A5103055399- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Vascular Anomalies and Treatments
- Occupational exposure and asthma
- Pleural and Pulmonary Diseases
- Systemic Sclerosis and Related Diseases
- Non-Invasive Vital Sign Monitoring
- Inhalation and Respiratory Drug Delivery
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Congenital Heart Disease Studies
- IgG4-Related and Inflammatory Diseases
- Cardiovascular Issues in Pregnancy
- CAR-T cell therapy research
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Diagnosis and Treatment of Venous Diseases
- Emergency and Acute Care Studies
Sheba Medical Center
2016-2025
Tel Aviv University
2014-2024
Indiana University School of Medicine
2009
Indiana University
2009
Hadassah Medical Center
2002-2005
Tufts Medical Center
2005
Hadassah Academic College
1998
Summary. Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time‐course bleomycin‐induced fibrosis in mice using computer‐assisted morphometry. C57Bl/6J were treated with single IT dose or control saline. Animals killed 3, 6, 14 and 21 days post‐IT. Lung injury was evaluated by analysis bronchoalveolar lavage (BAL) fluid, hydroxyproline concentration lung, routine light microscopic examination resulting...
Pulmonary function tests (PFT) are recommended for hematopoietic cell transplantation (HCT) evaluation. However, their prognostic value in chimeric antigen receptor T-cell (CAR-T) therapy remains unclear. We assessed the predictive significance of PFTs and pulmonary comorbidity classifications, per Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI), B-cell lymphoma patients undergoing autologous CD19-CAR-T therapy. Single-center retrospective analysis encompassing 192 with...
<b><i>Background:</i></b> Lung injury with development of the acute respiratory distress syndrome (ARDS) is a serious complication which can occur after major surgery, including cardiac surgery. <b><i>Objective:</i></b> The aim our study was to compare prevalence, risk factors, and mortality ARDS following surgery according American-European Consensus Conference (AECC) definition new Berlin ARDS. <b><i>Methods:</i></b>...
IFN-γ production is upregulated in lung cells (LC) of bleomycin-treated C57BL/6 mice. The present study characterizes the time course, cellular source, and regulation expression bleomycin-induced injury. mRNA LC from mice peaked 3 days after intratracheal instillation. protein levels were increased at 6 days, as was percentage expressing IFN-γ. CD4 + , CD8 natural killer each contributed significantly to production. IL-12 1 day Anti-IL-12 anti-IL-18 antibodies decreased by these cells. To...
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Acute exacerbations COPD (AECOPD) drastically affect the clinical course disease. We aimed to evaluate treatment AECOPD in internal medicine departments Israel, nationwide.The Israeli survey (COPDIS) first national patients admitted with between 2017 2019. The includes prospective (n = 344) retrospective 1,166) data from 13 medical centers. analyzed pre-hospital, in-hospital, pre-discharge care....
Infusions of aminobisphonates (ABP) activate Vγ9δ2T cells in vivo and induce an acute inflammatory response 30% patients treated for osteoporosis. Following the observation digital thrombosis a systemic sclerosis (SSc) patient after treatment with intravenous ABP, zoledronate (Zol), we evaluated whether control peripheral blood (PB) mononuclear cell (MC, PBMC) acquire prothrombotic phenotype to Zol.Vγ9δ2T both healthy donors (HD) upregulated CD69 activation antigen secreted tumor necrosis...
The role of IL-4 in the development lung fibrosis is as yet unclear. Bleomycin (Bleo) or saline (Sal) was injected intratracheally into three groups C57BL/6J mice: transgenic animals that overexpressed (IL-4 TG, n = 14), mice with a targeted knockout mutation gene KO, 11), and wild-type (WT, 13) mice. At 14 days, evaluated by hydroxyproline measurement quantitative image analysis fraction alveolar wall area fraction. Bronchoalveolar lavage cell counts all Bleo-treated demonstrated an...
Evaluation of unexplained exercise intolerance is best resolved by cardiopulmonary testing (CPET) which enables the determination limiting system in most cases. Traditionally, pulmonary function tests (PFTs) at rest are not used for prediction a respiratory limitation on CPET. We sought cut-off values PFTs that might, priori, rule-in or rule-out Patients who underwent CPET our institute were divided into two groups according to spirometry: obstructive and non-obstructive. Each group was...
Summary The role of lymphocytes in the pathogenesis lung fibrosis is not clear, but weight evidence supports a pro‐fibrotic effect for lymphocytes. high‐affinity interleukin‐2 receptor (haIL‐2R) expressed on activated, quiescent, T This selective expression haIL‐2R provides basis therapeutic strategies that target IL‐2R‐expressing cells. We hypothesized elimination activated by IL‐2R‐targeted chimeric proteins might ameliorate fibrosis. investigated effects IL‐2‐Bax, novel apoptosis‐inducing...
Readmission after hospitalization for acute COPD exacerbation (AE-COPD) has been proposed as a healthcare quality indicator (QI) in Israel. We studied patients hospitalized AE-COPD, towards determining whether AE-COPD readmission is an appropriate national QI order to improve patient care.
Background The association of pulmonary and systemic arterial hypertension is believed to be mediated through hypertensive left heart disease. purpose the current study was investigate whether (PHT) associated with among patients apparently normal ventricular diastolic function. Methods Results Consecutive who had echocardiographic evaluation between 2007 2019 were enrolled. Patients disease states that are known PHT, including dysfunction, excluded from analysis. Estimated right systolic...
Expiratory flow limitation at resting tidal volume (EFLTV) presents a severe mechanical constraint in chronic lung diseases and has not yet been studied longitudinally cystic fibrosis.To study the effect of EFLTV as it emerged from simple spirometry on function clinical status fibrosis.Best year that included flow/volume curves related data were retrospectively collected over 12 ± 3.0 yr/person 108 subjects with fibrosis. The which forced expiratory flow, midexpiratory phase (FEF25-75%, L/s)...
Background: There is no agreement on the best strategy for interpreting/ analyzing cardiopulmonary exercise test (CPET) results. Aims: This study aims to evaluate feasibility of using computer-aided algorithms CPET data identify limitation/ intolerance level. Methods: used 206 retrospective files from Pulmonary Institute and Cardiology Rehabilitation Center at Sheba Medical 50 physiology laboratory Washington-Hill College, both in Israel. Eighty patients with confirmed primary...