A5066287691- Frailty in Older Adults
- Nutrition and Health in Aging
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- COVID-19 and healthcare impacts
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Healthcare Technology and Patient Monitoring
Sheba Medical Center
2020-2024
Tel Aviv University
2016-2024
Rabin Medical Center
2023-2024
Alzheimer's Association of Israel
2020
Myelodysplastic Syndrome (MDS) is a common blood dyscrasia that mainly affects the elderly population. Several prognostic scores are available utilizing count variables and cytogenetic abnormalities, targeting disease rather than patient. Sarcopenia frailty associated with shortened survival rates in various states. Low Alanine Aminotransferase (ALT) levels marker of lowered muscle mass status. This study aimed to examine correlation between low ALT prognosis MDS patients. retrospective...
Background Under- or late identification of pulmonary embolism (PE)—a thrombosis 1 more arteries that seriously threatens patients’ lives—is a major challenge confronting modern medicine. Objective We aimed to establish accurate and informative machine learning (ML) models identify patients at high risk for PE as they are admitted the hospital, before their initial clinical checkup, by using only information in medical records. Methods collected demographics, comorbidities, medications data...
Patients admitted to general wards are inherently at risk of deterioration. Thus, tools that can provide early detection deterioration may be lifesaving. Frequent remote patient monitoring (RPM) has the potential allow such detection, leading a timely intervention by health care providers.This study aimed assess novel wearable RPM device alerts in patients high for deterioration.This prospective observational was conducted two large tertiary medical center. determined deteriorate upon...
The COVID-19 pandemic accelerated the assimilation of telemedicine platforms into medical practice. Nevertheless, research-based evidence in this field is still accumulating. This was a prospective, cross-sectional comparative assessment remote physical examination device used mainly for heart and lung digital auscultation. We analyzed usage patterns, user (physician) subjective appreciation compared it to legacy measures. Eighteen physicians (median age 36 years (IQR 32-45): two interns,...
Sarcopenia and frailty are causes for morbidity mortality amongst heart failure (HF) patients. Low alanine transaminase (ALT) is a marker these syndromes and, therefore, could serve as biomarker the prognostication of HF We performed retrospective analysis all consecutive hospitalized patients in our institute order to find out whether low ALT values would be poor outcomes. Our cohort included 11,102 patients, 35.6% categorized with reduced ejection fraction. excluded > 40 IU/L cirrhosis....
Sarcopenia is characterized by loss of muscle mass and function associated with frailty, a syndrome higher likelihood falls, fractures, physical disability, mortality. Both frailty sarcopenia are known markers shorter survival in various cancer patient populations. Low alanine aminotransferase (ALT), reflecting (sarcopenia), may be greater multiple cancers. To assess the potential association between low ALT among prostate (PCa) patients survivors. This was retrospective analysis historical...
Background In-hospital stay of acutely ill elderlies could be reduced by increasing the availability community-based hospitalizations. The feasibility remotely managing these patients specialized internists, without leaving their nursing homes should sought. In current pivotal study, we aimed to evaluate aforementioned model. Methods This was a prospective, open-label study at tertiary medical center and home. comparing clinical outcomes hospitalized in each location. Results Over period 5.5...
Abstract Aims To describe the phenotype, genetics, and events associated with development of hypertrophic cardiomyopathy (HCM) reduced ventricular function (HCMr). Heart failure in HCM is usually preserved ejection fraction, yet some patients develop impaired systolic that worse outcomes. Methods results Our registry included 1328 from two centres Spain Israel. Patients normal baseline were matched, a competing‐risk analysis was performed to find factors HCMr development. Patient records...
Abstract Recurrent pericarditis (RP) complicates approximately 30% of acute (AP) cases. We sought to compare the prevalence and severity objective findings seen in patients with RP. A retrospective single-center study during 2010–2019, including 765 diagnosed AP. Clinical, electrocardiographic, echocardiographic, laboratory were extracted from local electronic health records. Recurrence follow-up was documented 134 (17.5%), a median time recurrence 101 (± 59–251) days. The age 60 years (IQR...
Background Patients suffering from sepsis experience organ failure and metabolic derangements, with a negative impact on their prognosis survival. Objective markers for dismal in this group of patients are sought. Aims To assess the potential role corrected QT interval anomalies as surrogates derangements leading to increased short medium‐term mortality sepsis. Methods This study utilised historic‐cohort analysis 257 septic admitted internal medicine departments. Personal data, vital signs,...
Background: Sarcopenia and Frailty are syndromes that affect the clinical outcomes of patients suffering from a wide range diseases. The use Computed Tomography (CT) is well established for evaluation via estimation Skeletal Muscle Index (SMI) at level third lumbar vertebra (L3SMI). Nevertheless, association more readily available biomarkers desired. Recent studies have associated low Alanine amino-transferase ALT (SGPT) levels with frailty. current study aimed to establish between L3SMI...
Sarcopenia and frailty influence clinical patients' outcomes. Low alanine aminotransferase (ALT) serum activity is a surrogate marker for sarcopenia frailty. In-hospital hypoglycemia associated, also with worse outcomes.We evaluated the association between low ALT, risk of in-hospital subsequent mortality.This was retrospective cohort analysis.We included patients hospitalized in tertiary hospital 2007 2019. Patients' data were retrieved from their electronic medical records.The 51 831...
Background The association of pulmonary and systemic arterial hypertension is believed to be mediated through hypertensive left heart disease. purpose the current study was investigate whether (PHT) associated with among patients apparently normal ventricular diastolic function. Methods Results Consecutive who had echocardiographic evaluation between 2007 2019 were enrolled. Patients disease states that are known PHT, including dysfunction, excluded from analysis. Estimated right systolic...
Sarcopenia is characterized by the loss of muscle mass and function associated with frailty, a syndrome linked to an increased likelihood falls, fractures, physical disability. Both frailty sarcopenia are recognized as markers for shortened survival in number medical conditions cancer patient populations. Low alanine aminotransferase (ALT) values, representing low (sarcopenia), may be subsequently patients. In current study, we aimed assess potential relationship between ALT shorter bladder...
Abstract Objective Investigate the safety and efficacy of preoperative levosimendan in patients undergoing left ventricular assist device (LVAD) implantation. Methods Consecutive who received LVADs (HeartMate-2, 3, HVAD) a single tertiary medical center (2012–2018). INTERMACS profile 1 were excluded. The primary outcome was post-LVAD right failure (RVF) inhospital mortality rates. secondary outcomes included other clinical, echocardiographic hemodynamic parameters at follow-up. Results Final...
In humans, bradykinin contributes to the acute renin response after ACE inhibition. To further explore role of endogenous in human regulation, we determined effect HOE 140, a specific B<sub>2</sub> receptor antagonist, on 0.5 mg/kg i.v. furosemide randomized, single blind, crossover design study 10 healthy, salt-replete volunteers. 140 did not affect basal plasma activity, aldosterone, mean arterial pressure, or heart rate. Furosemide administration increased activity from 1.0 ± 0.2 4.5 1.2...
Our study was aimed at developing and validating a new approach, embodied in machine learning-based model, for sequentially monitoring hospitalized COVID-19 patients directing professional attention to whose deterioration is imminent. Model development employed real-world patient data (598 prediction events 210 patients), internal validation (315 97 external (1373 307 patients). Results show significant divergence longitudinal values of eight routinely collected blood parameters appearing...