectron spectroscopy (XPS) analysis. An advantage prepared over pristine Cu2O its thermal stability. 7 9 % (07Cu-Z 09Cu-Z) exhibited best activities...
The treatment and regeneration of bone defects, especially tumor-induced is an issue in clinical practice remains a major challenge for substitute material invention.
Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, regulates collagen fibrillogenesis and cell growth. To further explore its biological function, we examined role Decorin during zebrafish development. Zebrafish is a chondroitin sulfate that exhibits high degree conservation with mammalian counterpart displays unique spatiotemporal expression pattern. Morpholino-mediated knockdown decorin identified developmental medial-lateral convergence anterior-posterior...
Synthesized hydroxyapatite (sHA)-calcium phosphate (CaP) based biomaterials play a vital role and have been widely used in the process of bone regeneration for defect repair, due to their similarities inorganic components human bones. However, tissue engineering purpose, composite components, physical biological properties, efficacy safety sHA still need further improvements. In this work, we synthesized inhomogeneous on biomimetic trace elements (Mg, Fe, Zn, Mn, Cu, Ni, Mo, Sr, Co, BO33-,...
α-Mangostin is the most active compound derived from pericarps of mangosteen. A number studies have reported its anticancer activity. However, only a few investigated toxicity this compound; moreover, teratogenicity α-mangostin has not been reported. In study, we evaluated effects on development zebrafish embryos. The exposure embryos to for 72 h dose-dependently induced mortality and abnormal development. LC 50 value at was 5.75 ± 0.26 μmol/L. We observed teratogenic in α-mangostin-treated...
Tetragonula laeviceps cerumen was sequentially extracted with 80% (v/v) methanol, dichloromethane, and hexane also in the reverse order. By MTT assay respective 50% inhibition concentration value, most active fraction further purified to apparent homogeneity by bioassay-guided silica gel column chromatography. α-Mangostin identified high-resolution electrospray ionization mass spectrometry nuclear magnetic resonance analyses. It had a potent cytotoxicity against BT474, Chago, Hep-G 2 ,...
Crinumasiaticum is a perennial herb widely distributed in many warmer regions, including Thailand, and well-known for its medicinal ornamental values. Crinum alkaloids contain numerous compounds, such as crinamine. Even though mechanism of action still unknown, crinamine was previously shown to possess anticancer activity. In this study, we demonstrate that more cytotoxic cervical cancer cells than normal cells. It also inhibited anchorage-independent tumor spheroid growth effectively...
Bioceramic materials have a wide range of applications in the biomedical field, such as repair bone defects and dental surgery. Silicate-based bioceramics attracted researchers' interest due to their bioactivity biodegradability. In this study, extended scope ZAS utilization tissue engineering by introducing calcium-magnesium-silicate (diopside, CMS) an interface material aim develop machinable bioceramic composite (ZASCMS) sol-gel method. The physicochemical characterization, vitro...
Investigating fine particulate matter (PM2.5) toxicity is crucial for health risk assessment and pollution control. This study explores the developmental of two PM2.5 sources: standard reference material 2786 (NIST, USA) from Chakri Naruebodindra Medical Institute (CNMI, Thailand) located in Bangkok Metropolitan area. Zebrafish embryos exposed to these samples exhibited embryonic mortality, with 50% lethal concentration (LC50) values 1476 µg/mL 512 CNMI PM2.5. Morphological analysis revealed...
The molecular program controlling hematopoietic differentiation is not fully understood. Here, we describe a family of zebrafish genes that includes novel regulator, draculin-like 3 (drl.3). We found drl.3 expressed in mesoderm-derived cells and retained during erythroid maturation. Moreover, expression correlated with development gata1a- spi1b-depleted embryos. Loss-of-function analysis indicated plays an essential role primitive erythropoiesis and, to lesser extent, myelopoiesis...
Polyhexamethylene guanidine-phosphate (PHMG-P), a guanidine-based cationic antimicrobial polymer, is an effective biocide, potent even at low concentrations. Due to its resilient bactericidal properties, it has been used extensively in consumer products. It was safely until use humidifiers led catastrophic event South Korea. Epidemiological studies have linked the of PHMG-P as humidifier disinfectant pulmonary fibrosis. However, little known about harmful impacts other than Thus, we applied...
α-Mangostin is a primary active compound found in mangosteen pericarp that has been used as traditional medicine Thailand and other countries Southeast Asia. Since toxicological information limited, developmental toxicity transcriptional effects of α-mangostin during embryogenesis zebrafish were studied. Zebrafish embryos exposed to (up 15 µmol/L) from 4 hours up 72 the 50% lethal concentration was estimated 6.9 ± 1.9 µmol/L. The induced defects embryos/larvae, mainly consisting truncated...
Multifunctional nanoparticles with special magnetic and optical properties have been attracting a great deal of attention due to their important applications in the bioanalytical biomedical fields. In this study, we report fabrication biocompatible magneto-fluorescence consisting carbon dots (CDots) silica-coated cobalt-manganese nanoferrites (Co0.5Mn0.5Fe2O4) (CoMnF@Si@CDots) (MagSiCDots) by facile hydrothermal method. The as-prepared MagSiCDots particle size 100-120 nm show negative zeta...