A5088772169- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Sirtuins and Resveratrol in Medicine
- Bee Products Chemical Analysis
- Insect Pest Control Strategies
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Phytochemistry and Biological Activities
- RNA Research and Splicing
- Protein Interaction Studies and Fluorescence Analysis
- Sulfur Compounds in Biology
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Alzheimer's disease research and treatments
- Insect Utilization and Effects
- Glutathione Transferases and Polymorphisms
- Cholesterol and Lipid Metabolism
- Vitamin C and Antioxidants Research
Sichuan University
2017-2024
Chengdu University
2024
Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of pigment epithelium (RPE) cells. However, mechanism RPE cell induced SI remains unclear. In this study, we investigated necrotic features cultured human (ARPE-19) cells treated with and found that apoptosis or necroptosis was not major pathway. Instead, process accompanied significant elevation intracellular labile iron level, ROS, lipid peroxides which recapitulated key...
The death of dopaminergic neurons is a dominant factor during the occurrence and development Parkinson's disease (PD). Previous studies demonstrated that ferroptosis implicated in neurons. Besides, polyphenols have been proven to be effective preventing This work aims explore neuroprotective effect mechanism thonningianin A (Th A), polyphenolic compound natural plant foods, against 6-hydroxydopamine (6-OHDA)-induced cells. results molecular docking other binding assays collectively Th can...
Ferroptosis is crucial to the pathology of many neurological diseases. Here, we found pre-treatment with myriocin, an inhibitor de novo synthesis sphingolipid, significantly decreased erastin- or glutamate-induced ferroptosis HT22 cells without requiring recovery intracellular glutathione. The transcriptome analysis treated myriocin identified hypoxia-inducible factor 1 (HIF-1) pathway as a prime and novel drug target. Further study validated that HIF1α was required for cytoprotective...
Advanced glycation end products (AGEs) are the compounds produced by non-enzymatic of proteins, which involved in diabetic-related complications. To investigate potential anti-glycation activity Myriocin (Myr), a fungal metabolite Cordyceps, effect Myr on formation AGEs resulted from bovine serum albumin (BSA) and interaction between BSA were studied multiple spectroscopic techniques computational simulations. We found that inhibited at stage reaction exhibited strong anti-fibrillation...
Idesia polycarpa Maxim. var. vestita Diels (I. polycarpa) is well known as an edible oil plant which contains abundant linoleic acid and polyphenols. The objective of this study was to maximize the by-product defatted fruit I. polycarpa. We found that fraction D ethyl acetate extract (EF-D) contained more polyphenols, contribute its strong antioxidant activity by assays (DPPH, ABTS, FRAP). Meanwhile, EF-D showed a significant lipid-lowering effect on oleic acid- (OA-) induced hepatic...
Excessive amounts of reactive oxygen species (ROS) in the body are a key factor development hepatopathies such as hepatitis. The aim this study was to assess antioxidation effect vitro and hepatoprotective activity active fragment Veronica ciliata Fisch. (VCAF). Antioxidant assays (DPPH, superoxide, hydroxyl radicals scavenging) were conducted, effects through application tert ‐butyl hydroperoxide‐ (t‐BHP‐) induced oxidative stress injury HepG2 cells evaluated. VCAF had high phenolic...
Neem leaves have long been used in traditional medicine for promoting longevity. However, the precise mechanisms underlying their anti-aging effects remain elusive. In this study, we investigated impact of neem leaf extract (NLE) extracted from a 50% ethanol solution on chronological lifespan Saccharomyces cerevisiae, revealing an extension lifespan, heightened oxidative stress resistance, and reduction reactive oxygen species. To discern active compounds NLE, LC/MS GNPS platform were...